Articles

Page 12 of 21

C-type natriuretic peptide chronic administration attenuates cardiac fibrosis and inflammation in spontaneously hypertensive rats

Authors: E Santos Prentki, C Caniffi, G Bouchet, D Maglio González, J Toblli, MA Costa and C Arranz

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A104

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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C-type natriuretic peptide/guanylyl cyclase-B (GC-B) system attenuates proliferation of rhabdomyosarcoma in combination with sildenafil: A novel anticancer therapy

Authors: Masahiro Zenitani, Shuichiro Uehara, Toru Kimura, Takashi Nojiri, Koichi Miura, Hiroshi Hosoda, Mikiya Miyazato, Hiroomi Okuyama and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A103

Content type: Meeting abstract

Published on: 2 September 2015

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Interaction of cCMP with the cGK, cAK and MAPK kinases in murine tissues

Authors: Stefanie Wolfertstetter, Frank Schwede, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A101

Content type: Meeting abstract

Published on: 2 September 2015

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Functional evaluation of GUCY1A3 mutations associated with myocardial infarction risk

Authors: Jana Wobst, Tan An Dang, Thorsten Kessler, Simon von Ameln, Stephanie Tennstedt, Christian Hengstenberg, Jeanette Erdmann and Heribert Schunkert

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A100

Content type: Meeting abstract

Published on: 2 September 2015

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Differences in the renal antifibrotic signaling of serelaxin and zaprinast

Authors: Veronika Wetzl, Lothar Faerber, Franz Hofmann, Elisabeth Schinner and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A99

Content type: Meeting abstract

Published on: 2 September 2015

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Real-time imaging of cGMP signals in platelets

Authors: Lai Wen, Martin Thunemann, Kjestine Schmidt, Cor de Wit, Susanne Feil, Marcus Olbrich, Harald Langer, Meinrad Gawaz and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A98

Content type: Meeting abstract

Published on: 2 September 2015

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Androgen-sensitive hypertension associated with soluble guanylate cyclase alpha1 deficiency is mediated by 20-HETE

Authors: Sara Vandenwijngaert, Ana C Dordea, Victor Garcia, Robert E Tainsh, Daniel I Nathan, Michael J Raher, Kaitlin Allen, Fan Zhang, Wolfgang S Lieb, Sarah Mikelman, Andrew Kirby, Christine Stevens, Robrecht Thoonen, Allyson Hindle, Patrick Y Sips, Rajeev Malhotra…

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A97

Content type: Meeting abstract

Published on: 2 September 2015

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Linaclotide-induced electrolyte secretion in human and rat colon: Ussing chamber studies

Authors: Boris Tchernychev, Gerhard Hannig, David Arthur, Pei Ge, Jenny Tobin and Inmaculada Silos-Santiago

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A94

Content type: Meeting abstract

Published on: 2 September 2015

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Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats

Authors: P Stamm, A Jabs, M Oelze, Y Mikhed, S Kröller-Schön, P Welschof, T Jansen, M Hausding, M Kopp, S Steven, E Schulz, J-P Stasch, T Münzel and A Daiber

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A90

Content type: Meeting abstract

Published on: 2 September 2015

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Natriuretic peptides, via GC-A/cGMP, moderate hypoxia-induced VEGF release from astrocytes and thereby pathological neovascularization in the retina

Authors: Katarina Spiranec, Sabrina Hupp, Birgit Gaßner, Aleksandra Sindic and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A89

Content type: Meeting abstract

Published on: 2 September 2015

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IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model

Authors: Courtney Shea, Sheila Ranganath, Guang Liu, Derek Wachtel, Peter Germano, Jenny Tobin, Ping Zhang, Samuel Rivers, G-Yoon Jamie Im, James Sheppeck II and Jaime Masferrer

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A86

Content type: Meeting abstract

Published on: 2 September 2015

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cIMP: Synthesis, effector activation, inactivation and occurrence in biological systems

Authors: Roland Seifert, Christina Hartwig, Sabine Wolter, Erich Schneider, Heike Bähre and Volkhard Kaever

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A85

Content type: Meeting abstract

Published on: 2 September 2015

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Effects of obesity on sGCβ₁ mediated signaling in white adipose tissue

Authors: Abhishek Sanyal, Linda Sarah Hoffmann, Jennifer Etzrodt and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A83

Content type: Meeting abstract

Published on: 2 September 2015

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Age, noise and cGMP: Pharmacological activation of soluble guanylyl cyclase (sGC) interacts with the progression of age related and noise induced hearing loss

Authors: Lukas Rüttiger, Ksenia Varakina, Dorit Möhrle, Dan Bing, Peter Sandner and Marlies Knipper

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A81

Content type: Meeting abstract

Published on: 2 September 2015

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Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension

Authors: Olena Rudyk, Oleksandra Prysyazhna, Lan Zhao and Philip Eaton

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A80

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Riociguat for pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD): A subgroup analysis from the PATENT studies

Authors: Rosenkranz Stephan, Hossein-Ardeschir Ghofrani, Maurice Beghetti, Dunbar Ivy, Arno Fritsch, Gerrit Weimann, Soundos Saleh, Christian Apitz and Reiner Frey

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A79

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Riociguat and cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats

Authors: Yvonne Reinke, Stefan Gross, Lars G Eckerle, Isabel Hertrich, Mathias Busch, Raila Busch, Alexander Riad, Bernhard H Rauch, Johannes-Peter Stasch, Marcus Dörr and Stephan B Felix

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A77

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Asymmetric properties of rod cGMP Phosphodiesterase 6 (PDE6): structural and functional analysis

Authors: Bilal M Qureshi, Elmar Behrmann, Johannes Schöneberg, Justus Loerke, Jörg Bürger, Thorsten Mielke, Jan Giesebrecht, Frank Noé, Klaus Peter Hofmann, Christian M T Spahn and Martin Heck

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A76

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Natriuretic peptides regulate sympathetic nervous activity independent of mineralocorticoid receptor

Authors: Hitoshi Nakagawa, Yasuki Nakada and Yoshihiko Saito

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A71

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Identification and characterization of small molecular NPR-B receptor antagonists

Authors: Henriette Andresen, Lise Román Moltzau, Steffen Fagerheim, David Gloriam, Trond Bach and Finn Olav Levy

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A70

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Comparative analysis of established and new biosensors for cyclic nucleotides

Authors: Markus Milde, Martin Thunemann, Hariharan Subramanian, Katrin Ganzenberg, José Aparicio, Gülce Gülcüler, Viacheslav O Nikolaev and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A68

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Contribution of the NO-GC isoforms to airway responsiveness

Authors: Evanthia Mergia, Stefanie Köhler-Bachmann, Michelle Puschkarow and Doris Koesling

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A67

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Correlation of vascular smooth muscle cell phenotype and cGMP signalling

Authors: Moritz Lehners, Hyazinth Dobrowinski, Michael Krämer, Daniel Stehle, Martin Thunemann and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A63

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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The NO-cGMP pathway participates in vascular adaptation to oxidative stress in Nrf2 KO mice

Authors: Ralf Erkens, Christian M Kramer, Christina Panknin, Lisann Krause, Mathias Weidenbach, Thomas Krenz, Evanthia Mergia, Malte Kelm and Miriam M Cortese-Krott

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A62

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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CNP attenuates renal toxicity induced by cisplatin in murine kidney

Authors: Toru Kimura, Takashi Nojiri, Hiroshi Hosoda, Mikiya Miyazato and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A61

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Discovery of IWP-051, a Novel Orally Bioavailable Soluble Guanylate Cyclase Stimulator with Sustained and Dose-Dependent Hemodynamic Effects

Authors: Takashi Nakai, Nicholas R Perl, Rajesh R Iyengar, Ara Mermerian, G-Yoon J Im, Thomas W-H Lee, Glen R Rennie, James Jia, Paul A Renhowe, Timothy C Barden, James E Sheppeck II, Karthik Iyer, Joon Jung, G Todd Milne, Chrissie Segal, Kimberly Long…

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A59

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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The sGC stimulator BAY 41-8543 in a rat model of hypertension-induced heart failure

Authors: N Haase, N Wilck, L Marko, A Balogh, A Heuser, D Brockschnieder, A Kretschmer, J P Stasch, N Müller and R Dechend

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A57

Content type: Meeting abstract

Published on: 2 September 2015

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NO-dependent cGMP signalling in neurons and astrocytes

Authors: Jan Giesen, Ernst-Martin Füchtbauer, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A55

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Erythrocytes do not produce biologically active NO

Authors: Stepan Gambaryan, Igor Mindukshev, Natalia Rukoyatkina, Iraida Sharina, Emil Martin and Ulrich Walter

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A53

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Cyclic GMP signaling and mitochondrial BK channels in cardioprotection against ischemia/reperfusion injury

Authors: Sandra Frankenreiter, Angelina Kniess, Peter Ruth, Thomas Krieg, Andreas Friebe and Robert Lukowski

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A50

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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A CNP-cGMP-cGKI-MAPK pathway promotes melanoma growth in vitro and in vivo in mice

Authors: Sandeep Dhayade, Susanne Feil, Anja Ulmer, Susanne Kaesler, Tobias Sinnberg, Martin Thunemann, Ulrike Naumann, Tilo Biedermann, Birgit Schittek and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A49

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Catalytically active guanylyl cyclase-B requires glycosylation and mutations that inhibit this process cause dwarfism

Authors: Deborah M Dickey, Aaron B Edmond, Thomas Chaffee and Lincoln R Potter

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A44

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Nitrosopersulfide (SSNO^-) targets soluble guanylyl cyclase and induces vasodilation in vivo

Authors: Miriam M Cortese-Krott, Gunter GC Kuhnle, Alex Dyson, Bernadette O Fernandez, Marian Grman, Mark P Barrow, George McLeod, Karol Ondrias, Péter Nagy, Mervyn Singer, Malte Kelm, Anthony R Butler and Martin Feelisch

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A42

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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C-type natriuretic peptide prevents activation of perivascular mast cells and inflammation in the postischemic microvasculature

Authors: Wen Chen, Katharina Völker, Birgit Gaßner, Franziska Werner, Anja Rabenhorst, Karin Hartmann and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A41

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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A systems biology approach to cGMP suggests a prominent role for sGC in stroke: Validation by mechanism-based activation of apo-sGC in non-steal dosing coveys neuroprotection and increased survival

Authors: Ana I Casas, Friederike Langhauser, Vu Thao-Vi Dao, Emre Guney, Pamela WM Kleikers, Manuela García López, Jörg Menche, Albert-László Barabási, Christoph Kleinschnitz and Harald HHW Schmidt

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A39

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Inhaled Nitric Oxide: an sGC-dependent IOP lowering agent

Authors: Wolfgang S Lieb, Stefan Munster, Ana C Dordea, Sara Vandenwijngaert, Robert E Tainsh, Peter Brouckaert, Warren M Zapol and Emmanuel S Buys

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A38

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Computational exploration of the binding mode of the heme-dependent activator YC-1 into the active catalytic site of soluble guanylate cyclase

Authors: Luis Agulló, Ignasi Buch, Hugo Gutiérrez de Terán, Gianni de Fabritis, David Garcia-Dorado and Jordi Villà-Freixa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A32

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Receptor guanylyl cyclase-G is a sensory protein activated by cool temperatures and predator odor 2,4,5-trimethylthiazoline

Authors: Ruey-Bing Yang

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A29

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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sGC redox regulation and asthma

Authors: Dennis J Stuehr, Arnab Ghosh, Cynthia J Koziol-White, Kewal Asosingh, Georgina Cheng, Lisa Ruple, Jennifer Rodgers, Dieter Groneberg, Andreas Friebe, Johannes-Peter Stasch, Reynold A Panettieri, Mark A Aronical and Serpil C Erzurum

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A26

Content type: Meeting abstract

Published on: 2 September 2015

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Novel roles of cardiac natriuretic peptides in renal compensatory hypertrophy

Authors: Andrea Schreiber, Janina Staffel, Daniela Valletta, Michaela Kuhn and Frank Schweda

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A22

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Ultrasensitive signal detection by a guanylyl cyclase chemoreceptor

Authors: U Benjamin Kaupp

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A20

Content type: Meeting abstract

Published on: 2 September 2015

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Targeting cyclic nucleotides in CNS drug discovery: a translational approach into cognition enhancement

Authors: Jos Prickaerts

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A18

Content type: Meeting abstract

Published on: 2 September 2015

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cGMP and cAMP pathways rearrange ARHGAP17 and ARHGEF6 protein complexes to control Rac1 in platelets

Authors: Zoltan Nagy, Kieran Wynne, Alexander von Kriegsheim, Stepan Gambaryan and Albert Smolenski

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A16

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II

Authors: James C. Campbell, Kevin Y. Li, Jeong Joo Kim, Gilbert Huang, Albert S. Reger, Shinya Matsuda, Banumathi Sankaran, Todd M. Link, Keizo Yuasa, John E. Ladbury and Choel Kim

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A15

Content type: Meeting abstract

Published on: 2 September 2015

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Roles of 8-nitro-cGMP in autophagy regulation

Authors: Hirokazu Arimoto

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A14

Content type: Meeting abstract

Published on: 2 September 2015

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Cyclic GMP/cGMP-dependent protein kinase type I signaling and cysteine-rich LIM-only protein 4 in AngII/AT₁R-induced heart hypertrophy and fibrosis

Authors: Robert Lukowski, Julia Straubinger and Peter Ruth

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A13

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Gene therapy approaches to restore retinal cGMP channel function

Authors: Martin Biel

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A9

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Soluble guanylyl cyclase regulates skeletal muscle fiber type plasticity, fatigue resistance and whole body insulin resistance

Authors: Younghye Moon, Jordan Balke, Michael Siegel, Peter Brouckaert, Emmanuel S Buys, David Marcinek and Justin Percival

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A8

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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Natriuretic peptides and cGMP in metabolic disease

Authors: Sheila Collins

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A7

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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The clinical development of sGC modulators, riociguat and vericiguat

Authors: Frank Misselwitz

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A2

Content type: Meeting abstract

Published on: 2 September 2015

This article is part of a Supplement: Volume 16 Supplement 1
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