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  1. Authors: Sara Vandenwijngaert, Melissa Swinnen, Hilde Gillijns, Ellen Caluwé, Robert E Tainsh, Daniel I Nathan, Kaitlin Allen, Jozef Bartunek, Peter Brouckaert, Marielle Scherrer-Crosbie, Kenneth D Bloch, Stefan P Janssens and Emmanuel S Buys

    Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A96

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  2. The ozone challenge model can be used to assess the efficacy of anti-inflammatory compounds in early phases of clinical drug development. PUR118, a calcium salt based formulation engineered in the iSPERSETM dry p...

    Authors: Olaf Holz, H. Biller, M. Mueller, K. Kane, M. Rosano, J. Hanrahan, D. L. Hava and J. M. Hohlfeld

    Citation: BMC Pharmacology and Toxicology 2015 16:21

    Content type: Research article

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  3. Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter th...

    Authors: Adriana C. Vidal, Viktoriya Semenova, Thomas Darrah, Avner Vengosh, Zhiqing Huang, Katherine King, Monica D. Nye, Rebecca Fry, David Skaar, Rachel Maguire, Amy Murtha, Joellen Schildkraut, Susan Murphy and Cathrine Hoyo

    Citation: BMC Pharmacology and Toxicology 2015 16:20

    Content type: Research article

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  4. Long-term sedative use is prevalent and associated with significant morbidity, including adverse events such as falls, cognitive impairment, and sedation. The development of dependence can pose significant cha...

    Authors: André S. Pollmann, Andrea L. Murphy, Joel C. Bergman and David M. Gardner

    Citation: BMC Pharmacology and Toxicology 2015 16:19

    Content type: Research article

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  5. Excessive neutrophil presence and activation is important in a number of acute and chronic inflammatory diseases. The CXCR2 chemokine receptor is important in controlling the extravasation and activation of ne...

    Authors: Bruce E. Miller, Sunil Mistry, Kevin Smart, Paul Connolly, Donald C. Carpenter, Hiran Cooray, Jackie C. Bloomer, Ruth Tal-Singer and Aili L. Lazaar

    Citation: BMC Pharmacology and Toxicology 2015 16:18

    Content type: Research article

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  6. Phthalates are excipients in drug formulations. However, concerns have been raised about the effects of particular phthalates on reproduction and development. As a result the EMA has introduced guidelines for ...

    Authors: Lisa Jamieson and William McCully

    Citation: BMC Pharmacology and Toxicology 2015 16:17

    Content type: Research article

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  7. Increased use of analgesics in the population is a cause for concern in terms of drug safety. There is a paucity of population-based studies monitoring the change in use over time of both non-prescription (OTC...

    Authors: Per-Jostein Samuelsen, Lars Slørdal, Ulla Dorte Mathisen and Anne Elise Eggen

    Citation: BMC Pharmacology and Toxicology 2015 16:16

    Content type: Research article

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    The Erratum to this article has been published in BMC Pharmacology and Toxicology 2017 18:51

  8. Recent epidemiological evidences indicate close association between inorganic arsenic exposure via drinking water and cardiovascular diseases. However, the exact mechanism of this arsenic-mediated increase in ...

    Authors: Olusegun K. Afolabi, Adedoja D. Wusu, Olabisi O. Ogunrinola, Esther O. Abam, David O. Babayemi, Oluwatosin. A. Dosumu, Okechukwu. B. Onunkwor, Elizabeth. A. Balogun, Olusegun O. Odukoya and Oladipo Ademuyiwa

    Citation: BMC Pharmacology and Toxicology 2015 16:15

    Content type: Research article

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  9. Resistance to extended-spectrum cephalosporins among Enterobacteriaceae has been reported yet they serve as the last line treatment for severe infections in Uganda and other countries. This resistance often le...

    Authors: John N Kateregga, Ronah Kantume, Collins Atuhaire, Musisi Nathan Lubowa and James G Ndukui

    Citation: BMC Pharmacology and Toxicology 2015 16:14

    Content type: Research article

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  10. Cytarabine is used in the treatment of acute myeloid leukemia (AML). Low-dose cytarabine can be combined with valproic acid and all-trans retinoic acid (ATRA) as AML-stabilizing treatment. We have investigated...

    Authors: Elisabeth Ersvaer, Annette K Brenner, Kristin Vetås, Håkon Reikvam and Øystein Bruserud

    Citation: BMC Pharmacology and Toxicology 2015 16:12

    Content type: Research article

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  11. Self-medication with antibiotics may result in antimicrobial resistance and its high prevalence is of particular concern in Low to Middle Income Countries (LMIC) like Guatemala. A better understanding of self-...

    Authors: Brooke M Ramay, Paola Lambour and Alejandro Cerón

    Citation: BMC Pharmacology and Toxicology 2015 16:11

    Content type: Research article

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  12. Chagas disease, which is caused by Trypanosoma cruzi, is a major health problem in Latin America, and there are currently no drugs for the effective treatment of this disease. The energy metabolism of T. cruzi is...

    Authors: Carlos Wong-Baeza, Benjamín Nogueda-Torres, Manuel Serna, Sergio Meza-Toledo, Isabel Baeza and Carlos Wong

    Citation: BMC Pharmacology and Toxicology 2015 16:10

    Content type: Research article

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  13. In vitro and animal experiments have shown that the transport and signaling of β2-adrenergic agonists are pH-sensitive. Inhaled albuterol, a hydrophilic β2-adrenergic agonist, is widely used for the treatment of ...

    Authors: Jose E Cancado, Eliana S Mendes, Johana Arana, Gabor Horvath, Maria E Monzon, Matthias Salathe and Adam Wanner

    Citation: BMC Pharmacology and Toxicology 2015 16:9

    Content type: Research article

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  14. The patterns and determinants of saxagliptin use among patients with type 2 diabetes mellitus (T2DM) are unknown in real-world settings. We compared the characteristics of T2DM patients who were new initiators...

    Authors: M Elle Saine, Dena M Carbonari, Craig W Newcomb, Melissa S Nezamzadeh, Kevin Haynes, Jason A Roy, Serena Cardillo, Sean Hennessy, Crystal N Holick, Daina B Esposito, Arlene M Gallagher, Harshvinder Bhullar, Brian L Strom and Vincent Lo Re III

    Citation: BMC Pharmacology and Toxicology 2015 16:8

    Content type: Research article

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  15. The Swiss label of oral fingolimod (0.5 mg once daily) requires a 6-hour first dose observation (FDO) including an ECG prior to and 6 hours after the first intake but in comparison to other countries such as A...

    Authors: Simon P Ramseier, Serge Roth and Adam Czaplinski

    Citation: BMC Pharmacology and Toxicology 2015 16:7

    Content type: Research article

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  16. Irrational antibiotic use is common in rural areas of China, despite the growing recognition of the importance of appropriate prescribing to contain antibiotic resistance. The aim of this study was to analyze ...

    Authors: Qiang Sun, Oliver J Dyar, Lingbo Zhao, Göran Tomson, Lennart E Nilsson, Malin Grape, Yanyan Song, Ling Yan and Cecilia Stålsby Lundborg

    Citation: BMC Pharmacology and Toxicology 2015 16:6

    Content type: Research article

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  17. Chemotherapy-induced nausea and vomiting is one of the most influential factors that affect patient quality of life; thus, preventing this adverse event could lead to better patient outcome. Standard preventiv...

    Authors: Masahiro Inoue, Manabu Shoji, Naomi Shindo, Kazunori Otsuka, Masatomo Miura and Hiroyuki Shibata

    Citation: BMC Pharmacology and Toxicology 2015 16:5

    Content type: Research article

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  18. Efavirenz (EFV) therapeutic response and toxicity are associated with high inter-individual variability attributed to variation in its pharmacokinetics. Plasma concentrations below 1 μg/ml may result in virolo...

    Authors: Milcah Dhoro, Simbarashe Zvada, Bernard Ngara, Charles Nhachi, Gerald Kadzirange, Prosper Chonzi and Collen Masimirembwa

    Citation: BMC Pharmacology and Toxicology 2015 16:4

    Content type: Research article

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  19. The World Health Organization (WHO) recommends artemisinin-based combination therapies (ACTs) as first-line treatment for uncomplicated malaria. Sudan revised its malaria treatment policy accordingly in 2004. ...

    Authors: Abeer Abuzeid Atta Elmannan, Khalid Abdelmutalab Elmardi, Yassir Ali Idris, Jonathan M Spector, Nahid Abdelgadir Ali and Elfatih Mohamed Malik

    Citation: BMC Pharmacology and Toxicology 2015 16:3

    Content type: Research article

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  20. This study aimed to determine whether single nucleotide polymorphisms (SNPs) in genes involved in DNA repair or metabolism of taxanes or platinum could predict toxicity or response to first-line chemotherapy i...

    Authors: Sandrina Lambrechts, Diether Lambrechts, Evelyn Despierre, Els Van Nieuwenhuysen, Dominiek Smeets, Philip R Debruyne, Vincent Renard, Philippe Vroman, Daisy Luyten, Patrick Neven, Frédéric Amant, Karin Leunen and Ignace Vergote

    Citation: BMC Pharmacology and Toxicology 2015 16:2

    Content type: Research article

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  21. Patients may experience nausea and vomiting when undergoing chemotherapy or surgery requiring anesthesia. Serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonists are effective antiemetics, yet may cause a...

    Authors: Andrea C Tricco, Charlene Soobiah, Wing Hui, Jesmin Antony, Vladi Struchkov, Brian Hutton, Brenda Hemmelgarn, David Moher and Sharon E Straus

    Citation: BMC Pharmacology and Toxicology 2015 16:1

    Content type: Research article

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  22. Safety of tenofovir disoproxil fumarate/emtricitabine (TDF-FTC) has been studied more extensively among HIV-infected patients than among HIV-uninfected people. Using data from a pre-exposure trial – FEM-PrEP –...

    Authors: Justin Mandala, Kavita Nanda, Meng Wang, Irith De Baetselier, Jennifer Deese, Johan Lombaard, Fredrick Owino, Mookho Malahleha, Rachel Manongi, Douglas Taylor and Lut Van Damme

    Citation: BMC Pharmacology and Toxicology 2014 15:77

    Content type: Research article

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  23. Advanced structure-activity relationship (SAR) modeling can be used as an alternative tool for identification of skin sensitizers and in improvement of the medical diagnosis and more effective practical measur...

    Authors: Qin Ouyang, Lirong Wang, Ying Mu and Xiang-Qun Xie

    Citation: BMC Pharmacology and Toxicology 2014 15:76

    Content type: Research article

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  24. Triflusal is a drug that inhibits platelet aggregation. In this study we investigated the dose-exposure-response relationship of a triflusal formulation by population pharmacokinetic (PK) and pharmacodynamic (...

    Authors: Sung Min Park, Joomi Lee, Sook Jin Seong, Jong Gwang Park, Mi-Ri Gwon, Mi-sun Lim, Hae Won Lee, Young-Ran Yoon, Dong Heon Yang, Kwang-Il Kwon and Seunghoon Han

    Citation: BMC Pharmacology and Toxicology 2014 15:75

    Content type: Research article

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  25. The prevalence of self -medication with antibiotics is quite high in developing countries as opposed to developed countries. Antibiotics are often taken erroneously for certain ailments, without having the app...

    Authors: Syed Jawad Shah, Hamna Ahmad, Rija Binte Rehan, Sidra Najeeb, Mirrah Mumtaz, Muhammad Hashim Jilani, Muhammad Sharoz Rabbani, Muhammad Zakariya Alam, Saba Farooq and M Masood Kadir

    Citation: BMC Pharmacology and Toxicology 2014 15:74

    Content type: Research article

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  26. We have previously shown that the thromboxane (TXA2) receptor agonist, U46619, can directly induce ventricular arrhythmias that were associated with increases in intracellular calcium in cardiomyocytes. Since ...

    Authors: Chad D Touchberry, Neerupma Silswal, Vladimir Tchikrizov, Christopher J Elmore, Shubra Srinivas, Adil S Akthar, Hannah K Swan, Lori A Wetmore and Michael J Wacker

    Citation: BMC Pharmacology and Toxicology 2014 15:73

    Content type: Research article

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  27. National Health Service (NHS) hospitals in the UK use a system of coding for patient episodes. The coding system used is the International Classification of Disease (ICD-10). There are ICD-10 codes which may b...

    Authors: Jennifer R Bellis, Jamie J Kirkham, Anthony J Nunn and Munir Pirmohamed

    Citation: BMC Pharmacology and Toxicology 2014 15:72

    Content type: Research article

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  28. Renal toxicity is a clinical problem that affects 28 − 42% of patients undergoing treatment with cisplatin. Renal toxicity can be minimized by high volume hydration with mannitol diuresis. Recent reports have ...

    Authors: Takako Oka, Tatsuo Kimura, Tomohiro Suzumura, Naoki Yoshimoto, Toshiyuki Nakai, Norio Yamamoto, Kuniomi Matsuura, Shigeki Mitsuoka, Naruo Yoshimura, Shinzoh Kudoh and Kazuto Hirata

    Citation: BMC Pharmacology and Toxicology 2014 15:70

    Content type: Research article

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  29. Tacrolimus is an immunosuppressive drug that is used to lower the activity of the patient’s immune system to prevent organ rejection. Unfortunately, there is limited data regarding the therapeutic equivalency ...

    Authors: Ashraf G Madian, Arun Panigrahi, Minoli A Perera and Navin Pinto

    Citation: BMC Pharmacology and Toxicology 2014 15:69

    Content type: Case report

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  30. The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme wi...

    Authors: Nicola Laurieri, Akane Kawamura, Isaac M Westwood, Amy Varney, Elizabeth Morris, Angela J Russell, Lesley A Stanley and Edith Sim

    Citation: BMC Pharmacology and Toxicology 2014 15:68

    Content type: Research article

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  31. Lung cancer is characterized by a high mortality rate probably attributable to early metastasis. Oxidative stress is involved in development and progression of lung cancer, through cellular and molecular mecha...

    Authors: Luca Gallelli, Daniela Falcone, Monica Scaramuzzino, Girolamo Pelaia, Bruno D’Agostino, Maria Mesuraca, Rosa Terracciano, Giuseppe Spaziano, Rosario Maselli, Michele Navarra and Rocco Savino

    Citation: BMC Pharmacology and Toxicology 2014 15:67

    Content type: Research article

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  32. There is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput drug screening techniques ...

    Authors: Anthony C Nichols, Morgan Black, John Yoo, Nicole Pinto, Andrew Fernandes, Benjamin Haibe-Kains, Paul C Boutros and John W Barrett

    Citation: BMC Pharmacology and Toxicology 2014 15:66

    Content type: Research article

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Reviewer acknowledgments

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