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Clinical pharmacology

This section considers submissions that focus on all areas of clinical pharmacology including rational prescribing, pharmacoeconomics, pharmacovigillance, pharmacoepidemiology and clinical trials.

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  1. Remogliflozin etabonate (RE) is the prodrug of remogliflozin, a selective inhibitor of the renal sodium-dependent glucose transporter 2 (SGLT2), which could increase urine glucose excretion (UGE) and lower pla...

    Authors: Anita Kapur, Robin O’Connor-Semmes, Elizabeth K Hussey, Robert L Dobbins, Wenli Tao, Marcus Hompesch, Glenn A Smith, Joseph W Polli, Charles D James Jr, Imao Mikoshiba and Derek J Nunez

    Citation: BMC Pharmacology and Toxicology 2013 14:26

    Content type: Research article

    Published on:

  2. Rifampicin remains one of the first-line drugs used in tuberculosis therapy. This drug´s potential to induce the hepatic cytochrome P450 oxidative enzyme system increases the risk of drug-drug interactions. Th...

    Authors: Maria AP Martins, Adriano MM Reis, Mariana F Sales, Vandack Nobre, Daniel D Ribeiro, Manoel OC Rocha and Antônio LP Ribeiro

    Citation: BMC Pharmacology and Toxicology 2013 14:27

    Content type: Case report

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  3. The sodium-dependent glucose co-transporter-2 (SGLT2) is expressed in absorptive epithelia of the renal tubules. Remogliflozin etabonate (RE) is the prodrug of remogliflozin, the active entity that inhibits SG...

    Authors: Elizabeth K Hussey, Anita Kapur, Robin O’Connor-Semmes, Wenli Tao, Bryan Rafferty, Joseph W Polli, Charles D James Jr and Robert L Dobbins

    Citation: BMC Pharmacology and Toxicology 2013 14:25

    Content type: Research article

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  4. Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued ef...

    Authors: H K Ruben Thanacoody, Alasdair Gray, James W Dear, Judy Coyle, Euan A Sandilands, David J Webb, Steff Lewis, Michael Eddleston, Simon HL Thomas and D Nicholas Bateman

    Citation: BMC Pharmacology and Toxicology 2013 14:20

    Content type: Study protocol

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  5. Dosing of antibiotics in critically ill patients is challenging. It becomes even more difficult if renal or hepatic impairment ensue. Modern means of renal replacement therapy are capable of removing antibioti...

    Authors: Christian Clajus, W Nikolaus Kühn-Velten, Julius J Schmidt, Johan M Lorenzen, Daniel Pietsch, Gernot Beutel and Jan T Kielstein

    Citation: BMC Pharmacology and Toxicology 2013 14:19

    Content type: Case report

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  6. Healthcare professional’s knowledge and attitudes to adverse drug reaction (ADR) and ADR reporting play vital role to report any cases of ADR. Positive attitudes may favour ADR reporting by healthcare professi...

    Authors: Santosh KC, Pramote Tragulpiankit, Sarun Gorsanan and I Ralph Edwards

    Citation: BMC Pharmacology and Toxicology 2013 14:16

    Content type: Research article

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  7. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provi...

    Authors: Anthony Cahn, Simon Hodgson, Robert Wilson, Jonathan Robertson, Joanna Watson, Misba Beerahee, Steve C Hughes, Graeme Young, Rebecca Graves, David Hall, Sjoerd van Marle and Roberto Solari

    Citation: BMC Pharmacology and Toxicology 2013 14:14

    Content type: Research article

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  8. Previous studies have established a correlation between vancomycin troughs and nephrotoxicity. However, data are currently lacking regarding the effect of guideline-recommended weight-based dosing on nephrotox...

    Authors: Ronald G Hall II, Kathleen A Hazlewood, Sara D Brouse, Christopher A Giuliano, Krystal K Haase, Chistopher R Frei, Nicolas A Forcade, Todd Bell, Roger J Bedimo and Carlos A Alvarez

    Citation: BMC Pharmacology and Toxicology 2013 14:12

    Content type: Research article

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  9. Antipsychotic drugs are widely used for the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD), despite their limited efficacy and concerns about safety. The aim of this study was to describ...

    Authors: Maria Gustafsson, Stig Karlsson and Hugo Lövheim

    Citation: BMC Pharmacology and Toxicology 2013 14:10

    Content type: Research article

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  10. Drugs not commonly considered to be cardioactive agents may cause prolongation of the QT interval with resultant torsades de pointes and ventricular fibrillation. This form of drug toxicity often causes cardia...

    Authors: Vincenzo Lariccia, Alessandra Moraca, Marco Marini, Annamaria Assunta Nasti, Ilaria Battistoni, Salvatore Amoroso and Gian Piero Perna

    Citation: BMC Pharmacology and Toxicology 2013 14:8

    Content type: Case report

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  11. Generic medicines are those where patent protection has expired, and which may be produced by manufacturers other than the innovator company. Use of generic medicines has been increasing in recent years, prima...

    Authors: Suzanne Dunne, Bill Shannon, Colum Dunne and Walter Cullen

    Citation: BMC Pharmacology and Toxicology 2013 14:1

    Content type: Review

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  12. The new European pharmacovigilance legislation has been suggested as marking the beginning of a new chapter in drug safety, making patients an important part of pharmacovigilance. In Sweden since 2008 it has b...

    Authors: Andreas Vilhelmsson, Tommy Svensson, Anna Meeuwisse and Anders Carlsten

    Citation: BMC Pharmacology and Toxicology 2012 13:19

    Content type: Research article

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