Articles

Page 18 of 22

Anti-interleukin-6 therapy for treatment of high platelet counts in cGMP-dependent protein kinase I gene-targeted mice

Authors: Lin Zhang, Robert Lukowski, Florian Gaertner, Michael Lorenz, Kyle R Legate, Katrin Domes, Elisabeth Angermeier, Franz Hofmann and Steffen Massberg

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P80

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Analysis of cGMP signalling with transgenic mice expressing FRET-based cGMP sensors

Authors: Lai Wen, Martin Thunemann, Susanne Feil, Matthias Hillenbrand, Angelos Vachaviolos, Thomas Ott, Xiaoxing Han, Dai Fukumura, Rakesh K Jain, Cor de Wit, Michael Russwurm and Robert Feil

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P76

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The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Authors: Benjamin Vandendriessche, Elke Rogge, Vera Goossens, Peter Vandenabeele, Johannes-Peter Stasch, Peter Brouckaert and Anje Cauwels

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P75

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Endothelial GC-A can be a therapeutic target for metabolic syndrome

Authors: Takeshi Tokudome, Kentaro Otani, Ichiro Kishimoto, Yuanjie Mao, Kazuwa Nakao and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P73

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Receptor guanylyl cyclase B-mediated cGMP signalling controls axon bifurcation of cranial sensory ganglion neurons at the embryonic hindbrain

Authors: Gohar Ter-Avetisyan, Fritz G Rathjen and Hannes Schmidt

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P71

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Differential regulation of platelet inhibition by cGMP- and cAMP-dependent protein kinases

Authors: Hariharan Subramanian, Ulrich Walter and Stepan Gambaryan

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P69

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Cardiac cGMP/cGMP-dependent protein kinase I signalling requires cysteine-rich LIM-only protein 4 (CRP4) to oppose angiotensin II induced hypertrophy and fibrosis

Authors: Julia Straubinger, Peter Ruth and Robert Lukowski

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P68

Content type: Poster presentation Published on: 29 August 2013

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Krait natriuretic peptide (KNP): a non-classical NP

Authors: Sindhuja Sridharan and R Manjunatha Kini

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P67

Content type: Poster presentation Published on: 29 August 2013

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Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway

Authors: Marton I Siklos, Ronak P Gandhi, Rui Xiong, Isaac T Schiefer, Vladislav Litosh, Lawren VandeVrede and Gregory RJ Thatcher

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P65

Content type: Poster presentation Published on: 29 August 2013

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Function of cGMP-dependent protein kinase II in volume expansion-induced diuresis

Authors: Andrea Schramm, Elisabeth Schinner and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P63

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Fishing for elusive cCMP-degrading phosphodiesterases

Authors: Erich Schneider, Maike Kuhn, Daniel Reinecke, Sabine Wolter, Heike Burhenne, Volkhard Kaever and Roland Seifert

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P62

Content type: Poster presentation Published on: 29 August 2013

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In striatum phosphodiesterase 10A is part of a synaptic signalling complex

Authors: Corina Russwurm, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P59

Content type: Poster presentation Published on: 29 August 2013

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Potent inhibition of nitroglycerin bioactivation by diphenyleneiodonium (DIP)

Authors: Regina Neubauer, Andrea Neubauer, Gerald Wölkart, Christine Schwarzenegger, Barbara Lang, Kurt Schmidt, Michael Russwurm, Doris Koesling, Antonius CF Gorren, Astrid Schrammel and Bernd Mayer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P49

Content type: Poster presentation Published on: 29 August 2013

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Video microscopy as a tool to visualize cGMP effects on contractility and sperm transport in seminiferous tubules and the epididymal duct

Authors: Andrea Mietens, Gerrit Eichner, Sabine Tasch, Caroline Feuerstacke, Ingrid Schneider-Hüther, Dieter Müller and Ralf Middendorff

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P44

Content type: Poster presentation Published on: 29 August 2013

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Alternative splicing of α1 and β1 sGC genes is altered in aortic disease

Authors: Emil Martin, Eva Golunski and Iraida Sharina

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P42

Content type: Poster presentation Published on: 29 August 2013

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Evidence for functional coupling of cGMP/cGKI signalling and TRPC channels in endothelium but not in vascular smooth muscle

Authors: Florian Loga, Katrin Domes, Marc Freichel, Veit Flockerzi, Alexander Dietrich, Lutz Birnbaumer, Franz Hofmann and Jörg W Wegener

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P40

Content type: Poster presentation Published on: 29 August 2013

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Differential effects of PDE5 inhibitors on cardiac dysfunction in the MDX ouse model of Duchenne muscular dystrophy

Authors: Sergei D Rybalkin, Masami Shimizu, Irina G Rybalkina, Enrico Patrucco, Kenneth Bible, Elina Minami, Jennifer O'Brien, Lawrence P Wennogle, Franz Hofmann, Joseph A Beavo and Stanley C Froehner

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O38

Content type: Oral presentation Published on: 29 August 2013

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A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction

Authors: Soo Ghim Lim, S Jeson Sangaralingham, Syed Ameenuddin, Fernando L Martin, Xu Wen Ng, Ying Ying Huang, Subbu S Venkatraman, John C Burnett Jr and Horng H Chen

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P38

Content type: Poster presentation Published on: 29 August 2013

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Increases survival by apo-sGC activation via post-stroke blood brain barrier stabilisation and anti-inflammation

Authors: Friedericke Langhauser, Annegret Hauck, Kim Radermacher, Johannes-Peter Stasch, Christoph Kleinschnitz and Harald HHW Schmidt

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P36

Content type: Poster presentation Published on: 29 August 2013

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Interstitial cells of Cajal plasticity rather than regeneration restores slow-wave activity and enteric neurotransmission upon acute damage

Authors: Sabine Klein, Barbara Seidler, Anna Kettenberger, Andrei Sibaev, Robert Feil, Franz Hofmann, Jean-Marie Vanderwinden, Hans-Dieter Allescher, Michael Schemann, Martin A Storr, Roland M Schmid, Günter Schneider and Dieter Saur

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P34

Content type: Poster presentation Published on: 29 August 2013

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A novel physiological significance of natriuretic peptides in cancer metastasis

Authors: Kenji Kangawa, Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome and Meinoshin Okumura

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O34

Content type: Oral presentation Published on: 29 August 2013

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NO-H₂S interactions involve cGMP

Authors: Andreas Papapetropoulos

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O32

Content type: Oral presentation Published on: 29 August 2013

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Phosphodiesterase 5 is main regulator of brown adipocyte differentiation

Authors: Ana Kilić, Thorsten Gnad, Linda S Hoffmann and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P32

Content type: Poster presentation Published on: 29 August 2013

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Cyclic GMP-mediated intercellular communication in mammalian ovarian follicles

Authors: Laurinda A Jaffe, Jeremy R Egbert, Leia C Shuhaibar, Lai Wen, Martin Thunemann, Robert Feil, Viacheslav Nikolaev, Jerid W Robinson and Lincoln R Potter

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P31

Content type: Poster presentation Published on: 29 August 2013

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Interstitial cells of Cajal link excitatory and nitrergic inhibitory neurotransmission with slow-wave activity in the intestine

Authors: Sabine Klein, Barbara Seidler, Anna Kettenberger, Andrei Sibaev, Michael Rohn, Robert Feil, Hans-Dieter Allescher, Jean-Marie Vanderwinden, Franz Hofmann, Michael Schemann, Roland Rad, Martin A Storr, Roland M Schmid, Günter Schneider and Dieter Saur

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O30

Content type: Oral presentation Published on: 29 August 2013

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Chronic activation of heme free soluble guanylate cyclase leads to cardio-renal protection in experimental hypertension

Authors: Linda S Hoffmann, Axel Kretschmer, Bettina Lawrenz, Andreas Hucke, Berthold Hocher and Johannes-Peter Stasch

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P30

Content type: Poster presentation Published on: 29 August 2013

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GUCY2C at the intersection of obesity and colorectal cancer

Authors: Scott A Waldman, Jieru E Lin, Francheska Colon-Gonzalez, Adam Snook, Michael Valentino, Gilbert Kim, Erik Blomain and Theresa Hyslop

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O28

Content type: Oral presentation Published on: 29 August 2013

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The role of VASP in cGMP-mediated vascular smooth muscle relaxation

Authors: Staffan Hildebrand, Katrin Zimmermann, Daniela Wenzel, Bernd K Fleischmann and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P28

Content type: Poster presentation Published on: 29 August 2013

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Non-genomic thyroid hormone signaling through NO/cGMP/PKGII

Authors: Hema Kalyanaraman, Raphaela Schwappacher, Jisha Joshua, Shunhui Zhuang, Brian Scott, Wolfgang Dillmann, John Frangos and Renate B Pilz

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O26

Content type: Oral presentation Published on: 29 August 2013

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PDE3 is the major cGMP-PDE in adult mouse ventricular cardiomyocytes

Authors: Konrad R Götz and Viacheslav O Nikolaev

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P26

Content type: Poster presentation Published on: 29 August 2013

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Natriuretic peptides and fat metabolism

Authors: Sheila Collins

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O24

Content type: Oral presentation Published on: 29 August 2013

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Effects of age and gender on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat

Authors: Reiner Frey, John Lettieri, Andrea Nadel, Corina Becker and Wolfgang Mück

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P23

Content type: Poster presentation Published on: 29 August 2013

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Chronic beta-adrenergic blockade prevents volume overload-induced re-localization and oxidation of soluble guanylyl cyclase

Authors: Yuchuan Liu, Louis Dell’Italia, Victor Rizzo and Emily J Tsai

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O22

Content type: Oral presentation Published on: 29 August 2013

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Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment

Authors: Reiner Frey, Corina Becker, Sigrun Unger, Anja Schmidt, Georg Wensing and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P22

Content type: Poster presentation Published on: 29 August 2013

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Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairment

Authors: Reiner Frey, Corina Becker, Sigrun Unger, Anja Schmidt, Georg Wensing and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P21

Content type: Poster presentation Published on: 29 August 2013

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Mechanisms driving heme insertion into apo-sGC during its maturation in cells

Authors: Dennis Stuehr, Arnab Ghosh, Anindya Sarkar and Yue Dai

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O18

Content type: Oral presentation Published on: 29 August 2013

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Structures of human PKG reveal cGMP-selectived activation mechanisms

Authors: Gilbert Y Huang, Jeong J Kim, Albert S Reger, Robin Lorenz, Eui-Whan Moon, Chi Zhao, Darren E Casteel, Daniela Bertinetti, Bryan VanSchouwen, Rajeevan Selvaratnam, James W Pflugrath, Banumathi Sankaran, Giuseppe Melacini, Friedrich W Herberg and Choel Kim

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O16

Content type: Oral presentation Published on: 29 August 2013

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Soluble guanylate cyclase crystal clear: 1^stcrystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity

Authors: Franziska Seeger and Elsa D Garcin

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O14

Content type: Oral presentation Published on: 29 August 2013

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Receptor guanylyl cyclase-G is a novel thermosensor in Grueneberg ganglion neurons involved in coolness-induced ultrasonic distress calls in mice

Authors: Ying-Chi Chao, Heinz Breer, Yuh-Charn Lin, Chih-Cheng Chen, Joerg Fleischer and Ruey-Bing Yang

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P14

Content type: Poster presentation Published on: 29 August 2013

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Identification and quantitation of 2´,3´-cGMP in murine tissues

Authors: Heike Burhenne, Sarah Tschirner, Roland Seifert and Volkhard Kaever

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P12

Content type: Poster presentation Published on: 29 August 2013

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G-protein signaling modulator 1 is a modifier of sGC-dependent vascular response

Authors: George Britton, Iraida Sharina and Emil Martin

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P11

Content type: Poster presentation Published on: 29 August 2013

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Pulmonary vascular adaptation to high-altitude living

Authors: Martin Wilkins

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O9

Content type: Oral presentation Published on: 29 August 2013

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Genetic variants of ANP and cardiometabolic protection: from populations to novel therapeutics

Authors: Valentina Cannone, Paul M McKie, Angelo Baldassare Cefalu, Davide Noto, Giovanni Cavera, Michele Pagano, Michelangelo Sapienza, Timothy M Olson, Denise M Heublein, Christopher G Scott, Kent R Bailey, Maurizio Averna and John C Burnett Jr

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O7

Content type: Oral presentation Published on: 29 August 2013

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Effects of omeprazole and AlOH/MgOH on riociguat absorption

Authors: Corina Becker, Reiner Frey, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P6

Content type: Poster presentation Published on: 29 August 2013

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Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat

Authors: Corina Becker, Reiner Frey, Sigrun Unger, Dirk Thomas, Michael Reber, Gerrit Weimann, Hartmut Dietrich, Erich R Arens and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P5

Content type: Poster presentation Published on: 29 August 2013

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What have genome-wide association studies taught us about cGMP and blood pressure regulation?

Authors: Christopher Newton-Cheh

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O5

Content type: Oral presentation Published on: 29 August 2013

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Effect of nitrite treatment on endothelial nitric oxide synthase in human left ventricle biopsy

Authors: Jenna Bailey, Sayqa Arif, Jorge Mascaro, Robert S Bonser, Michael P Frenneaux and Melanie Madhani

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P3

Content type: Poster presentation Published on: 29 August 2013

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Hydroxyurea reduces leukocyte interactions with the vessel wall in a haemolytic mouse model via a possible NO/cGMP-mediated effect

Authors: Camila B Almeida, Claudio C Werneck, Cristina C Vicente, Fábio T Costa, Fernando F Costa and Nicola Conran

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P2

Content type: Poster presentation Published on: 29 August 2013

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Increased nitrosative/oxidative stress lowers myocardial protein kinase G activity in heart failure with preserved ejection fraction

Authors: Loek van Heerebeek, Nazha Hamdani, Inês Falcão-Pires, Adelino F Leite-Moreira, Mark PV Begieneman, Jean GF Bronzwaer, Jolanda van der Velden, Ger JM Stienen, Gerrit J Laarman, Aernout Somsen, Freek WA Verheugt, Hans WM Niessen and Walter J Paulus

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O2

Content type: Oral presentation Published on: 29 August 2013

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Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model

Authors: Marina Aleksinskaya, Jacques Duijs, Jennifer Veth, Bettina Husen, Dania Reiche, Daniel Jasserand, Jo De Mey, Ton Rabelink and Anton Jan van Zonneveld

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P1

Content type: Poster presentation Published on: 29 August 2013

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