Table 1 Optimization chart of the allopurinol loaded nano lipid carrier (ALP-loaded NLCs)
| Â | Factor 1 | Factor 2 | Factor 3 | Response 1 | Response 2 | Response 3 | |
|---|---|---|---|---|---|---|---|
Standard deviation | Run | Stearic acid (mg) | Allopurinol (mg) | Tween-20 (mg) | PS (nm) | ZP (mV) | EE (%) |
11 | 1 | 8 | 1 | 1.5 | 260.01 ± 2.3 | -23.6 ± 0.8 | 74.1 ± 1.3 |
1 | 2 | 7 | 1 | 1 | 238.13 ± 3.1 | -31.5 ± 1.10 | 87.3 ± 1.1 |
3 | 3 | 7 | 2 | 1 | 262.07 ± 4.3 | -39.5 ± 1.14 | 75.1 ± 1.6 |
10 | 4 | 8 | 2 | 0.5 | 289.1 ± 2.9 | -33.1 ± 0.87 | 61.2 ± 1.7 |
4 | 5 | 9 | 2 | 1 | 330.8 ± 3.6 | -36.00 ± 1.4 | 55.7 ± 2.1 |
13 | 6 | 8 | 1.5 | 1 | 275.04 ± 3.2 | -36.4 ± 0.93 | 68.1 ± 1.5 |
5 | 7 | 7 | 1.5 | 0.5 | 270.09 ± 3.3 | -33.7 ± 1.21 | 70.3 ± 1.8 |
6 | 8 | 9 | 1.5 | 0.5 | 323.3 ± 4.3 | -33.9 ± 1.10 | 50.5 ± 1.8 |
7 | 9 | 7 | 1.5 | 1.5 | 255.12 ± 1.9 | -35.5 ± 0.96 | 78.3 ± 2.5 |
9 | 10 | 8 | 1 | 0.5 | 270.07 ± 3.7 | -36.1 ± 1.30 | 66.1 ± 1.6 |
8 | 11 | 9 | 1.5 | 1.5 | 305.01 ± 4.3 | -36.5 ± 1.23 | 57.0 ± 1.1 |
12 | 12 | 8 | 2 | 1.5 | 268.3 ± 3.9 | -43.9 ± 0.76 | 64.0 ± 2.0 |
14 | 13 | 8 | 1.5 | 1 | 273.45 ± 4.1 | -35.9 ± 1.42 | 67.5 ± 1.31 |
2 | 14 | 9 | 1 | 1 | 292.32 ± 3.8 | -30.6 ± 0.31 | 63.6 ± 0.9 |