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Toxicology

This section considers submissions that focus on pharmaceutical, molecular and regulatory toxicology.

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  1. There are currently no serum biomarkers capable of distinguishing elevations in serum alanine aminotransferase (ALT) that portend serious liver injury potential from benign elevations such as those occurring d...

    Authors: Rohit Singhal, Alison H Harrill, Francoise Menguy-Vacheron, Zaid Jayyosi, Hadj Benzerdjeb and Paul B Watkins

    Citation: BMC Pharmacology and Toxicology 2014 15:42

    Content type: Research article

    Published on:

  2. Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to in...

    Authors: Lisa Drange Hole, Terje Hjalmar Larsen, Kjell Ove Fossan, Fredrik Limé and Jan Schjøtt

    Citation: BMC Pharmacology and Toxicology 2014 15:28

    Content type: Research article

    Published on:

  3. This study describes the development of Response Surface Pathway (RSP) design, assesses its performance and effectiveness in estimating LD50, and compares RSP with Up and Down Procedures (UDPs) and Random Walk (R...

    Authors: Sagita Dewi, Tore Aune, John A Aasen Bunæs, Adrian J Smith and Stig Larsen

    Citation: BMC Pharmacology and Toxicology 2014 15:18

    Content type: Research article

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  4. Macrophages are equipped with several receptors for the recognition of foreign particles and pathogens. Upon binding to these receptors, particles become internalized. An interaction of particles with macropha...

    Authors: Ebru Diler, Marion Schwarz, Ruth Nickels, Michael D Menger, Christoph Beisswenger, Carola Meier and Thomas Tschernig

    Citation: BMC Pharmacology and Toxicology 2014 15:16

    Content type: Research article

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  5. A convergence of technological breakthroughs in the past decade has facilitated the development of rapid screening tools for biomarkers of toxicant exposure and effect. Platforms using the whole adult organism...

    Authors: Naissan Hussainzada, John A Lewis, Christine E Baer, Danielle L Ippolito, David A Jackson and Jonathan D Stallings

    Citation: BMC Pharmacology and Toxicology 2014 15:15

    Content type: Research article

    Published on:

  6. The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to p...

    Authors: Jérôme Breton, Sébastien Massart, Peter Vandamme, Evie De Brandt, Bruno Pot and Benoît Foligné

    Citation: BMC Pharmacology and Toxicology 2013 14:62

    Content type: Research article

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  7. Astrocytes are responsible for numerous aspects of metabolic support, nutrition, control of the ion and neurotransmitter environment in central nervous system (CNS). Failure by astrocytes to support essential ...

    Authors: Marta Sidoryk-Wegrzynowicz and Michael Aschner

    Citation: BMC Pharmacology and Toxicology 2013 14:23

    Content type: Review

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  8. Atorvastatin (a 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor) is a widely used cholesterol-lowering drug, which is recognized for its potential hepatotoxicity. This study investigated in vitro effect...

    Authors: Ali S Alfazari, Bayan Al-Dabbagh, Saeeda Almarzooqi, Alia Albawardi and Abdul-Kader Souid

    Citation: BMC Pharmacology and Toxicology 2013 14:15

    Content type: Research article

    Published on:

  9. The spatial organization of the genome is being evaluated as a novel indicator of toxicity in conjunction with drug-induced global DNA hypomethylation and concurrent chromatin reorganization. 3D quantitative D...

    Authors: Arkadiusz Gertych, Jin Ho Oh, Kolja A Wawrowsky, Daniel J Weisenberger and Jian Tajbakhsh

    Citation: BMC Pharmacology and Toxicology 2013 14:11

    Content type: Research article

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  10. Mitochondrial DNA (mtDNA) is present in multiple copies per cell and undergoes dramatic amplification during development. The impacts of mtDNA damage incurred early in development are not well understood, espe...

    Authors: Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji and Joel N Meyer

    Citation: BMC Pharmacology and Toxicology 2013 14:9

    Content type: Research article

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  11. Our previous studies suggest silkworms can be used as model animals instead of mammals in pharmacologic studies to develop novel therapeutic medicines. We examined the usefulness of the silkworm larvae Bombyx mor...

    Authors: Yoshinori Inagaki, Yasuhiko Matsumoto, Keiko Kataoka, Naoya Matsuhashi and Kazuhisa Sekimizu

    Citation: BMC Pharmacology and Toxicology 2012 13:13

    Content type: Research article

    Published on:

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