Skip to main content
Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Vanillic acid alleviates methamphetamine-induced mitochondrial toxicity in cardiac mitochondria via antioxidant activity and inhibition of MPT Pore opening: an in-vitro study

Fig. 3

Ameliorative effect of VA on methamphetamine -induced mitochondrial release of ROS. Cardiac mitochondria were treated/cotreated with methamphetamine, methamphetamine plus various concentrations (10, 50 and 100 µM) of VA and VA (100 µM) alone for 60 min. mitochondrial ROS was measured using flow cytometric analysis. Methamphetamine increased mitochondrial ROS in cardiac mitochondria. Treatment with VA (100 µM) significantly ameliorated methamphetamine-induced mitochondrial ROS. Data are presented as the mean ± SD. *** p < 0.001 versus untreated control; ## p < 0.01 versus methamphetamine group (one-way ANOVA followed by Tukey’s multiple comparison tests). ROS, reactive oxygen species; METH, methamphetamine; VA, Vanillic acid; SD standard deviation; DCF, Dichlorofluorescein

Back to article page

BMC Pharmacology and Toxicology

ISSN: 2050-6511

Contact us