Volume 16 Supplement 1

Abstracts from the 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

Edited by Johannes-Peter Stasch, John Burnett, Harald Schmidt, Michaela Kuhn and Franz Hofmann

Publication of this supplement has been fully funded by FEBGLA e.V. Johannes-Peter Stasch is an employee of Bayer Pharma AG, Wuppertal, Germany. He holds many patents on sGC stimulators and sGC activators. John C Burnett Jr is the chairman of the advisory board for Nile Therapeutics and is a Co-Founder and the Chief Scientific Officer for Zumbro Discovery. Mayo Clinic has licensed CD-NP to Nile Therapeutics and MANP to Zumbro Discovery. The other Supplement Editors declare that they have no competing interests.

7th International Conference on cGMP Generators, Effectors and Therapeutic Implications. Go to conference site.

Trier, Germany19-21 June 2015

Concatenated PDF V16 S1

Page 2 of 3

The role of a parasite-specific D-site in activation of Plasmodium falciparum cGMP-dependent protein kinase

Authors: Eugen Franz, Jeong Joo Kim, Olga Schneider, Daniela Bertinetti, Choel Kim and Friedrich W Herberg

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A51

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Modulation of cGMP/cAMP crosstalk on the level of PDE3 in animals lacking NO-sensitive guanylyl cyclase

Authors: Andreas Friebe, Sarah Dünnes, Viacheslav Nikolaev, Barbara Lies and Dieter Groneberg

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A52

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Erythrocytes do not produce biologically active NO

Authors: Stepan Gambaryan, Igor Mindukshev, Natalia Rukoyatkina, Iraida Sharina, Emil Martin and Ulrich Walter

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A53

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Concomitant administration of sGC stimulators with common classes of anti-hypertensive agents results in increased efficacy in spontaneously hypertensive rats

Authors: Peter Germano, Jenny Tobin, Robert Jefferson, Courtney Shea, Adaline Smith, G-Yoon Jamie Im, James Sheppeck II, James Wakefield, Kristie Sykes, Maria Ribadeneira, Samuel Rivers and Jaime Masferrer

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A54

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
NO-dependent cGMP signalling in neurons and astrocytes

Authors: Jan Giesen, Ernst-Martin Füchtbauer, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A55

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Cell-specific modulation of gastrointestinal NO-induced relaxation by phosphodiesterases

Authors: Dieter Groneberg, Annemarie Aue, Barbara Lies and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A56

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
The sGC stimulator BAY 41-8543 in a rat model of hypertension-induced heart failure

Authors: N Haase, N Wilck, L Marko, A Balogh, A Heuser, D Brockschnieder, A Kretschmer, J P Stasch, N Müller and R Dechend

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A57

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
The sGC-stimulator Riociguat for the treatment of Raynaud's phenomenon: A single-dose, double-blind, randomized, placebo-controlled cross-over study (DIGIT)

Authors: Michael Huntgeburth, Johannes Kießling, Gerrit Weimann, Verena Kiepsel, Soundos Saleh, Nicolas Hunzelmann and Stephan Rosenkranz

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A58

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Discovery of IWP-051, a Novel Orally Bioavailable Soluble Guanylate Cyclase Stimulator with Sustained and Dose-Dependent Hemodynamic Effects

Authors: Takashi Nakai, Nicholas R Perl, Rajesh R Iyengar, Ara Mermerian, G-Yoon J Im, Thomas W-H Lee, Glen R Rennie, James Jia, Paul A Renhowe, Timothy C Barden, James E Sheppeck II, Karthik Iyer, Joon Jung, G Todd Milne, Chrissie Segal, Kimberly Long…

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A59

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Cyclic GMP Dependent Protein Kinase (PKG) as a mediator of EGFR-Induced Apoptosis in Breast Cancer

Authors: Nicole M Jackson and Brian P Ceresa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A60

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
CNP attenuates renal toxicity induced by cisplatin in murine kidney

Authors: Toru Kimura, Takashi Nojiri, Hiroshi Hosoda, Mikiya Miyazato and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A61

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
The NO-cGMP pathway participates in vascular adaptation to oxidative stress in Nrf2 KO mice

Authors: Ralf Erkens, Christian M Kramer, Christina Panknin, Lisann Krause, Mathias Weidenbach, Thomas Krenz, Evanthia Mergia, Malte Kelm and Miriam M Cortese-Krott

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A62

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Correlation of vascular smooth muscle cell phenotype and cGMP signalling

Authors: Moritz Lehners, Hyazinth Dobrowinski, Michael Krämer, Daniel Stehle, Martin Thunemann and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A63

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Rational design of a PKA-based sensor for cGMP

Authors: Robin Lorenz, Daniel He, Choel Kim, Chinten J Lim and Friedrich W Herberg

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A64

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Nitrite is a cGMP generator in isolated platelets

Authors: Alessandra Borgognone, Thomas Loka, Myriam Chimen, Ed Rainger, Martin Feelisch, Steve P Watson, Michael P Frenneaux and Melanie Madhani

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A65

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts

Authors: Silja Meier, Kjetil Wessel Andressen, Jan Magnus Aronsen, Ivar Sjaastad, Tor Skomedal, Jan-Bjørn Osnes, Eirik Qvigstad, Finn Olav Levy and Lise Román Moltzau

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A66

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Contribution of the NO-GC isoforms to airway responsiveness

Authors: Evanthia Mergia, Stefanie Köhler-Bachmann, Michelle Puschkarow and Doris Koesling

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A67

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Comparative analysis of established and new biosensors for cyclic nucleotides

Authors: Markus Milde, Martin Thunemann, Hariharan Subramanian, Katrin Ganzenberg, José Aparicio, Gülce Gülcüler, Viacheslav O Nikolaev and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A68

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Differential role of NO-sensitive guanylyl cyclase isoforms NO-GC1 and NO-GC2 in auditory function in adult mice

Authors: Dorit Möhrle, Nicole Eichert, Steffen Wolter, Evanthia Mergia, Doris Koesling, Andreas Friebe, Marlies Knipper and Lukas Rüttiger

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A69

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Identification and characterization of small molecular NPR-B receptor antagonists

Authors: Henriette Andresen, Lise Román Moltzau, Steffen Fagerheim, David Gloriam, Trond Bach and Finn Olav Levy

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A70

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Natriuretic peptides regulate sympathetic nervous activity independent of mineralocorticoid receptor

Authors: Hitoshi Nakagawa, Yasuki Nakada and Yoshihiko Saito

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A71

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
The world's first clinical randomized trial of atrial natriuretic peptide for preventing cancer recurrence following lung cancer surgery

Authors: Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Toru Kimura, Meinoshin Okumura and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A72

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
NMR study of a soluble Guanylate Cyclase (sGC) human homologue: the H-NOX domain from Nostoc sp.

Authors: Aikaterini Argyriou, Marina Bantzi, Athanassios Giannis, Andreas Papapetropoulos and Georgios A Spyroulias

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A73

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Functions of NO-GC1 and NO-GC2 in pain processing

Authors: Jonas Petersen, Evanthia Mergia, Oliver Drees, Ruirui Lu, Catherine Real, Andreas Friebe, Doris Koesling and Achim Schmidtko

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A74

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation

Authors: Oleksandra Prysyazhna, Joseph R Burgoyne and Philip Eaton

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A75

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Asymmetric properties of rod cGMP Phosphodiesterase 6 (PDE6): structural and functional analysis

Authors: Bilal M Qureshi, Elmar Behrmann, Johannes Schöneberg, Justus Loerke, Jörg Bürger, Thorsten Mielke, Jan Giesebrecht, Frank Noé, Klaus Peter Hofmann, Christian M T Spahn and Martin Heck

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A76

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Riociguat and cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats

Authors: Yvonne Reinke, Stefan Gross, Lars G Eckerle, Isabel Hertrich, Mathias Busch, Raila Busch, Alexander Riad, Bernhard H Rauch, Johannes-Peter Stasch, Marcus Dörr and Stephan B Felix

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A77

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
C-type natriuretic peptide prevents angiotensin II-induced cardiac remodelling and dysfunction

Authors: Konstanze Roloff, Franziska Werner, Marco Abeßer, Katharina Völker, Hideo A Baba, Kai Schuh and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A78

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Riociguat for pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD): A subgroup analysis from the PATENT studies

Authors: Rosenkranz Stephan, Hossein-Ardeschir Ghofrani, Maurice Beghetti, Dunbar Ivy, Arno Fritsch, Gerrit Weimann, Soundos Saleh, Christian Apitz and Reiner Frey

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A79

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension

Authors: Olena Rudyk, Oleksandra Prysyazhna, Lan Zhao and Philip Eaton

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A80

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Age, noise and cGMP: Pharmacological activation of soluble guanylyl cyclase (sGC) interacts with the progression of age related and noise induced hearing loss

Authors: Lukas Rüttiger, Ksenia Varakina, Dorit Möhrle, Dan Bing, Peter Sandner and Marlies Knipper

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A81

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Bioavailability, pharmacokinetics and safety of riociguat given as an oral suspension or crushed tablet with and without food

Authors: Soundos Saleh, Reiner Frey, Corina Becker, Sigrun Unger, Georg Wensing and Wolfgang Mück

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A82

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Effects of obesity on sGCβ₁ mediated signaling in white adipose tissue

Authors: Abhishek Sanyal, Linda Sarah Hoffmann, Jennifer Etzrodt and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A83

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Differentiation between first and second messenger effects of cGMP

Authors: Erich Schneider, Sabine Wolter, Fanni Dittmar, Gonzalo Fernández and Roland Seifert

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A84

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
cIMP: Synthesis, effector activation, inactivation and occurrence in biological systems

Authors: Roland Seifert, Christina Hartwig, Sabine Wolter, Erich Schneider, Heike Bähre and Volkhard Kaever

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A85

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model

Authors: Courtney Shea, Sheila Ranganath, Guang Liu, Derek Wachtel, Peter Germano, Jenny Tobin, Ping Zhang, Samuel Rivers, G-Yoon Jamie Im, James Sheppeck II and Jaime Masferrer

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A86

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Snake venom natriuretic peptides: Potential molecular probes

Authors: Sindhuja Sridharan and R Manjunatha Kini

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A87

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
The effect of natriuretic peptides and bradykinin on development of brain oedema after ischemic stroke

Authors: Marina Dobrivojević, Katarina Špiranec, Dunja Gorup, Igor Erjavec, Srećko Gajović and Aleksandra Sinđić

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A88

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Natriuretic peptides, via GC-A/cGMP, moderate hypoxia-induced VEGF release from astrocytes and thereby pathological neovascularization in the retina

Authors: Katarina Spiranec, Sabrina Hupp, Birgit Gaßner, Aleksandra Sindic and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A89

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats

Authors: P Stamm, A Jabs, M Oelze, Y Mikhed, S Kröller-Schön, P Welschof, T Jansen, M Hausding, M Kopp, S Steven, E Schulz, J-P Stasch, T Münzel and A Daiber

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A90

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Direct visualization of cGMP microdomains in adult cardiomyocytes

Authors: Hariharan Subramanian, Alexander Froese, Daniela Hübscher, Konrad R Götz and Viacheslav O Nikolaev

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A91

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Role of atrial natriuretic peptide (ANP) in the regulation of insulin secretion and vitality of pancreatic ß cells

Authors: Sabine Tauscher, Hitoshi Nakagawa, Katharina Völker, Birgit Gaßner, Saskia Pröhl and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A92

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Influence of smoking on vascular reactivity to cGMP generators in human internal thoracic arteries

Authors: Masashi Tawa, Takeshi Kinoshita, Tohru Asai, Tomoaki Suzuki, Takeshi Imamura and Tomio Okamura

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A93

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Linaclotide-induced electrolyte secretion in human and rat colon: Ussing chamber studies

Authors: Boris Tchernychev, Gerhard Hannig, David Arthur, Pei Ge, Jenny Tobin and Inmaculada Silos-Santiago

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A94

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Identification of new inhibitors of soluble guanylyl cyclase activity

Authors: Jagamya Vijayraghavan and Focco van den Akker

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A95

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Cardiac soluble guanylate cyclase protects against the cardiac dysfunction induced by chronic doxorubicin treatment in mice

Authors: Sara Vandenwijngaert, Melissa Swinnen, Hilde Gillijns, Ellen Caluwé, Robert E Tainsh, Daniel I Nathan, Kaitlin Allen, Jozef Bartunek, Peter Brouckaert, Marielle Scherrer-Crosbie, Kenneth D Bloch, Stefan P Janssens and Emmanuel S Buys

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A96

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Androgen-sensitive hypertension associated with soluble guanylate cyclase alpha1 deficiency is mediated by 20-HETE

Authors: Sara Vandenwijngaert, Ana C Dordea, Victor Garcia, Robert E Tainsh, Daniel I Nathan, Michael J Raher, Kaitlin Allen, Fan Zhang, Wolfgang S Lieb, Sarah Mikelman, Andrew Kirby, Christine Stevens, Robrecht Thoonen, Allyson Hindle, Patrick Y Sips, Rajeev Malhotra…

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A97

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Real-time imaging of cGMP signals in platelets

Authors: Lai Wen, Martin Thunemann, Kjestine Schmidt, Cor de Wit, Susanne Feil, Marcus Olbrich, Harald Langer, Meinrad Gawaz and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A98

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Differences in the renal antifibrotic signaling of serelaxin and zaprinast

Authors: Veronika Wetzl, Lothar Faerber, Franz Hofmann, Elisabeth Schinner and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A99

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF
Functional evaluation of GUCY1A3 mutations associated with myocardial infarction risk

Authors: Jana Wobst, Tan An Dang, Thorsten Kessler, Simon von Ameln, Stephanie Tennstedt, Christian Hengstenberg, Jeanette Erdmann and Heribert Schunkert

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A100

Content type: Meeting abstract Published on: 2 September 2015
- View Full Text
- View PDF

Abstracts from the 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

Important information

Annual Journal Metrics

Peer-review Terminology

Follow

BMC Pharmacology and Toxicology

Contact us