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Basic pharmacology

Section edited by David Farb

This section considers submissions that focus on receptor pharmacology, signal transduction, pharmacokinetics and pharmacogenomics relating to all organ systems.

Page 1 of 2

  1. Content type: Research article

    KCNH family of potassium channels is responsible for diverse physiological functions ranging from the regulation of neuronal excitability and cardiac contraction to the regulation of cancer progression. KCNH c...

    Authors: Ze-Jun Wang, Purushottam B. Tiwari, Aykut Üren and Tinatin I. Brelidze

    Citation: BMC Pharmacology and Toxicology 2019 20:42

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  2. Content type: Research article

    Chronic kidney disease (CKD) is a significant health burden that increases the risk of adverse events. Currently, there is no validated models to predict risk of mortality among CKD patients experienced advers...

    Authors: Monica Danial, Mohamed Azmi Hassali, Ong Loke Meng, Yoon Chee Kin and Amer Hayat Khan

    Citation: BMC Pharmacology and Toxicology 2019 20:41

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  3. Content type: Research article

    Antibiotic-resistant pathogens are an emerging threat in this century. Epinecidin-1 is a multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides) has been shown to ha...

    Authors: Alireza Neshani, Hosna Zare, Mohammad Reza Akbari Eidgahi, Azad Khaledi and Kiarash Ghazvini

    Citation: BMC Pharmacology and Toxicology 2019 20:33

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  4. Content type: Research article

    It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell functi...

    Authors: Jingwei Zhang, Guanghui Hu, Bisheng Huang, Dong Zhuo, Yujie Xu, Huitao Li, Xiangcheng Zhan, Ren-Shan Ge and Yunfei Xu

    Citation: BMC Pharmacology and Toxicology 2019 20:32

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  5. Content type: Research article

    The activation of neurohumoral compensatory mechanisms is a common physiological phenomenon in heart failure in order to make up for a failing heart, which will usually have a deteriorating effect on overall h...

    Authors: Kawa Dizaye and Rojgar H. Ali

    Citation: BMC Pharmacology and Toxicology 2019 20:23

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  6. Content type: Research article

    The development of heart failure is accompanied by complex changes in cardiac electrophysiology and functional properties of cardiomyocytes and fibroblasts. Histone deacetylase (HDAC) inhibitors hold great pro...

    Authors: Johanna K. Freundt, Gerrit Frommeyer, Tilmann Spieker, Fabian Wötzel, Jochen Schulze Grotthoff, Jörg Stypmann, Georg Hempel, Michael Schäfers, Andreas H. Jacobs, Lars Eckardt and Philipp S. Lange

    Citation: BMC Pharmacology and Toxicology 2019 20:16

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  7. Content type: Research article

    Basic function of bromine in body is to activate pepsin production in gastritis with low acidity. The present study encompasses a broad in vivo study to evaluate gastroprotective activity of a novel dibromo su...

    Authors: Kamelia Saremi, Sima Kianpour Rad, Faezeh Tayeby, Mahmood A. Abdulla, Hamed Karimian and Nazia Abdul Majid

    Citation: BMC Pharmacology and Toxicology 2019 20:13

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  9. Content type: Research article

    There is evidence that atypical antipsychotics (APs) increase risk of osteoporosis in schizophrenia patients, however the mechanism is unclear. The aim of the study was to explore the molecular mechanisms abou...

    Authors: Peifan Li, Yiming Wang, Xingde Liu, Zhen Zhou, Jun Wang, Haiyan Zhou, Lei Zheng and Lixia Yang

    Citation: BMC Pharmacology and Toxicology 2019 20:10

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  11. Content type: Research article

    Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. Consequently,...

    Authors: Hari Krishna Ananthula, Scott Parker, Erin Touchette, R. Mark Buller, Gopi Patel, Daniel Kalman, Johanna S. Salzer, Nadia Gallardo-Romero, Victoria Olson, Inger K. Damon, Tessa Moir-Savitz, Larry Sallans, Milton H. Werner, Catherine M. Sherwin and Pankaj B. Desai

    Citation: BMC Pharmacology and Toxicology 2018 19:80

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  13. Content type: Research article

    Ethnicity variation is one of the main factors that may affect drug response in clinical practice. As MTHFR gene affects different transcriptome and proteome which affect the clinical response of drugs. Purpos...

    Authors: Shakir Ullah, Niaz Ali, Adnan Khan, Saad Ali, Haleema Rehna Nazish and Zia Uddin

    Citation: BMC Pharmacology and Toxicology 2018 19:73

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  14. Content type: Research article

    3,3′-Diindolylmethane (DIM) has been extensively studied as a potential therapeutic drug with free radical scavenging, antioxidant and anti-angiogenic effects. However, whether DIM has similar effects on cardi...

    Authors: Qiang Luo, Ankang Yang, Quan Cao and Hongjing Guan

    Citation: BMC Pharmacology and Toxicology 2018 19:71

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  15. Content type: Research article

    An increasing number of studies are investigating the effects of Chinese medicine on hepatic fibrosis, but only few studies have examined the anti-fibrogenic properties of Artesunate (ART). The aim of the pres...

    Authors: Jian Lv, Ruidan Bai, Li Wang, Jiefang Gao and Hong Zhang

    Citation: BMC Pharmacology and Toxicology 2018 19:64

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  17. Content type: Research article

    The aim of the present in vitro study was to investigate, in different genders, motor responses in surgical colonic specimens from patients with rectal cancer undergoing and not undergoing chemotherapy with ca...

    Authors: Maria Antonietta Maselli, Antonia Ignazzi, Francesco Pezzolla, Annunziata Scirocco, Dionigi Lorusso, Fabrizio De Ponti and Carola Severi

    Citation: BMC Pharmacology and Toxicology 2018 19:49

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  18. Content type: Research article

    Guidelines recommending vancomycin trough concentrations > 10 mg/L in non-deep seated infections are based on expert opinion. The objective of this study was to evaluate patients with non-deep seated infection...

    Authors: Michael Wan, Sandra A. N. Walker, Elaine Martin, Marion Elligsen, Lesley Palmay and Jerome A. Leis

    Citation: BMC Pharmacology and Toxicology 2018 19:47

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  19. Content type: Research article

    Current studies have demonstrated that DODAC/PHO-S (Dioctadecyldimethylammonium Chloride/Synthetic phosphoethanolamine) liposomes induces cytotoxicity in Hepa1c1c7 and B16F10 murine tumor cells, with a higher ...

    Authors: Arthur Cássio de Lima Luna, Greice Kelle Viegas Saraiva, Gilberto Orivaldo Chierice, Henrique Hesse and Durvanei Augusto Maria

    Citation: BMC Pharmacology and Toxicology 2018 19:44

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  20. Content type: Research article

    Topical administration of PR022, 0.05% hypochlorous acid (HOCl) in gel has been demonstrated to be beneficial in a chronic murine atopic dermatitis model. In a follow up study we tested a higher concentration ...

    Authors: Tomoki Fukuyama, Sarah Ehling, Jenny Wilzopolski and Wolfgang Bäumer

    Citation: BMC Pharmacology and Toxicology 2018 19:37

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  21. Content type: Research article

    Cholangiocarcinoma (CCA), an epithelial malignancy of the biliary tree, is one of the aggressive cancers with poor prognosis and unsatisfactory response to chemotherapy with acquired resistance. NAD(P)H-quinon...

    Authors: Pimradasiri Srijiwangsa, Saranyoo Ponnikorn and Kesara Na-Bangchang

    Citation: BMC Pharmacology and Toxicology 2018 19:32

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  22. Content type: Research article

    Grifolic acid is a derivative of grifolin, an antitumor natural compound, and it was reported as an agonist of free fatty acid receptor GPR120. Little is known about its antitumor effects and the involvement o...

    Authors: Yufeng Zhao, Lei Zhang, Aili Yan, Di Chen, Rong Xie, Yingguang Liu, Xiangyan Liang, Yanyan Zhao, Lanlan Wei, Jun Yu, Xi Xu and Xingli Su

    Citation: BMC Pharmacology and Toxicology 2018 19:26

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  23. Content type: Research article

    Pueraria candollei var. mirifica is a medicinal plant that is promoted as a “Champion Product” by the Government of Thailand. This plant has been reported to relieve postmenopausal symptoms, prevent and reverse b...

    Authors: Tosapol Anukunwithaya, Pilaslak Poo, Natthaphon Hunsakunachai, Ratchanee Rodsiri, Suchinda Malaivijitnond and Phisit Khemawoot

    Citation: BMC Pharmacology and Toxicology 2018 19:25

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  24. Content type: Research article

    Based on accumulating evidence, the regulation of protein expression by antipsychotic drugs (APDs) might be closely related to the control of psychotic symptoms when these drugs are used to treat mental disord...

    Authors: Tinchou Li, Mingcheng Lee, Fuming Tsai, Yunhsiang Chen, Yiyin Lin and Maoliang Chen

    Citation: BMC Pharmacology and Toxicology 2018 19:9

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  25. Content type: Case report

    Clonidine is an imidazoline sympatholytic, acting on both α2-adrenergic and imidazoline receptors in the brainstem to induce antihypertensive and negative chronotropic effects in the vasculature and heart respect...

    Authors: Alexander J. Sandweiss, Christopher M. Morrison, Anne Spichler and John Rozich

    Citation: BMC Pharmacology and Toxicology 2018 19:6

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  26. Content type: Research article

    In the past decade several studies have reported that in some brain areas, particularly, in the midbrain periaqueductal gray matter, rostral ventro-medial medulla, central nucleus of amygdala, nucleus raphe ma...

    Authors: Nana Tsiklauri, Natia Pirkulashvili, Ivliane Nozadze, Marina Nebieridze, Gulnaz Gurtskaia, Elene Abzianidze and Merab G. Tsagareli

    Citation: BMC Pharmacology and Toxicology 2018 19:2

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  27. Content type: Research article

    γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain where it regulates activity of neuronal networks. The receptor for glucagon-like peptide-1 (GLP-1) is expressed in the hippocampu...

    Authors: Omar Babateen, Sergiy V. Korol, Zhe Jin, Amol K. Bhandage, Aikeremu Ahemaiti and Bryndis Birnir

    Citation: BMC Pharmacology and Toxicology 2017 18:83

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  28. Content type: Research article

    Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activat...

    Authors: Jui-Ting Chang, Yao-Jen Liang, Chia-Yu Hsu, Chao-Yi Chen, Po-Jung Chen, Yi-Feng Yang, Yen-Lin Chen, Dee Pei, Jin-Biou Chang and Jyh-Gang Leu

    Citation: BMC Pharmacology and Toxicology 2017 18:67

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  29. Content type: Research article

    Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estrog...

    Authors: Scott M. Belcher, Caleb C. Burton, Clifford J. Cookman, Michelle Kirby, Gabriel L. Miranda, Fatima O. Saeed and Kathleen E. Wray

    Citation: BMC Pharmacology and Toxicology 2017 18:63

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  30. Content type: Research article

    Isoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/AKT signaling pathway. However, both oxidative stress and activated PI3K/AKT signaling contribute to ...

    Authors: Tianbao Chen, Shaoxiong Deng and Rong Lin

    Citation: BMC Pharmacology and Toxicology 2017 18:57

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  33. Content type: Research article

    E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2H...

    Authors: Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu and Zhufang Shen

    Citation: BMC Pharmacology and Toxicology 2017 18:48

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  34. Content type: Research article

    The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the...

    Authors: Mariam A. Ba, Jeffrey Surina, Cherie A. Singer and Maria L. Valencik

    Citation: BMC Pharmacology and Toxicology 2017 18:47

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  35. Content type: Research article

    Diacetyl-liensinine is a chemosynthetic derivative of liensinine, extracted from the seed embryo of Nelumbo nucifera Gaertn, in China. It has been found to have extensive anti- arrhythmic actions. The present stu...

    Authors: Feng Cao, Teng Wang, Wenmao Ding, Zhe Li, Shaobo Shi and Xiaozhan Wang

    Citation: BMC Pharmacology and Toxicology 2017 18:33

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  36. Content type: Research article

    Drug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a tr...

    Authors: Gabriel Kigen and Geoffrey Edwards

    Citation: BMC Pharmacology and Toxicology 2017 18:20

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  37. Content type: Research article

    Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patie...

    Authors: Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie and Zhi-Jun Dai

    Citation: BMC Pharmacology and Toxicology 2017 18:30

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  38. Content type: Research article

    The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.

    Authors: Anayt Ulla, Mustafe Khalid Mohamed, Biswajit Sikder, AFM Towheedur Rahman, Farzana Akther Sumi, Murad Hossain, Hasan Mahmud Reza, G. M. Sayedur Rahman and Md Ashraful Alam

    Citation: BMC Pharmacology and Toxicology 2017 18:29

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  40. Content type: Research article

    Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (N...

    Authors: Seon Young Choi, Hang-Rae Kim, Pan Dong Ryu and So Yeong Lee

    Citation: BMC Pharmacology and Toxicology 2017 18:14

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  41. Content type: Research article

    Mitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a nat...

    Authors: Urara Ota, Takeshi Hara, Hitoshi Nakagawa, Emi Tsuru, Masayuki Tsuda, Atsuko Kamiya, Yasushi Kuroda, Yuya Kitajima, Aya Koda, Masahiro Ishizuka, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Motowo Nakajima and Tohru Tanaka

    Citation: BMC Pharmacology and Toxicology 2017 18:7

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  42. Content type: Research article

    Synthetic and natural antioxidants including Bacopa monnieri (L.) Pennell (Scrophulariaceae) which also possess anti-dopaminergic properties, have been proposed to be useful for emetogenic chemotherapy. In this s...

    Authors: Javaid Alam, Fazal Subhan, Ihsan Ullah, Muhammad Shahid, Gowhar Ali and Robert D. E. Sewell

    Citation: BMC Pharmacology and Toxicology 2017 18:4

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    The Erratum to this article has been published in BMC Pharmacology and Toxicology 2017 18:9

  43. Content type: Research article

    Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases.

    Authors: Victor Kuete, Leonidah K. Omosa, Viviane R. Sipowo Tala, Jacob O. Midiwo, Armelle T. Mbaveng, Sauda Swaleh, Oğuzhan Karaosmanoğlu and Hülya Sivas

    Citation: BMC Pharmacology and Toxicology 2016 17:60

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  44. Content type: Research article

    Praziquantel (PZQ) is an antihelminthic drug whose P-glycoprotein (P-gp) substrate specificity has not been conclusively characterized. We investigated its specificity by comparing its in vitro intracellular accu...

    Authors: Gabriel Kigen and Geoffrey Edwards

    Citation: BMC Pharmacology and Toxicology 2016 17:37

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  45. Content type: Research article

    Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was develop...

    Authors: Mohammad Alsalem, Paul Millns, Ahmad Altarifi, Khalid El-Salem, Victoria Chapman and David A. Kendall

    Citation: BMC Pharmacology and Toxicology 2016 17:31

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  46. Content type: Research article

    All hematopoietic cells express P2 receptors, however pharmacological characteristics such as expression and affinity in granulocytes are unknown.

    Authors: Antonio Carlos Ribeiro-Filho, Marcus Vinicius Buri, Carlos Castilho Barros, Juliana Luporini Dreyfuss, Helena Bonciani Nader, Giselle Zenker Justo, Rogério Bastos Craveiro, João Bosco Pesquero, Antonio Miranda, Alice Teixeira Ferreira and Edgar Julian Paredes-Gamero

    Citation: BMC Pharmacology and Toxicology 2016 17:29

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  47. Content type: Research article

    Previously, we have demonstrated that human ABCB5 is a full-sized ATP-binding cassette transporter that shares strong homology with ABCB1/P-glycoprotein. ABCB5-transfected cells showed resistance to taxanes and a...

    Authors: Shingo Kondo, Keita Hongama, Kengo Hanaya, Ryota Yoshida, Takaaki Kawanobe, Kazuhiro Katayama, Kohji Noguchi and Yoshikazu Sugimoto

    Citation: BMC Pharmacology and Toxicology 2015 16:37

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  48. Content type: Research article

    We have previously shown that the thromboxane (TXA2) receptor agonist, U46619, can directly induce ventricular arrhythmias that were associated with increases in intracellular calcium in cardiomyocytes. Since ...

    Authors: Chad D Touchberry, Neerupma Silswal, Vladimir Tchikrizov, Christopher J Elmore, Shubra Srinivas, Adil S Akthar, Hannah K Swan, Lori A Wetmore and Michael J Wacker

    Citation: BMC Pharmacology and Toxicology 2014 15:73

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  49. Content type: Research article

    The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme wi...

    Authors: Nicola Laurieri, Akane Kawamura, Isaac M Westwood, Amy Varney, Elizabeth Morris, Angela J Russell, Lesley A Stanley and Edith Sim

    Citation: BMC Pharmacology and Toxicology 2014 15:68

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  50. Content type: Research article

    Lung cancer is characterized by a high mortality rate probably attributable to early metastasis. Oxidative stress is involved in development and progression of lung cancer, through cellular and molecular mecha...

    Authors: Luca Gallelli, Daniela Falcone, Monica Scaramuzzino, Girolamo Pelaia, Bruno D’Agostino, Maria Mesuraca, Rosa Terracciano, Giuseppe Spaziano, Rosario Maselli, Michele Navarra and Rocco Savino

    Citation: BMC Pharmacology and Toxicology 2014 15:67

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