From: Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells
Treatments | Concentrations | ET (h) | Chromosomal alterations (CA) | Total CA | ||||
---|---|---|---|---|---|---|---|---|
Micronuclei | c-metaphases | Bridges | Losses | Delays | ||||
NC | - | 24 | 0.2 ± 0.5 | 0.2 ± 0.5 | 0.25 ± 0.5 | 0.0 ± 0.0 | 0.75 ± 0.5 | 1.40 ± 0.5 |
PC (ug/mL) | 0.006 mg/ml | 3.8 ± 0.9a | 4.5 ± 0.5a | 10.2 ± 0.9a | 5.25 ± 2.62a | 10.5 ± 1.29a | 34.25 ± 4.7a | |
TRZ (µg/mL) | 400 µg/mL | 3.0 ± 0.9a | 6 ± 4.1a | 1.5 ± 1.2b | 0.75 ± 0.5b | 2.5 ±1.29b | 15.04 ± 4.2ab | |
200 µg/mL | 2.3 ± 0.9 | 6 ± 4.1a | 1.0 ± 2.0b | 7.0 ± 7.52a | 0.5 ± 1.0b | 16.75 ± 4.3ab | ||
100 µg/mL | 2.2 ± 2.0 | 4.5 ± 1.7a | 1.0 ± 1.41b | 0.75 ± 0.95b | 0.75 ± 0.95b | 9.2 ± 3.5ab | ||
NC | - | 72 | 0.2 ± 0.5 | 0.15 ± 0.5 | 0.0 ± 0.0 | 0.2 ± 0.5 | 0.4 ± 0.3 | 0.9 ± 0.3 |
PC (µg/mL ) | 0.006 mg/ml | 4.2 ± 0.7a | 4.9 ± 0.4a | 12.3 ± 1.2a | 7.2 ± 1.9a | 11.4 ± 0.9a | 40.05 ± 4.9a | |
TRZ (µg/mL) | 400 µg/mL | 4.0 ± 3.1a | 2.5 ± 1.2 | 2 ± 1.4b | 0.25 ± 0.5b | 2.0 ± 2.4b | 10.75 ± 2.5ab | |
200 µg/mL | 2.7 ± 1.2 | 4.25 ± 3.0a | 0.5 ± 0.5b | 0.75 ± 0.5b | 0.7 ± 1.5b | 9.0 ± 2.2ab | ||
100 µg/mL | 2.0 ± 1.41 | 3.5 ± 1.9a | 1.0 ± 1.1b | 1.0 ± 2.0b | 1.2 ± 1.8b | 8.75 ± 1.2ab |