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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing

Fig. 3

Effect of Radotinib (Rb) on lung fibrosis in bleomycin-induced Rat model. The rats were divided three groups; untreated group (UN): administered with water; Bleomyin induced group (Bl): treated with Bleomycin (5 mg/kg); bleomycin and Rb group (Bl + Rb): rats were treated with 5 mg/kg of Bleomycin and administered with Rb (30 mg/kg) daily for 21 days. Rats were sacrificed, and lung tissues were isolated. A Lung tissues were stained with hematoxylin and eosin. B Lung tissues were stained with Masson’s trichrome (M/T). The black arrows indicate the collagen accumulation. C and E The tissues were stained with specific antibodies such as anti-collagen type I (Col I) and fibronectin. Brown color indicates a positive signal. D and F The bar graphs show the brown intensity of the left photographs, respectively. The intensity of UN is expressed as 100%. Data are expressed as means ± standard deviations (n = 4). * p < 0.05 vs. UN ; # p < 0.05 vs. Bl

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