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Drug design, discovery and delivery

Section edited by Giorgio Palù

This section considers submissions that focus on research relating to novel chemical entity design, screening and delivery.

  1. Adolescents experience higher levels of non-adherence to HIV treatment. Drug concentration in hair promises to be reliable for assessing exposure to antiretroviral (ARV) drugs. Pharmacokinetic modelling can ex...

    Authors: Bernard Ngara, Simbarashe Zvada, Tariro Dianah Chawana, Babill Stray-Pedersen, Charles Fungai Brian Nhachi and Simbarashe Rusakaniko

    Citation: BMC Pharmacology and Toxicology 2020 21:58

    Content type: Research article

    Published on:

  2. Despite the fact that histone deacetylase (HDAC) inhibitors have been tested to treat various cardiovascular diseases, the effects of selective HDAC6 inhibitor ACY1215 on infarct size during cardiac ischemia-r...

    Authors: Chao-Feng Lin, Kai-Cheng Hsu, Wei-Chun HuangFu, Tony Eight Lin, Han-Li Huang and Shiow-Lin Pan

    Citation: BMC Pharmacology and Toxicology 2020 21:21

    Content type: Research article

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  3. 5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers. However, the development of drug resistance greatl...

    Authors: Angelika Długosz-Pokorska, Marlena Pięta, Jacek Kędzia, Tomasz Janecki and Anna Janecka

    Citation: BMC Pharmacology and Toxicology 2020 21:18

    Content type: Research article

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  4. Rosuvastatin (RSV) is a poorly water-soluble drug that has an absolute oral bioavailability of only 20%. The aim of this work was to prepare a positively charged chitosan coated flexible lipid-based vesicles (...

    Authors: Tarek A. Ahmed

    Citation: BMC Pharmacology and Toxicology 2020 21:14

    Content type: Research article

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  5. Quercetin, a pigment (flavonoid) found in many plants and foods, has good effects on protecting liver function but poor solubility and bioavailability in vivo. A drug delivery system can improve the accumulati...

    Authors: Xiangyan Liu, Yang Zhang, Ling Liu, Yifeng Pan, Yu Hu, Pu Yang and Mingmei Liao

    Citation: BMC Pharmacology and Toxicology 2020 21:11

    Content type: Research article

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  6. Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of ne...

    Authors: Yu-chi Shen, Caroline Arellano-Garcia, Rosa E. Menjivar, Ethan M. Jewett, Wolfgang Dohle, Sofiia Karchugina, Jonathan Chernoff, Barry V. L. Potter and Kate F. Barald

    Citation: BMC Pharmacology and Toxicology 2019 20:67

    Content type: Research article

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  7. Cushing’s syndrome is an endocrine disorder characterized by the overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the mainstays of pharmacological treatment. Unfortunately, they...

    Authors: Megan McGrath, Alissa Hofmann and Douglas E. Raines

    Citation: BMC Pharmacology and Toxicology 2019 20:48

    Content type: Research article

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  8. Parasitic diseases are the main challenge of livestock production in the world. They are mainly controlled by the use of anthelmintic drugs. To be effective, the drugs should contain the appropriate amount of ...

    Authors: Assegid Seifu, Elias Kebede, Belachew Bacha, Achenef Melaku and Tadese Setegn

    Citation: BMC Pharmacology and Toxicology 2019 20:20

    Content type: Research article

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  9. Diabetes mellitus is a metabolic disease in which the body is unable to produce insulin or respond to insulin production, consequently leading to abnormal metabolism of carbohydrates, lipids and proteins causi...

    Authors: Ademola O. Ayeleso, Jitcy S. Joseph, Oluwafemi O. Oguntibeju and Emmanuel Mukwevho

    Citation: BMC Pharmacology and Toxicology 2018 19:84

    Content type: Research article

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  10. Quercetin (QT) as a bioactive flavonoid has a potential therapeutic activity for numerous neuronal injuries and neurodegenerative diseases. However, the low absorption rate of QT, especially through the blood-...

    Authors: Rezvan Enteshari Najafabadi, Nasrin Kazemipour, Abolghasem Esmaeili, Siamak Beheshti and Saeed Nazifi

    Citation: BMC Pharmacology and Toxicology 2018 19:59

    Content type: Research article

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  11. L-asparaginase is a potential therapeutic enzyme widely used in the chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia. However, its use has been limited by a high rate of...

    Authors: Noura El-Ahmady El-Naggar, Sahar F. Deraz, Sara M. El-Ewasy and Ghada M. Suddek

    Citation: BMC Pharmacology and Toxicology 2018 19:51

    Content type: Research article

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  12. Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1, 4-...

    Authors: Moses N. Ngemenya, Grace Ntube Abwenzoh, Hermia Nalova Ikome, Denis Zofou, Fidele Ntie-Kang and Simon M. N. Efange

    Citation: BMC Pharmacology and Toxicology 2018 19:42

    Content type: Research article

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  13. Tomatidine (TO) is a plant steroidal alkaloid that possesses an antibacterial activity against the small colony variants (SCVs) of Staphylococcus aureus. We report here the spectrum of activity of TO against othe...

    Authors: Isabelle Guay, Simon Boulanger, Charles Isabelle, Eric Brouillette, Félix Chagnon, Kamal Bouarab, Eric Marsault and François Malouin

    Citation: BMC Pharmacology and Toxicology 2018 19:7

    Content type: Research article

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  14. Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum. Ubiquitin is a highly conserved 76 amin...

    Authors: Jagrati Jain, Surendra K. Jain, Larry A. Walker and Babu L. Tekwani

    Citation: BMC Pharmacology and Toxicology 2017 18:40

    Content type: Research article

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  15. Poor drug quality is a matter of serious concern, especially in countries where drug regulation and law enforcement are constrained by limited resources. This study was carried out to investigate the cause of ...

    Authors: Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Tep Keila, Tey Sovannarith, Heng Bun Kiet, Eav Dararth, Theingi Zin, Tsuyoshi Tanimoto and Kazuko Kimura

    Citation: BMC Pharmacology and Toxicology 2017 18:31

    Content type: Research article

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  16. NF-κB is one of the key transcription factors in the inflammatory response, transactivates a series of pro-inflammatory genes and is therefore regarded as an important target for anti-inflammatory drug screening.

    Authors: Yue Li, Xiaomeng Wang, Juan Ren, Xi Lan, Jing Li, Jing Yi, Li Liu, Yan Han, Sanqi Zhang, Dongmin Li and Shemin Lu

    Citation: BMC Pharmacology and Toxicology 2017 18:5

    Content type: Technical advance

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  17. Staphylococcus epidermidis is one of the most multiple resistances to antibiotics in the recent years. Therefore, practically-prescribed antibiotics in the treatment of these strains are not effective. Plant-deri...

    Authors: Supatcharee Siriwong, Yothin Teethaisong, Kanjana Thumanu, Benjawan Dunkhunthod and Griangsak Eumkeb

    Citation: BMC Pharmacology and Toxicology 2016 17:39

    Content type: Research article

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  18. Fimasartan (FMS) is a potent angiotensin receptor blocker for the treatment of mild to moderate hypertension. This study aimed to evaluate the transfer of FMS to fetus and breast milk in rats.

    Authors: Tae Hwan Kim, Min Gi Kim, Soyoung Shin, Yong-Ha Chi, Soo-Heui Paik, Joo-Han Lee, Sun Dong Yoo, Yu Seok Youn, Jürgen B. Bulitta, Sang Hoon Joo, Seok Won Jeong, Kwon-Yeon Weon and Beom Soo Shin

    Citation: BMC Pharmacology and Toxicology 2016 17:35

    Content type: Research article

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  19. Chagas disease, which is caused by Trypanosoma cruzi, is a major health problem in Latin America, and there are currently no drugs for the effective treatment of this disease. The energy metabolism of T. cruzi is...

    Authors: Carlos Wong-Baeza, Benjamín Nogueda-Torres, Manuel Serna, Sergio Meza-Toledo, Isabel Baeza and Carlos Wong

    Citation: BMC Pharmacology and Toxicology 2015 16:10

    Content type: Research article

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  20. There is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput drug screening techniques ...

    Authors: Anthony C Nichols, Morgan Black, John Yoo, Nicole Pinto, Andrew Fernandes, Benjamin Haibe-Kains, Paul C Boutros and John W Barrett

    Citation: BMC Pharmacology and Toxicology 2014 15:66

    Content type: Research article

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  21. Significant interest has emerged in the therapeutic and interactive effects of different cannabinoids. Cannabidiol (CBD) has been shown to have anxiolytic and antipsychotic effects with high doses administered...

    Authors: Nadia Solowij, Samantha J Broyd, Hendrika H van Hell and Arno Hazekamp

    Citation: BMC Pharmacology and Toxicology 2014 15:58

    Content type: Technical advance

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  22. The “molecular tweezer” CLR01 is a broad-spectrum inhibitor of abnormal protein self-assembly, which acts by binding selectively to Lys residues. CLR01 has been tested in several in vitro and in vivo models of am...

    Authors: Aida Attar, Wai-Ting Coco Chan, Frank-Gerrit Klärner, Thomas Schrader and Gal Bitan

    Citation: BMC Pharmacology and Toxicology 2014 15:23

    Content type: Research article

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  23. Filgrastim or methionyl-granulocyte colony-stimulating factor (Met-G-CSF), is a recombinant therapeutic protein widely used to treat severe neutropenia caused by myelosuppressive drugs in patients with nonmyel...

    Authors: Davide Crobu, Gaia Spinetti, Rodolfo Schrepfer, Giancarlo Tonon, Gloria Saccani Jotti, Pierluigi Onali, Simona Dedoni, Gaetano Orsini and Andrea Di Stefano

    Citation: BMC Pharmacology and Toxicology 2014 15:7

    Content type: Research article

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  24. Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly priorit...

    Authors: Ann-Sofie Albrekt, Henrik Johansson, Anna Börje, Carl Borrebaeck and Malin Lindstedt

    Citation: BMC Pharmacology and Toxicology 2014 15:5

    Content type: Research article

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  25. Tocopheryl acetate is viscous oily fluid used in a range of preparations for skin and scalp care in Italy. Observational and in vitro data have suggested a high level of efficacy against head louse infestation. T...

    Authors: Ian F Burgess, Nazma A Burgess and Elizabeth R Brunton

    Citation: BMC Pharmacology and Toxicology 2013 14:43

    Content type: Research article

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  26. The role of G protein-coupled receptor (GPR40), which is highly expressed in pancreatic beta cells, has been studied extensively in the amelioration of beta cell dysfunction in T2D using rat and mouse islets, ...

    Authors: Nagesh Gowda, Anilkumar Dandu, Jaideep Singh, Sanghamitra Biswas, Vijaya Raghav, Mudigere N Lakshmi, Pavagada C Shilpa, Venkategowda Sunil, Ashokkumar Reddy, Manojkumar Sadasivuni, Kumaraswamy Aparna, Mahesh Kumar Verma, Yoganand Moolemath, Mammen O Anup, Marikunte V Venkataranganna, Baggavalli P Somesh…

    Citation: BMC Pharmacology and Toxicology 2013 14:28

    Content type: Research article

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  27. By definition, a generic product is considered interchangeable with the innovator brand product. Controversy exists about interchangeability, and attention is predominantly directed to contaminants. In particu...

    Authors: Urs E Gasser, Anton Fischer, Jan P Timmermans and Isabelle Arnet

    Citation: BMC Pharmacology and Toxicology 2013 14:24

    Content type: Research article

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