Clinical pharmacology

Section edited by Catherine Sherwin 

This section considers submissions that focus on all areas of clinical pharmacology including rational prescribing, pharmacoeconomics, pharmacovigillance, pharmacoepidemiology and clinical trials.

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  1. Study protocol

    Zinc as an adjunct treatment for reducing case fatality due to clinical severe infection in young infants: study protocol for a randomized controlled trial

    An estimated 2.7 of the 5.9 million deaths in children under 5 years of age occur in the neonatal period. Severe infections contribute to almost a quarter of these deaths. Mortality due to severe infections in...

    Nitya Wadhwa, Sudha Basnet, Uma Chandra Mouli Natchu, Laxman P. Shrestha, Shinjini Bhatnagar, Halvor Sommerfelt, Tor A. Strand, Siddarth Ramji, K. C. Aggarwal, Harish Chellani, Anuradha Govil, Mamta Jajoo, N. B. Mathur, Meenakshi Bhatt, Anup Mohta, Imran Ansari…

    BMC Pharmacology and Toxicology 2017 18:56

    Published on: 10 July 2017

  2. Research article

    Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

    Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose...

    Shijia Liu, Peidong Chen, Yang Zhao, Guoliang Dai, Bingting Sun, Yao Wang, Anwei Ding and Wenzheng Ju

    BMC Pharmacology and Toxicology 2017 18:54

    Published on: 4 July 2017

  3. Research article

    Drug-related problems and medication reviews among old people with dementia

    Drug-related problems, including medication errors and adverse drug events, are common among old people. Due to, for example, greater susceptibility to side effects, people with dementia are even more at risk ...

    Bettina Pfister, Jeanette Jonsson and Maria Gustafsson

    BMC Pharmacology and Toxicology 2017 18:52

    Published on: 27 June 2017

  4. Research article

    Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China

    The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use unde...

    Huan Fang, Xiaowen Lin, Jun Zhang, Zhen Hong, Kenji Sugiyama, Takao Nozaki, Tetsuro Sameshima, Susumu Kobayashi, Hiroki Namba and Tetsuya Asakawa

    BMC Pharmacology and Toxicology 2017 18:49

    Published on: 26 June 2017

  5. Research article

    Pain sensitivity and analgesic use among 10,486 adults: the Tromsø study

    Increased pain sensitivity is a putative risk factor for chronic pain and consequently for analgesic use. Conversely, analgesic use may be a cause of increased pain sensitivity, e.g., through opioid-induced hy...

    Per-Jostein Samuelsen, Christopher Sivert Nielsen, Tom Wilsgaard, Audun Stubhaug, Kristian Svendsen and Anne Elise Eggen

    BMC Pharmacology and Toxicology 2017 18:45

    Published on: 9 June 2017

  6. Research article

    Psychotropic drug use and mortality in old people with dementia: investigating sex differences

    Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to...

    Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim and Yngve Gustafson

    BMC Pharmacology and Toxicology 2017 18:36

    Published on: 25 May 2017

  7. Research article

    Antimicrobial resistance profile of Staphylococcus aureus isolates isolated from ear discharges of patients at University of Hawassa comprehensive specialized hospital

    Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a ...

    Serawit Deyno, Alemayehu Toma, Mesfin Worku and Muluken Bekele

    BMC Pharmacology and Toxicology 2017 18:35

    Published on: 15 May 2017

  8. Research article

    The salvage therapy in lung adenocarcinoma initially harbored susceptible EGFR mutation and acquired resistance occurred to the first-line gefitinib and second-line cytotoxic chemotherapy

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung ...

    Chih-Jen Yang, Jen-Yu Hung, Ming-Ju Tsai, Kuan-Li Wu, Ta-Chih Liu, Shah-Hwa Chou, Jui-Ying Lee, Jui-Sheng Hsu, Ming-Shyan Huang and Inn-Wen Chong

    BMC Pharmacology and Toxicology 2017 18:21

    Published on: 10 May 2017

  9. Research article

    Adverse drug events observed in patients with type 2 diabetes mellitus treated with 100 mg versus 300 mg canagliflozin: a systematic review and meta-analysis of published randomized controlled trials

    Nowadays, canagliflozin monotherapy, or in combination with other oral hypoglycemic agents (OHAs), is often administered in patients who are treated for type 2 diabetes mellitus (T2DM). Therefore, we aimed to ...

    Pravesh Kumar Bundhun, Girish Janoo and Feng Huang

    BMC Pharmacology and Toxicology 2017 18:19

    Published on: 16 April 2017

  10. Research article

    Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes

    Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition to blood glucose-lowering effect, however, its mechanism is still unknown. This study aimed to investigate ...

    Shin Kawasoe, Yukiko Maruguchi, Shoko Kajiya, Hitoshi Uenomachi, Masaaki Miyata, Mariko Kawasoe, Takuro Kubozono and Mitsuru Ohishi

    BMC Pharmacology and Toxicology 2017 18:23

    Published on: 10 April 2017

  11. Research article

    Drug adherence for antihypertensive medications and its determinants among adult hypertensive patients attending in chronic clinics of referral hospitals in Northwest Ethiopia

    Adherence to prescribed medication is an imperative issue which can be directly linked with the management of chronic diseases like hypertension; failure to adhere can affect the effectiveness of medication as...

    Habtamu Sewunet Mekonnen, Mignote Hailu Gebrie, Kokeb Haile Eyasu and Abebaw Addis Gelagay

    BMC Pharmacology and Toxicology 2017 18:27

    Published on: 5 April 2017

  12. Research article

    Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis

    Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treat...

    Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado and David Cox

    BMC Pharmacology and Toxicology 2017 18:22

    Published on: 4 April 2017

  13. Research article

    Pharmacokinetics of surotomycin from phase 1 single and multiple ascending dose studies in healthy volunteers

    Surotomycin, a novel, orally administered, cyclic, lipopeptide antibacterial in development for the treatment of Clostridium difficile-associated diarrhea, has demonstrated minimal intestinal absorption in animal...

    Gurudatt Chandorkar, Qiao Zhan, Julie Donovan, Shruta Rege and Hernando Patino

    BMC Pharmacology and Toxicology 2017 18:24

    Published on: 28 March 2017

  14. Case report

    Methimazole associated eosinophilic pleural effusion: a case report

    Adverse reactions associated to anti-thyroid drugs include fever, rash, arthralgia, agranulocytosis and hepatitis that are thought to be hypersensitivity reactions. Five cases of pleural effusion associated to...

    Pedro Gaspar-da-Costa, Filipa Duarte Silva, Júlia Henriques, Sónia do Vale, Sandra Braz, João Meneses Santos and Rui M.M. Victorino

    BMC Pharmacology and Toxicology 2017 18:16

    Published on: 21 March 2017

  15. Research article

    Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression

    Clarithromycin (CAM), a representative macrolide antibiotic, has been used widely at low doses for long-term therapy of chronic inflammatory airway diseases. Anti-inflammatory effects of macrolide antibiotics ...

    Kuninori Iwayama, Ayuko Kusakabe, Keisuke Ohtsu, Takahiro Nawano, Ryosuke Tatsunami, Ko-ichi Ohtaki, Yoshiko Tampo and Nobumasa Hayase

    BMC Pharmacology and Toxicology 2017 18:15

    Published on: 25 February 2017

  16. Research article

    Antibiotic use practices of pharmacy staff: a cross-sectional study in Saint Petersburg, the Russian Federation

    Non-prescription access to antimicrobials is common, and self-prescribing is increasingly popular in Russian society. The aim of this study was to assess the attitudes of community pharmacists regarding antibi...

    Tatiana Belkina, Natalia Duvanova, Julia Karbovskaja, Jurjen Duintjer Tebbens and Jiri Vlcek

    BMC Pharmacology and Toxicology 2017 18:11

    Published on: 14 February 2017

  17. Research article

    The efficacy and safety of co-administration of fimasartan and rosuvastatin to patients with hypertension and dyslipidemia

    Hypertension and dyslipidemia are major risk factors of cardiovascular disease (CVD) events. The objective of this study was to evaluate the efficacy and safety of the co-administration of fimasartan and rosuv...

    Moo-Yong Rhee, Taehoon Ahn, Kiyuk Chang, Shung Chull Chae, Tae-Hyun Yang, Wan Joo Shim, Tae Soo Kang, Jae-Kean Ryu, Deuk-Young Nah, Tae-Ho Park, In-Ho Chae, Seung Woo Park, Hae-Young Lee, Seung-Jea Tahk, Young Won Yoon, Chi Young Shim…

    BMC Pharmacology and Toxicology 2017 18:2

    Published on: 5 January 2017

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