Fig. 7
From: GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity
cGAS-STING activation is involved in DOX-induced cell death in cultured cardiomyocytes (A-D). A siRNA-mediated STING knockdown influenced the protein levels of C-Caspase3, Caspase3, BAX and BCL-2 in indicated groups in HL-1 cells (n = 6). B-C Flow cytometry assay and TUNEL staining showed that STING knockdown reduced cell apoptosis (n = 4). D CCK8 assay detection reveals that STING knockdown increased cell viability. E STING knockdown suppressed the protein levels of NLPR3