Featured Article: Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

QT

A study of the of published clinical studies on pharmacokinetic and/or pharmacodynamic drug-drug interactions in humans and their electrophysiological consequences (QT interval modification) suggests tremendous variability of drug-drug interaction effects, which raises awareness of the complexity of the problem, and suggests the need for assessment of an additional risk factors and careful ECG monitoring before administration of drugs with anticipated QT prolongation.

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Featured Article: Sodium nitrate decreases agrin-induced acetylcholine receptor clustering

Skeletal

A study conducted in C2C12 skeletal muscle cells suggests that sodium nitrate decreases the frequency of agrin-induced acetylcholine receptor clustering by a mechanism that includes myogenin and acetylcholine receptor gene expression. As a consequence sodium nitrate may pose a risk for skeletal muscle development and subsequent neuromuscular synapse formation in humans.

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Featured Article: Temporal trends in the utilization of vasopressors in intensive care units: an epidemiologic study

Vasopressin

A study of the clinical characteristics and the use of vasopressors collected using automated retrieval from the institutional electronic medical record system indicates they were used in one fourth of ICU admissions and one-fifth of ICU days. Although vasopressin is the most commonly used vasopressor, the use of norepinephrine has an increasing incidence.

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Aims and scope

BMC Pharmacology and Toxicology is an open access, peer-reviewed journal that considers articles on all aspects of chemically defined therapeutic and toxic agents. The journal welcomes submissions from all fields of experimental and clinical pharmacology including clinical trials.It is journal policy to publish work deemed by peer reviewers to be a coherent and sound addition to scientific knowledge and to put less emphasis on interest levels, provided that the research constitutes a useful contribution to the field.

Editor

  • Christopher Morrey, BioMed Central

Section Editors

  • Michael Aschner, Albert Einstein College of Medicine
  • Phil Biggin, University of Oxford
  • Lucio Guido Costa, University of Washington
  • David H Farb, Boston University School of Medicine
  • Giorgio Palu, University of Padova
  • Catherine MT Sherwin, University of Utah

BMC Pharmacology

BMC Pharmacology and Toxicology assimilated the Editorial boards and history of BMC Pharmacology and BMC Clinical Pharmacology on fusion of the journals in 2012. The full archive of BMC Pharmacology is available from its own archive website, and the objectives and aspirations of the merged journal are explained in the editorial that accompanied the fusion. The full archive of BMC Clinical Pharmacology is available here.

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