Fig. 4

Photomicrographs of cortical brain sections for CB1 receptor immune expression in WIN55, 212–2 treated mice and controls. Images a, c & e represent female mice sections and b, d &f images represent male sections. Image a control and vehicle females and b: control and vehicle males. Controls showed more expression of CB1 receptors in female mice. Positive neurons are marked with arrows. Images c & d showed the low dose groups with higher immune expression compared to the control and vehicle groups which are more marked in female mice. Images e & f: high dose groups showed more CB1 expression than the low dose groups (scale bar = 100um)