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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil

Fig. 3

Curve shift of Propofol with midazolam or alfentanil. Panel A Sedation without alfentanil. The dashed lines represent 95%,50% and 5% chance of LOR. The propofol concentration, when given alone, to achieve 95% chance of LOR is 1.59 μg/mL. This requirement is lowered to 0.7 and 0.32 μg/mL if coupled with midazolam 1 mg and 2 mg respectively (dotted lines). Panel B Sedation without midazolam. Propofol concentration is 1.59, 1.37 and 1.12 μg/mL when given alone, with 500 μg and 250 μg alfentanil

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