Skip to main content

Basic pharmacology

Section edited by David Farb

This section considers submissions that focus on receptor pharmacology, signal transduction, pharmacokinetics and pharmacogenomics relating to all organ systems.

Page 2 of 2

  1. E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2H...

    Authors: Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu and Zhufang Shen

    Citation: BMC Pharmacology and Toxicology 2017 18:48

    Content type: Research article

    Published on:

  2. The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the...

    Authors: Mariam A. Ba, Jeffrey Surina, Cherie A. Singer and Maria L. Valencik

    Citation: BMC Pharmacology and Toxicology 2017 18:47

    Content type: Research article

    Published on:

  3. Diacetyl-liensinine is a chemosynthetic derivative of liensinine, extracted from the seed embryo of Nelumbo nucifera Gaertn, in China. It has been found to have extensive anti- arrhythmic actions. The present stu...

    Authors: Feng Cao, Teng Wang, Wenmao Ding, Zhe Li, Shaobo Shi and Xiaozhan Wang

    Citation: BMC Pharmacology and Toxicology 2017 18:33

    Content type: Research article

    Published on:

  4. Drug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a tr...

    Authors: Gabriel Kigen and Geoffrey Edwards

    Citation: BMC Pharmacology and Toxicology 2017 18:20

    Content type: Research article

    Published on:

  5. Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patie...

    Authors: Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie and Zhi-Jun Dai

    Citation: BMC Pharmacology and Toxicology 2017 18:30

    Content type: Research article

    Published on:

  6. The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.

    Authors: Anayt Ulla, Mustafe Khalid Mohamed, Biswajit Sikder, AFM Towheedur Rahman, Farzana Akther Sumi, Murad Hossain, Hasan Mahmud Reza, G. M. Sayedur Rahman and Md Ashraful Alam

    Citation: BMC Pharmacology and Toxicology 2017 18:29

    Content type: Research article

    Published on:

  7. Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (N...

    Authors: Seon Young Choi, Hang-Rae Kim, Pan Dong Ryu and So Yeong Lee

    Citation: BMC Pharmacology and Toxicology 2017 18:14

    Content type: Research article

    Published on:

  8. Mitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a nat...

    Authors: Urara Ota, Takeshi Hara, Hitoshi Nakagawa, Emi Tsuru, Masayuki Tsuda, Atsuko Kamiya, Yasushi Kuroda, Yuya Kitajima, Aya Koda, Masahiro Ishizuka, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Motowo Nakajima and Tohru Tanaka

    Citation: BMC Pharmacology and Toxicology 2017 18:7

    Content type: Research article

    Published on:

  9. Synthetic and natural antioxidants including Bacopa monnieri (L.) Pennell (Scrophulariaceae) which also possess anti-dopaminergic properties, have been proposed to be useful for emetogenic chemotherapy. In this s...

    Authors: Javaid Alam, Fazal Subhan, Ihsan Ullah, Muhammad Shahid, Gowhar Ali and Robert D. E. Sewell

    Citation: BMC Pharmacology and Toxicology 2017 18:4

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Pharmacology and Toxicology 2017 18:9

  10. Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases.

    Authors: Victor Kuete, Leonidah K. Omosa, Viviane R. Sipowo Tala, Jacob O. Midiwo, Armelle T. Mbaveng, Sauda Swaleh, Oğuzhan Karaosmanoğlu and Hülya Sivas

    Citation: BMC Pharmacology and Toxicology 2016 17:60

    Content type: Research article

    Published on:

  11. Praziquantel (PZQ) is an antihelminthic drug whose P-glycoprotein (P-gp) substrate specificity has not been conclusively characterized. We investigated its specificity by comparing its in vitro intracellular accu...

    Authors: Gabriel Kigen and Geoffrey Edwards

    Citation: BMC Pharmacology and Toxicology 2016 17:37

    Content type: Research article

    Published on:

  12. Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was develop...

    Authors: Mohammad Alsalem, Paul Millns, Ahmad Altarifi, Khalid El-Salem, Victoria Chapman and David A. Kendall

    Citation: BMC Pharmacology and Toxicology 2016 17:31

    Content type: Research article

    Published on:

  13. All hematopoietic cells express P2 receptors, however pharmacological characteristics such as expression and affinity in granulocytes are unknown.

    Authors: Antonio Carlos Ribeiro-Filho, Marcus Vinicius Buri, Carlos Castilho Barros, Juliana Luporini Dreyfuss, Helena Bonciani Nader, Giselle Zenker Justo, Rogério Bastos Craveiro, João Bosco Pesquero, Antonio Miranda, Alice Teixeira Ferreira and Edgar Julian Paredes-Gamero

    Citation: BMC Pharmacology and Toxicology 2016 17:29

    Content type: Research article

    Published on:

  14. Previously, we have demonstrated that human ABCB5 is a full-sized ATP-binding cassette transporter that shares strong homology with ABCB1/P-glycoprotein. ABCB5-transfected cells showed resistance to taxanes and a...

    Authors: Shingo Kondo, Keita Hongama, Kengo Hanaya, Ryota Yoshida, Takaaki Kawanobe, Kazuhiro Katayama, Kohji Noguchi and Yoshikazu Sugimoto

    Citation: BMC Pharmacology and Toxicology 2015 16:37

    Content type: Research article

    Published on:

  15. We have previously shown that the thromboxane (TXA2) receptor agonist, U46619, can directly induce ventricular arrhythmias that were associated with increases in intracellular calcium in cardiomyocytes. Since ...

    Authors: Chad D Touchberry, Neerupma Silswal, Vladimir Tchikrizov, Christopher J Elmore, Shubra Srinivas, Adil S Akthar, Hannah K Swan, Lori A Wetmore and Michael J Wacker

    Citation: BMC Pharmacology and Toxicology 2014 15:73

    Content type: Research article

    Published on:

  16. The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme wi...

    Authors: Nicola Laurieri, Akane Kawamura, Isaac M Westwood, Amy Varney, Elizabeth Morris, Angela J Russell, Lesley A Stanley and Edith Sim

    Citation: BMC Pharmacology and Toxicology 2014 15:68

    Content type: Research article

    Published on:

  17. Lung cancer is characterized by a high mortality rate probably attributable to early metastasis. Oxidative stress is involved in development and progression of lung cancer, through cellular and molecular mecha...

    Authors: Luca Gallelli, Daniela Falcone, Monica Scaramuzzino, Girolamo Pelaia, Bruno D’Agostino, Maria Mesuraca, Rosa Terracciano, Giuseppe Spaziano, Rosario Maselli, Michele Navarra and Rocco Savino

    Citation: BMC Pharmacology and Toxicology 2014 15:67

    Content type: Research article

    Published on:

  18. Nobiletin is a non-toxic dietary flavonoid that possesses anti-cancer properties. Nobiletin has been reported to reduce the risk of prostate cancer, but the mechanism is not well understood. In this study, we ...

    Authors: Jianchu Chen, Ashley Creed, Allen Y Chen, Haizhi Huang, Zhaoliang Li, Gary O Rankin, Xingqian Ye, Guihua Xu and Yi Charlie Chen

    Citation: BMC Pharmacology and Toxicology 2014 15:59

    Content type: Research article

    Published on:

  19. 11ß–hydroxysteroid dehydrogenase type1 (11β-HSD1) converts inactive glucocorticoids to active glucocorticoids which, in excess, leads to development of the various risk factors of the metabolic syndrome. Recen...

    Authors: Tharappel M Anil, Anilkumar Dandu, KrishnaReddy Harsha, Jaideep Singh, Nitya Shree, Venkatesh Satish Kumar, Mudigere N Lakshmi, Venkategowda Sunil, Chandrashekaran Harish, Gundalmandikal V Balamurali, Baisani S Naveen Kumar, Aralakuppe S Gopala, Shivakumar Pratibha, ManojKumar Sadasivuni, Mammen O Anup, Yoganand Moolemath…

    Citation: BMC Pharmacology and Toxicology 2014 15:43

    Content type: Research article

    Published on:

  20. Activation of peroxisome proliferator-activated receptor (PPAR)α and PPARδ causes an elevation of tissue carnitine concentrations through induction of genes involved in carnitine uptake [novel organic cation t...

    Authors: Aline Couturier, Robert Ringseis, Erika Most and Klaus Eder

    Citation: BMC Pharmacology and Toxicology 2014 15:37

    Content type: Research article

    Published on:

  21. Glucocorticoids affect peripheral immune responses, including modulation of T-cell activation, differentiation, and apoptosis. The quantity and quality of T-cell receptor (TCR)-triggered intracellular signals ...

    Authors: Maria Grazia Petrillo, Katia Fettucciari, Paolo Montuschi, Simona Ronchetti, Luigi Cari, Graziella Migliorati, Emanuela Mazzon, Oxana Bereshchenko, Stefano Bruscoli, Giuseppe Nocentini and Carlo Riccardi

    Citation: BMC Pharmacology and Toxicology 2014 15:35

    Content type: Research article

    Published on:

  22. Cannabinoid receptor 2 (CB2) is expressed predominantly in the immune system, particularly in plasma cells, raising the possibility that targeting the CB2 pathway could yield an immunomodulatory effect. Althou...

    Authors: Rentian Feng, Christine A Milcarek and Xiang-Qun Xie

    Citation: BMC Pharmacology and Toxicology 2014 15:30

    Content type: Research article

    Published on:

  23. Regulator of G protein signaling (RGS) proteins suppress G protein coupled receptor signaling by catalyzing the hydrolysis of Gα-bound guanine nucleotide triphosphate. Transgenic mice in which RGS-mediated reg...

    Authors: Sergio Parra, Xinyan Huang, Raelene A Charbeneau, Susan M Wade, Kuljeet Kaur, Boyd R Rorabaugh and Richard R Neubig

    Citation: BMC Pharmacology and Toxicology 2014 15:29

    Content type: Research article

    Published on:

  24. Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcohol...

    Authors: Thuc T Le, Yasuyo Urasaki and Giuseppe Pizzorno

    Citation: BMC Pharmacology and Toxicology 2014 15:27

    Content type: Research article

    Published on:

  25. Novobiocin is a coumarin antibiotic, which affects also eukaryotic cells inhibiting activity of Heat shock protein 90 (Hsp90). The Hsp90 represents a molecular chaperone critical for stabilization and activati...

    Authors: Anna K Szkaradkiewicz, Tomasz M Karpiński and Andrzej Szkaradkiewicz

    Citation: BMC Pharmacology and Toxicology 2014 15:25

    Content type: Research article

    Published on:

  26. GPR40 is a G-protein coupled receptor regulating free fatty acid induced and also glucose induced insulin secretion. We generated neonatally-streptozotocin-treated female rats (n-STZ) and treated them with CNX...

    Authors: Venkategowda Sunil, Mahesh Kumar Verma, Anup M Oommen, Manojkumar Sadasivuni, Jaideep Singh, Dasarahalli N Vijayraghav, Bhawna Chandravanshi, Jayalaxmi Shetty, Sanghamitra Biswas, Anilkumar Dandu, Yoganand Moolemath, Marikunte V Venkataranganna, Baggavalli P Somesh and Madanahalli R Jagannath

    Citation: BMC Pharmacology and Toxicology 2014 15:19

    Content type: Research article

    Published on:

  27. Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain are...

    Authors: Gulnazi Gurtskaia, Nana Tsiklauri, Ivliane Nozadze, Marina Nebieridze and Merab G Tsagareli

    Citation: BMC Pharmacology and Toxicology 2014 15:10

    Content type: Research article

    Published on:

  28. Indoxyl sulfate (IS), an organic anion uremic toxin, promotes the progression of renal dysfunction. Some studies have suggested that IS inhibits osteoclast differentiation and suppresses parathyroid hormone (P...

    Authors: Young-Hee Kim, Kyung-Ah Kwak, Hyo-Wook Gil, Ho-Yeon Song and Sae-Yong Hong

    Citation: BMC Pharmacology and Toxicology 2013 14:60

    Content type: Research article

    Published on:

  29. Chemotherapy-induced hair loss (alopecia) (CIA) is one of the most feared side effects of chemotherapy among cancer patients. There is currently no pharmacological approach to minimize CIA, although one strate...

    Authors: Zeina Nasr, Lukas E Dow, Marilene Paquet, Jennifer Chu, Kontham Ravindar, Ragam Somaiah, Pierre Deslongchamps, John A Porco Jr, Scott W Lowe and Jerry Pelletier

    Citation: BMC Pharmacology and Toxicology 2013 14:58

    Content type: Research article

    Published on:

  30. Dipyrithione (PTS2) is widely used as a bactericide and fungicide. Here, we investigated whether PTS2 has broad-spectrum antitumor activity by studying its cytotoxicity and proapoptotic effects in four cancer ...

    Authors: Yumei Fan, Caizhi Liu, Yongmao Huang, Jie Zhang, Linlin Cai, Shengnan Wang, Yongze Zhang, Xianglin Duan and Zhimin Yin

    Citation: BMC Pharmacology and Toxicology 2013 14:54

    Content type: Research article

    Published on:

  31. Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebiv...

    Authors: R Preston Mason, Robert F Jacob, J Jose Corbalan, Damian Szczesny, Kinga Matysiak and Tadeusz Malinski

    Citation: BMC Pharmacology and Toxicology 2013 14:48

    Content type: Research article

    Published on:

  32. Raltegravir (Isentress®)(RALT) has demonstrated excellent efficacy in both treatment-experienced and naïve patients with HIV-1 infection, and is the first strand transfer integrase inhibitor to be approved for...

    Authors: Maria Luisa Dupuis, Alessandro Ascione, Lucia Palmisano, Stefano Vella and Maurizio Cianfriglia

    Citation: BMC Pharmacology and Toxicology 2013 14:47

    Content type: Research article

    Published on:

  33. Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs under...

    Authors: Ahmed E Enayetallah, Dinesh Puppala, Daniel Ziemek, James E Fischer, Sheila Kantesaria and Mathew T Pletcher

    Citation: BMC Pharmacology and Toxicology 2013 14:46

    Content type: Research article

    Published on:

  34. The γ-aminobutyric acid (GABA) type A receptor (GABAAR) contains the recognition sites for a variety of agents used in the treatment of brain disorders, including anxiety and epilepsy. A better understanding of h...

    Authors: Shamol Saha, Yinghui Hu, Stella C Martin, Sabita Bandyopadhyay, Shelley J Russek and David H Farb

    Citation: BMC Pharmacology and Toxicology 2013 14:37

    Content type: Research article

    Published on:

  35. Casein kinase 2 (CK2) is involved in various cellular events such as proliferation, apoptosis, and the cell cycle. CK2 overexpression is associated with multiple human cancers and may therefore be a promising ...

    Authors: Shu Liu, David Hsieh, Yi-Lin Yang, Zhidong Xu, Csaba Peto, David M Jablons and Liang You

    Citation: BMC Pharmacology and Toxicology 2013 14:36

    Content type: Research article

    Published on:

  36. Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is li...

    Authors: Therese Bredholt, Elisabeth Ersvær, Bjarte Skoe Erikstein, André Sulen, Håkon Reikvam, Hans Jørgen Aarstad, Anne Christine Johannessen, Olav Karsten Vintermyr, Øystein Bruserud and Bjørn Tore Gjertsen

    Citation: BMC Pharmacology and Toxicology 2013 14:35

    Content type: Research article

    Published on:

  37. Dormant cells are characterised by low RNA synthesis. In contrast, cancer cells can be addicted to high RNA synthesis, including synthesis of survival molecules. We hypothesised that dormant cancer cells, alre...

    Authors: Monica Pallis, Francis Burrows, Abigail Whittall, Nicholas Boddy, Claire Seedhouse and Nigel Russell

    Citation: BMC Pharmacology and Toxicology 2013 14:32

    Content type: Research article

    Published on:

  38. Platinum derivatives are used widely for the treatment of many cancers. However, the toxicity that is observed makes imperative the need for new drugs, or new combinations. Anvirzel™ is an extract which has be...

    Authors: Panagiotis Apostolou, Maria Toloudi, Marina Chatziioannou, Eleni Ioannou, Dennis R Knocke, Joe Nester, Dimitrios Komiotis and Ioannis Papasotiriou

    Citation: BMC Pharmacology and Toxicology 2013 14:18

    Content type: Research article

    Published on:

  39. Cocaine exposure has been reported to alter central μ-opioid receptor (MOR) expression in vivo. The present study employed an in vitro cellular model to explore possible mechanisms that may be involved in this ac...

    Authors: Warren Winick-Ng, Francesco Leri and Bettina E Kalisch

    Citation: BMC Pharmacology and Toxicology 2012 13:11

    Content type: Research article

    Published on:

2019 Journal Metrics