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BMC Pharmacology and Toxicology

Clinical pharmacology

Section edited by Catherine Sherwin 

This section considers submissions that focus on all areas of clinical pharmacology including rational prescribing, pharmacoeconomics, pharmacovigillance, pharmacoepidemiology and clinical trials.

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  1. Content type: Research article

    Metolazone is a diuretic, saluretic and antihypertensive chemical compound from the quinazoline category that possesses medicinal features similar to those of other thiazide diuretic drugs. However, the pharma...

    Authors: Xueqing Li, Rutao Wang, Yang Liu, Yun Liu, Heng Zheng, Yabo Feng, Na Zhao, Hongbin Geng, Wanzhi Zhang and Aidong Wen

    Citation: BMC Pharmacology and Toxicology 2017 18:73

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  2. Content type: Research article

    Although there are systems for reporting adverse drug reactions (ADR), these safety events remain under reported. The low-cost, low-tech trigger tool method is based on the detection of events through clues, and ...

    Authors: Silvana Maria de Almeida, Aruana Romualdo, Andressa de Abreu Ferraresi, Giovana Roberta Zelezoglo, Alexandre R. Marra and Michael B. Edmond

    Citation: BMC Pharmacology and Toxicology 2017 18:71

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  3. Content type: Study protocol

    It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated. The developm...

    Authors: Célia Lloret-Linares, Youssef Daali, Sylvie Chevret, Isabelle Nieto, Fanny Molière, Philippe Courtet, Florence Galtier, Raphaëlle-Marie Richieri, Sophie Morange, Pierre-Michel Llorca, Wissam El-Hage, Thomas Desmidt, Frédéric Haesebaert, Philippe Vignaud, Jerôme Holtzmann, Jean-Luc Cracowski…

    Citation: BMC Pharmacology and Toxicology 2017 18:70

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  4. Content type: Research article

    Older people have a greater disease burden and are more likely than younger to be prescribed medications. They are also more sensitive to adverse effects. With this in mind, a range of medications have been su...

    Authors: Anna Axmon, Magnus Sandberg, Gerd Ahlström and Patrik Midlöv

    Citation: BMC Pharmacology and Toxicology 2017 18:68

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  5. Content type: Research article

    Vildagliptin and pioglitazone/rosiglitazone are emerging Oral Hypoglycemic Agents (OHAs) which are used to treat patients suffering from Type 2 Diabetes Mellitus (T2DM). In this analysis, we aimed to systemati...

    Authors: Pravesh Kumar Bundhun, Girish Janoo, Abhishek Rishikesh Teeluck and Feng Huang

    Citation: BMC Pharmacology and Toxicology 2017 18:66

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  6. Content type: Research article

    Thiazolidinediones (TZDs), peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, exhibit anti-inflammatory and antioxidant properties and inhibit endothelial inflammation and dysfunction, which is an...

    Authors: Yun Hyi Ku, Bong-Jun Cho, Min Joo Kim, Soo Lim, Young Joo Park, Hak C. Jang and Sung Hee Choi

    Citation: BMC Pharmacology and Toxicology 2017 18:62

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  7. Content type: Study protocol

    An estimated 2.7 of the 5.9 million deaths in children under 5 years of age occur in the neonatal period. Severe infections contribute to almost a quarter of these deaths. Mortality due to severe infections in...

    Authors: Nitya Wadhwa, Sudha Basnet, Uma Chandra Mouli Natchu, Laxman P. Shrestha, Shinjini Bhatnagar, Halvor Sommerfelt, Tor A. Strand, Siddarth Ramji, K. C. Aggarwal, Harish Chellani, Anuradha Govil, Mamta Jajoo, N. B. Mathur, Meenakshi Bhatt, Anup Mohta, Imran Ansari…

    Citation: BMC Pharmacology and Toxicology 2017 18:56

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  8. Content type: Research article

    Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose...

    Authors: Shijia Liu, Peidong Chen, Yang Zhao, Guoliang Dai, Bingting Sun, Yao Wang, Anwei Ding and Wenzheng Ju

    Citation: BMC Pharmacology and Toxicology 2017 18:54

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  9. Content type: Research article

    The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use unde...

    Authors: Huan Fang, Xiaowen Lin, Jun Zhang, Zhen Hong, Kenji Sugiyama, Takao Nozaki, Tetsuro Sameshima, Susumu Kobayashi, Hiroki Namba and Tetsuya Asakawa

    Citation: BMC Pharmacology and Toxicology 2017 18:49

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  10. Content type: Research article

    Increased pain sensitivity is a putative risk factor for chronic pain and consequently for analgesic use. Conversely, analgesic use may be a cause of increased pain sensitivity, e.g., through opioid-induced hy...

    Authors: Per-Jostein Samuelsen, Christopher Sivert Nielsen, Tom Wilsgaard, Audun Stubhaug, Kristian Svendsen and Anne Elise Eggen

    Citation: BMC Pharmacology and Toxicology 2017 18:45

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  11. Content type: Research article

    Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from the α-galactosidase A gene mutations. Enzyme-replacement-therapy (ERT) products for FD currently used include agalsidase alfa and aga...

    Authors: Kazuya Tsuboi and Hiroshi Yamamoto

    Citation: BMC Pharmacology and Toxicology 2017 18:43

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  12. Content type: Research article

    Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to...

    Authors: Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim and Yngve Gustafson

    Citation: BMC Pharmacology and Toxicology 2017 18:36

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  13. Content type: Research article

    Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a ...

    Authors: Serawit Deyno, Alemayehu Toma, Mesfin Worku and Muluken Bekele

    Citation: BMC Pharmacology and Toxicology 2017 18:35

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  14. Content type: Research article

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung ...

    Authors: Chih-Jen Yang, Jen-Yu Hung, Ming-Ju Tsai, Kuan-Li Wu, Ta-Chih Liu, Shah-Hwa Chou, Jui-Ying Lee, Jui-Sheng Hsu, Ming-Shyan Huang and Inn-Wen Chong

    Citation: BMC Pharmacology and Toxicology 2017 18:21

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  15. Content type: Research article

    The aim of this study is to identify the distribution by municipalities of adverse drug events (ADE) in Portugal, including adverse drug reactions (ADR) and accidental poisoning by drugs (AP), on municipality/...

    Authors: Gianina Scripcaru, Ceu Mateus and Carla Nunes

    Citation: BMC Pharmacology and Toxicology 2017 18:34

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  16. Content type: Research article

    Nowadays, canagliflozin monotherapy, or in combination with other oral hypoglycemic agents (OHAs), is often administered in patients who are treated for type 2 diabetes mellitus (T2DM). Therefore, we aimed to ...

    Authors: Pravesh Kumar Bundhun, Girish Janoo and Feng Huang

    Citation: BMC Pharmacology and Toxicology 2017 18:19

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  17. Content type: Research article

    Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition to blood glucose-lowering effect, however, its mechanism is still unknown. This study aimed to investigate ...

    Authors: Shin Kawasoe, Yukiko Maruguchi, Shoko Kajiya, Hitoshi Uenomachi, Masaaki Miyata, Mariko Kawasoe, Takuro Kubozono and Mitsuru Ohishi

    Citation: BMC Pharmacology and Toxicology 2017 18:23

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  18. Content type: Research article

    Adherence to prescribed medication is an imperative issue which can be directly linked with the management of chronic diseases like hypertension; failure to adhere can affect the effectiveness of medication as...

    Authors: Habtamu Sewunet Mekonnen, Mignote Hailu Gebrie, Kokeb Haile Eyasu and Abebaw Addis Gelagay

    Citation: BMC Pharmacology and Toxicology 2017 18:27

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  19. Content type: Research article

    Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treat...

    Authors: Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado and David Cox

    Citation: BMC Pharmacology and Toxicology 2017 18:22

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