Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice

Table 3 Plasma tramadol concentration after different treatments

Treatment	20 mg/kg	40 mg/kg	80 mg/kg	160 mg/kg	320 mg/kg	Tramadol	Diazepam
CS	2868.65 ± 63.25^@	2789.27 ± 58.91^@	1342.22 ± 10.64^ab*^@	692.98 ± 10.78^abc*	836.04 ± 26.81^abc*@	2679.85 ± 30.84	2166.23 ± 58.12
CSFe3	2747.85 ± 32.32	2076.59 ± 27.78	2361.67 ± 675.34	1265.63 ± 187.54^*@	2084.42 ± 402.79	2679.85 ± 30.84	2166.23 ± 58.12
CSZn3	899.61 ± 6.89*^@	881 ± 1.34*^@	694.83 ± 22.27^ab*^@	564.78 ± 23.88^ab*^@	1088.26 ± 79.6^abcd*^@	2679.85 ± 30.84	2166.23 ± 58.12

Plasma samples were extracted 1 h after tramadol administration and stored at -20℃ till analysis. Data represents average of 4 mice ± SEM. Significance at p < 0.05 using one-way ANOVA followed by Tukey's multiple range test. a For comparison against 20 mg/kg, b For comparison against 40 mg/kg, c For comparison against 80 mg/kg, d For comparison against 160 mg/kg, * For comparison against tramadol, @ For comparison against diazepam
CS wollastonite-treated mice, CSFe3 wollastonite doped with 3% iron oxide, CSZn3 wollastonite doped with 30% zinc oxide

ISSN: 2050-6511