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Carbon monoxide (CO) intoxication is a leading cause of severe neuropsychological impairments. Peripheral nerve injury has rarely been reported. It consists usually in a demyelinating polyneuropathy or mononeu...
Indoxyl sulfate (IS), an organic anion uremic toxin, promotes the progression of renal dysfunction. Some studies have suggested that IS inhibits osteoclast differentiation and suppresses parathyroid hormone (P...
Patients with febrile neutropenia (FN) exhibit changes in extracellular fluid that may alter the plasma concentrations of beta-lactams and result in therapeutic failure or toxicity. We evaluated the pharmacoki...
Chemotherapy-induced hair loss (alopecia) (CIA) is one of the most feared side effects of chemotherapy among cancer patients. There is currently no pharmacological approach to minimize CIA, although one strate...
Studies have shown that statins have pleiotropic effects on inflammation and coagulation; which may affect the risk of developing venous thromboembolism (VTE). The objective of this study was to evaluate the a...
Psychotropic drugs are widely used among old people with dementia but few studies have described long-term treatment in this group of patients. The purpose of this study was to explore the long-term use of psy...
After the clinical impact of the A(H1N1) pdm09 virus was considered to be mild, treatment with antiviral drugs was recommended only to patients who were at risk for severe disease or who had a complicated cour...
Dipyrithione (PTS2) is widely used as a bactericide and fungicide. Here, we investigated whether PTS2 has broad-spectrum antitumor activity by studying its cytotoxicity and proapoptotic effects in four cancer ...
There is a loss of lean body mass (LBM) with increasing age. A low LBM has been associated with increased adverse effects from prescribed medications such as chemotherapy. Accurate assessment of LBM may allow ...
1,3-dimethylamylamine (DMAA) has been a component of dietary supplements and is also used within "party pills," often in conjunction with alcohol and other drugs. Ingestion of higher than recommended doses res...
Given that toxicology studies the potential adverse effects of environmental exposures on various forms of life and that clinical toxicology typically focuses on human health effects, what can and should the r...
CR8 is a second generation inhibitor of cyclin-dependent kinases derived from roscovitine. CR8 was shown to be 50–100 fold more potent than roscovitine in inducing apoptosis in different tumor cell lines. In t...
Several international forums for promoting clinical pharmacology in developing countries have been held since 1980, and several clinical pharmacology programmes targeting developing countries were instituted s...
Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebiv...
Raltegravir (Isentress®)(RALT) has demonstrated excellent efficacy in both treatment-experienced and naïve patients with HIV-1 infection, and is the first strand transfer integrase inhibitor to be approved for...
Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs under...
Paraquat is a highly toxic herbicide, which not only leads to acute organ damage, but also to pulmonary fibrosis. There are only anecdotal reports of rescue lung transplantation, as paraquat is stored and only...
After several exploratory and confirmatory clinical trials, the intralesional administration of human recombinant epidermal growth factor (hrEGF) has been approved for the treatment of advanced diabetic foot u...
Tocopheryl acetate is viscous oily fluid used in a range of preparations for skin and scalp care in Italy. Observational and in vitro data have suggested a high level of efficacy against head louse infestation. T...
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
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