Skip to main content

Clinical pharmacology

Section edited by Catherine Sherwin 

This section considers submissions that focus on all areas of clinical pharmacology including rational prescribing, pharmacoeconomics, pharmacovigillance, pharmacoepidemiology and clinical trials.

Page 4 of 5

  1. The choice of vasopressor use in the intensive care unit (ICU) depends primarily on provider preference. This study aims to describe the rate of vasopressor utilization and the trends of each vasoactive agent ...

    Authors: Charat Thongprayoon, Wisit Cheungpasitporn, Andrew M. Harrison, Perliveh Carrera, Narat Srivali, Wonngarm Kittamongkolchai, Aysen Erdogan and Kianoush B. Kashani

    Citation: BMC Pharmacology and Toxicology 2016 17:19

    Content type: Research article

    Published on:

  2. Abatacept (ABA) is a fusion receptor protein containing the CTLA-4 domain that prevents the activation of naïve T cells by binding the CD80 and CD86 molecules expressed on the surface of dendritic cells, indic...

    Authors: Rossella Talotta, Fabiola Atzeni and Piercarlo Sarzi Puttini

    Citation: BMC Pharmacology and Toxicology 2016 17:17

    Content type: Case report

    Published on:

  3. Opioid maintenance treatment with methadone is regarded as gold standard in the therapy of opioid dependence. Identification of the ‘right’ methadone dose, however, remains challenging. We wanted to explore if...

    Authors: Stephan Walcher, John Koc, Volker Reichel, Frank Schlote, Uwe Verthein and Jens Reimer

    Citation: BMC Pharmacology and Toxicology 2016 17:15

    Content type: Research article

    Published on:

  4. Chronic infection with Burkholderia cepacia complex (BCC) has a detrimental effect on morbidity and mortality for patients with cystic fibrosis (CF). It is therefore logical to attempt to eradicate new isolate...

    Authors: H. Kitt, W. Lenney and F. J. Gilchrist

    Citation: BMC Pharmacology and Toxicology 2016 17:14

    Content type: Case report

    Published on:

  5. Many antibiotics have no effect on Gram-positive and Gram-negative microbes, which necessitates the prescription of broad-spectrum antimicrobial agents that can lead to increased risk of antibiotic resistance....

    Authors: Josef Yayan, Beniam Ghebremedhin and Kurt Rasche

    Citation: BMC Pharmacology and Toxicology 2016 17:10

    Content type: Research article

    Published on:

  6. Although the pathophysiological mechanisms of arterial hypertension are different in obese and lean patients, hypertension guidelines do not include specific recommendations for obesity-related hypertension and, ...

    Authors: Mauro Cataldi, Ornella di Geronimo, Rossella Trio, Antonella Scotti, Andrea Memoli, Domenico Capone and Bruna Guida

    Citation: BMC Pharmacology and Toxicology 2016 17:9

    Content type: Research article

    Published on:

  7. Ceftriaxone is one of the most commonly used antibiotics due to its high antibacterial potency, wide spectrum of activity and low potential for toxicity. However, the global trend shows misuse of this drug. Th...

    Authors: Alemayehu Sileshi, Admasu Tenna, Mamo Feyissa and Workineh Shibeshi

    Citation: BMC Pharmacology and Toxicology 2016 17:7

    Content type: Research article

    Published on:

  8. Antimicrobial prophylaxis reduces the incidence of postoperative wound infections especially among patients undergoing orthopedics surgery. However, there is dearth of information on the clinical effectiveness...

    Authors: Joel M. Marwa, Isidor H. Ngayomela, Jeremiah Seni and Stephen E. Mshana

    Citation: BMC Pharmacology and Toxicology 2015 16:42

    Content type: Research article

    Published on:

  9. Literature shows that continuity of care from a primary care physician is associated with better patient satisfaction and preventive care. This may also have an effect on patients’ use of antibiotics. This stu...

    Authors: Tai Pong Lam, Yuk Tsan Wun, Kwok Fai Lam and Kai Sing Sun

    Citation: BMC Pharmacology and Toxicology 2015 16:40

    Content type: Research article

    Published on:

  10. Amikacin and kanamycin are mainly used for treating multidrug-resistant tuberculosis (MDR-TB), especially in developing countries where the burden of MDR-TB is highest. Their protracted use in MDR-TB treatment...

    Authors: Evans L. Sagwa, Nunurai Ruswa, Farai Mavhunga, Timothy Rennie, Hubert G. M. Leufkens and Aukje K. Mantel-Teeuwisse

    Citation: BMC Pharmacology and Toxicology 2015 16:36

    Content type: Research article

    Published on:

  11. Increasing recognition of Attention Deficit Hyperactivity Disorder (ADHD) among Aboriginal children, adolescents and young adults is a public health challenge. We investigated the pattern of prescription stimu...

    Authors: Manonita Ghosh, C. D’Arcy J. Holman and David B. Preen

    Citation: BMC Pharmacology and Toxicology 2015 16:35

    Content type: Research article

    Published on:

  12. Interpreting clinical guideline adherence and the appropriateness of medication regimens requires consideration of individual patient and caregiver factors. Factors leading to initiation of a medication may di...

    Authors: Sophia L. Johnson, Mari Palta, Christie M. Bartels, Carolyn T. Thorpe, Jennifer M. Weiss and Maureen A. Smith

    Citation: BMC Pharmacology and Toxicology 2015 16:34

    Content type: Research article

    Published on:

  13. Resistance to extended-spectrum cephalosporins among Enterobacteriaceae has been reported yet they serve as the last line treatment for severe infections in Uganda and other countries. This resistance often le...

    Authors: John N Kateregga, Ronah Kantume, Collins Atuhaire, Musisi Nathan Lubowa and James G Ndukui

    Citation: BMC Pharmacology and Toxicology 2015 16:14

    Content type: Research article

    Published on:

  14. Cytarabine is used in the treatment of acute myeloid leukemia (AML). Low-dose cytarabine can be combined with valproic acid and all-trans retinoic acid (ATRA) as AML-stabilizing treatment. We have investigated...

    Authors: Elisabeth Ersvaer, Annette K Brenner, Kristin Vetås, Håkon Reikvam and Øystein Bruserud

    Citation: BMC Pharmacology and Toxicology 2015 16:12

    Content type: Research article

    Published on:

  15. Self-medication with antibiotics may result in antimicrobial resistance and its high prevalence is of particular concern in Low to Middle Income Countries (LMIC) like Guatemala. A better understanding of self-...

    Authors: Brooke M Ramay, Paola Lambour and Alejandro Cerón

    Citation: BMC Pharmacology and Toxicology 2015 16:11

    Content type: Research article

    Published on:

  16. In vitro and animal experiments have shown that the transport and signaling of β2-adrenergic agonists are pH-sensitive. Inhaled albuterol, a hydrophilic β2-adrenergic agonist, is widely used for the treatment of ...

    Authors: Jose E Cancado, Eliana S Mendes, Johana Arana, Gabor Horvath, Maria E Monzon, Matthias Salathe and Adam Wanner

    Citation: BMC Pharmacology and Toxicology 2015 16:9

    Content type: Research article

    Published on:

  17. The patterns and determinants of saxagliptin use among patients with type 2 diabetes mellitus (T2DM) are unknown in real-world settings. We compared the characteristics of T2DM patients who were new initiators...

    Authors: M Elle Saine, Dena M Carbonari, Craig W Newcomb, Melissa S Nezamzadeh, Kevin Haynes, Jason A Roy, Serena Cardillo, Sean Hennessy, Crystal N Holick, Daina B Esposito, Arlene M Gallagher, Harshvinder Bhullar, Brian L Strom and Vincent Lo Re III

    Citation: BMC Pharmacology and Toxicology 2015 16:8

    Content type: Research article

    Published on:

  18. The Swiss label of oral fingolimod (0.5 mg once daily) requires a 6-hour first dose observation (FDO) including an ECG prior to and 6 hours after the first intake but in comparison to other countries such as A...

    Authors: Simon P Ramseier, Serge Roth and Adam Czaplinski

    Citation: BMC Pharmacology and Toxicology 2015 16:7

    Content type: Research article

    Published on:

  19. Irrational antibiotic use is common in rural areas of China, despite the growing recognition of the importance of appropriate prescribing to contain antibiotic resistance. The aim of this study was to analyze ...

    Authors: Qiang Sun, Oliver J Dyar, Lingbo Zhao, Göran Tomson, Lennart E Nilsson, Malin Grape, Yanyan Song, Ling Yan and Cecilia Stålsby Lundborg

    Citation: BMC Pharmacology and Toxicology 2015 16:6

    Content type: Research article

    Published on:

  20. Chemotherapy-induced nausea and vomiting is one of the most influential factors that affect patient quality of life; thus, preventing this adverse event could lead to better patient outcome. Standard preventiv...

    Authors: Masahiro Inoue, Manabu Shoji, Naomi Shindo, Kazunori Otsuka, Masatomo Miura and Hiroyuki Shibata

    Citation: BMC Pharmacology and Toxicology 2015 16:5

    Content type: Research article

    Published on:

  21. Efavirenz (EFV) therapeutic response and toxicity are associated with high inter-individual variability attributed to variation in its pharmacokinetics. Plasma concentrations below 1 μg/ml may result in virolo...

    Authors: Milcah Dhoro, Simbarashe Zvada, Bernard Ngara, Charles Nhachi, Gerald Kadzirange, Prosper Chonzi and Collen Masimirembwa

    Citation: BMC Pharmacology and Toxicology 2015 16:4

    Content type: Research article

    Published on:

  22. The World Health Organization (WHO) recommends artemisinin-based combination therapies (ACTs) as first-line treatment for uncomplicated malaria. Sudan revised its malaria treatment policy accordingly in 2004. ...

    Authors: Abeer Abuzeid Atta Elmannan, Khalid Abdelmutalab Elmardi, Yassir Ali Idris, Jonathan M Spector, Nahid Abdelgadir Ali and Elfatih Mohamed Malik

    Citation: BMC Pharmacology and Toxicology 2015 16:3

    Content type: Research article

    Published on:

  23. This study aimed to determine whether single nucleotide polymorphisms (SNPs) in genes involved in DNA repair or metabolism of taxanes or platinum could predict toxicity or response to first-line chemotherapy i...

    Authors: Sandrina Lambrechts, Diether Lambrechts, Evelyn Despierre, Els Van Nieuwenhuysen, Dominiek Smeets, Philip R Debruyne, Vincent Renard, Philippe Vroman, Daisy Luyten, Patrick Neven, Frédéric Amant, Karin Leunen and Ignace Vergote

    Citation: BMC Pharmacology and Toxicology 2015 16:2

    Content type: Research article

    Published on:

  24. Patients may experience nausea and vomiting when undergoing chemotherapy or surgery requiring anesthesia. Serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonists are effective antiemetics, yet may cause a...

    Authors: Andrea C Tricco, Charlene Soobiah, Wing Hui, Jesmin Antony, Vladi Struchkov, Brian Hutton, Brenda Hemmelgarn, David Moher and Sharon E Straus

    Citation: BMC Pharmacology and Toxicology 2015 16:1

    Content type: Research article

    Published on:

  25. Safety of tenofovir disoproxil fumarate/emtricitabine (TDF-FTC) has been studied more extensively among HIV-infected patients than among HIV-uninfected people. Using data from a pre-exposure trial – FEM-PrEP –...

    Authors: Justin Mandala, Kavita Nanda, Meng Wang, Irith De Baetselier, Jennifer Deese, Johan Lombaard, Fredrick Owino, Mookho Malahleha, Rachel Manongi, Douglas Taylor and Lut Van Damme

    Citation: BMC Pharmacology and Toxicology 2014 15:77

    Content type: Research article

    Published on:

  26. The prevalence of self -medication with antibiotics is quite high in developing countries as opposed to developed countries. Antibiotics are often taken erroneously for certain ailments, without having the app...

    Authors: Syed Jawad Shah, Hamna Ahmad, Rija Binte Rehan, Sidra Najeeb, Mirrah Mumtaz, Muhammad Hashim Jilani, Muhammad Sharoz Rabbani, Muhammad Zakariya Alam, Saba Farooq and M Masood Kadir

    Citation: BMC Pharmacology and Toxicology 2014 15:74

    Content type: Research article

    Published on:

  27. National Health Service (NHS) hospitals in the UK use a system of coding for patient episodes. The coding system used is the International Classification of Disease (ICD-10). There are ICD-10 codes which may b...

    Authors: Jennifer R Bellis, Jamie J Kirkham, Anthony J Nunn and Munir Pirmohamed

    Citation: BMC Pharmacology and Toxicology 2014 15:72

    Content type: Research article

    Published on:

  28. Renal toxicity is a clinical problem that affects 28 − 42% of patients undergoing treatment with cisplatin. Renal toxicity can be minimized by high volume hydration with mannitol diuresis. Recent reports have ...

    Authors: Takako Oka, Tatsuo Kimura, Tomohiro Suzumura, Naoki Yoshimoto, Toshiyuki Nakai, Norio Yamamoto, Kuniomi Matsuura, Shigeki Mitsuoka, Naruo Yoshimura, Shinzoh Kudoh and Kazuto Hirata

    Citation: BMC Pharmacology and Toxicology 2014 15:70

    Content type: Research article

    Published on:

  29. Tacrolimus is an immunosuppressive drug that is used to lower the activity of the patient’s immune system to prevent organ rejection. Unfortunately, there is limited data regarding the therapeutic equivalency ...

    Authors: Ashraf G Madian, Arun Panigrahi, Minoli A Perera and Navin Pinto

    Citation: BMC Pharmacology and Toxicology 2014 15:69

    Content type: Case report

    Published on:

  30. Polymorphisms of Arylamine N- acetyltransferase (NAT) that contribute to diverse susceptibilities of some autoimmune diseases are also linked to the metabolism of several drugs including sulfasalazine (SSZ). The ...

    Authors: Zhi-duo Hou, Zheng-yu Xiao, Yao Gong, Yu-ping Zhang and Qing Yu Zeng

    Citation: BMC Pharmacology and Toxicology 2014 15:64

    Content type: Research article

    Published on:

  31. Idiopathic pulmonary fibrosis (IPF) is a life-limiting lung disease with considerable impact on patients and carers as the disease progresses. Currently few treatments are available. We aimed to evaluate the c...

    Authors: Emma Loveman, Vicky R Copley, Jill L Colquitt, David A Scott, Andy J Clegg, Jeremy Jones, Katherine MA O’Reilly, Sally Singh, Claudia Bausewein and Athol Wells

    Citation: BMC Pharmacology and Toxicology 2014 15:63

    Content type: Research article

    Published on:

  32. Pharmacokinetic interactions between rifampicin and protease inhibitors (PIs) complicate the management of HIV-associated tuberculosis. Rifabutin is an alternative rifamycin, for patients requiring PIs. Recent...

    Authors: Suhashni Naiker, Cathy Connolly, Lubbe Wiesner, Tracey Kellerman, Tarylee Reddy, Anthony Harries, Helen McIlleron, Christian Lienhardt and Alexander Pym

    Citation: BMC Pharmacology and Toxicology 2014 15:61

    Content type: Research article

    Published on:

  33. Inhaled endotoxin induces airways’neutrophilia, in human. TNF-a being a key cytokine in the response to endotoxin, the effect of anti-TNF on the endotoxin-induced neutrophilic response was evaluated among heal...

    Authors: Olivier Michel, Phong Huy Duc Dinh, Virginie Doyen and Francis Corazza

    Citation: BMC Pharmacology and Toxicology 2014 15:60

    Content type: Research article

    Published on:

  34. Administration of intermittent high doses of vitamin D3 is increasingly used as a strategy for rapid normalization of low 25-hydroxyvitamin D (25(OH)D) blood concentrations in patients with vitamin D deficiency. ...

    Authors: Jody van den Ouweland, Hanneke Fleuren, Miranda Drabbe and Hans Vollaard

    Citation: BMC Pharmacology and Toxicology 2014 15:57

    Content type: Case report

    Published on:

  35. Despite recent development of direct acting antivirals for treatment of hepatitis C, the current standard of care may still include pegylated-interferon, which is associated with frequent and, at times, seriou...

    Authors: Davide Mangioni, Alessandro Soria, Laura Brighina, Alessandra Bandera, Carlo Ferrarese and Andrea Gori

    Citation: BMC Pharmacology and Toxicology 2014 15:56

    Content type: Case report

    Published on:

  36. Psychiatric adverse drug reactions (ADRs) are distressing for patients and have important public health implications. We identified the drugs with the most frequent spontaneous reports of depression, and fatal...

    Authors: Kyla H Thomas, Richard M Martin, John Potokar, Munir Pirmohamed and David Gunnell

    Citation: BMC Pharmacology and Toxicology 2014 15:54

    Content type: Research article

    Published on:

  37. The current healthcare climate demands pharmacoeconomic evaluations for different treatment strategies incorporating drug acquisition costs, costs incurred for hospitalisation, drug administration and preparat...

    Authors: Helmut Ostermann, Carlos Solano, Isidro Jarque, Carolina Garcia-Vidal, Xin Gao, Jon Andoni Barrueta, Marina De Salas-Cansado, Jennifer Stephens, Mei Xue, Bertram Weber and Claudie Charbonneau

    Citation: BMC Pharmacology and Toxicology 2014 15:52

    Content type: Research article

    Published on:

  38. Lithium intoxication has potentially fatal neurologic and cardiac side effects. Extracorporeal removal can therefore be lifesaving. The dialysance of lithium is high as it is a small molecule. Comparable to it...

    Authors: Julius J Schmidt, Johan Lorenzen, Christos Chatzikyrkou, Ralf Lichtinghagen and Jan T Kielstein

    Citation: BMC Pharmacology and Toxicology 2014 15:49

    Content type: Case report

    Published on:

  39. Higher versus lower doses of antiviral drugs used to treat herpes zoster infection may lead to more adverse drug events in older adults, particularly those with chronic kidney disease.

    Authors: Ngan N Lam, Jamie L Fleet, Eric McArthur, Peter G Blake and Amit X Garg

    Citation: BMC Pharmacology and Toxicology 2014 15:48

    Content type: Research article

    Published on:

  40. In an effort to control non-medical use and/or medical abuse of prescription drugs, particularly prescription opioids, electronic prescription drug monitoring programs (PDMP) have been introduced in North-Amer...

    Authors: M Mofizul Islam and Ian S McRae

    Citation: BMC Pharmacology and Toxicology 2014 15:46

    Content type: Commentary

    Published on:

  41. This study compared palonosetron and ondansetron as rescue medications for postoperative nausea and vomiting (PONV) in patients who received prophylactic ondansetron. Although guidelines recommend use of an ag...

    Authors: Keith A Candiotti, Syed Raza Ahmed, David Cox and Tong J Gan

    Citation: BMC Pharmacology and Toxicology 2014 15:45

    Content type: Research article

    Published on:

  42. Medicines to treat common colds (CC) and upper respiratory tract infections (URTI) are widely used among children, but there are only few data about treatments actually applied for these diseases. In the prese...

    Authors: Nathalie Eckel, Giselle Sarganas, Ingrid-Katharina Wolf and Hildtraud Knopf

    Citation: BMC Pharmacology and Toxicology 2014 15:44

    Content type: Research article

    Published on:

  43. Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in com...

    Authors: Simone Azevedo de Zanette, Rafael Vercelino, Gabriela Laste, Joanna Ripoll Rozisky, André Schwertner, Caroline Buzzatti Machado, Fernando Xavier, Izabel Cristina Custódio de Souza, Alicia Deitos, Iraci L S Torres and Wolnei Caumo

    Citation: BMC Pharmacology and Toxicology 2014 15:40

    Content type: Research article

    Published on:

  44. Acetaminophen administration for more than 4 days causes aminotransferase elevation in some subjects. The objective of this randomized, placebo-controlled trial is to describe the course of alanine aminotransf...

    Authors: Kennon Heard, Jody L Green, Victoria Anderson, Becki Bucher-Bartelson and Richard C Dart

    Citation: BMC Pharmacology and Toxicology 2014 15:39

    Content type: Research article

    Published on:

  45. The pharmacodynamic (PD) efficacy target of amoxicillin is 40% time above the minimal inhibition concentration (40%T > MIC). Recent studies of other antibiotics have shown that PD-efficacy targets are not alwa...

    Authors: Michiel Haeseker, Thomas Havenith, Leo Stolk, Cees Neef, Cathrien Bruggeman and Annelies Verbon

    Citation: BMC Pharmacology and Toxicology 2014 15:38

    Content type: Research article

    Published on:

  46. Analgesics are among the most commonly consumed drugs by the world populations. Within the broader context of self-medication, pain relief occupies a prominent position. Our study was to ascertain the prevalen...

    Authors: Pilar Carrasco-Garrido, Ana López de Andrés, Valentín Hernández Barrera, Isabel Jiménez-Trujillo, César Fernandez-de-las-Peñas, Domingo Palacios-Ceña, Soledad García-Gómez-Heras and Rodrigo Jiménez-García

    Citation: BMC Pharmacology and Toxicology 2014 15:36

    Content type: Research article

    Published on:

  47. Counterfeit and unapproved medicines are inherently dangerous and can cause patient injury due to ineffectiveness, chemical or biological contamination, or wrong dosage. Growth of the counterfeit medical marke...

    Authors: Dieter Pullirsch, Julie Bellemare, Andreas Hackl, Yvon-Louis Trottier, Andreas Mayrhofer, Heidemarie Schindl, Christine Taillon, Christian Gartner, Brigitte Hottowy, Gerhard Beck and Jacques Gagnon

    Citation: BMC Pharmacology and Toxicology 2014 15:34

    Content type: Research article

    Published on:

2019 Journal Metrics