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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells

Fig. 1

IL-1β inhibited ECM synthesis and was restored by CXB in a dose and time-dependent manner in NPCs. A Chemical formula and structure of CXB provided by the manufacturer. B Cytotoxicity assay of IL-1β and CXB. C, D Expression of aggrecan, type I and II collagen decreased as the concentration of IL-1β increased. E, F Treating with CXB for 24 h restored ECM synthesis in a dose-dependent manner. G, H NPCs pre-treated with 10 µM CXB for 24, 48, 72 h, and treated with IL-1β for 24 h enhanced ECM synthesis in a time-dependent manner. The grouping of blots were cropped from different parts of different blots. Data are represented as mean with SD of more than three repeats, performed in triplicates. *P ≤ 0.05, **P ≤ 0.01, *** P ≤ 0.001

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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