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Table 3 Biochemical assessment of liver and kidney functions in WIN55, 212–2 treated mice versus controls

From: Behavioral, biochemical and histopathological toxic profiles induced by sub-chronic cannabimimetic WIN55, 212–2 administration in mice

Test

Control

Vehicle

WIN55, 212–2

0.05 mg/kg

WIN55, 212–2

0.1 mg/kg

P-value

ALT

17.1 ± 1.92

17.9 ± 1.93

18.8 ± 2.56

19.8 ± 2.56

NS

AST

52.8 ± 2.43

56.8 ± 2.06

57.4 ± 2.31

59.2 ± 0.82

NS

Blood urea

40.60 ± 15.23

44.6 ± 18.45

45.10 ± 14.82

47.60 ± 10.73

NS

Serum creatinine

0.13 ± 0.03

0.14 ± 0.06

0.16 ± 0.04

0.18 ± 0.05

NS

  1. One-way ANOVA test, data are expressed as mean ± SD
  2. NS: non-significant