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  1. Study protocol

    Zinc as an adjunct treatment for reducing case fatality due to clinical severe infection in young infants: study protocol for a randomized controlled trial

    An estimated 2.7 of the 5.9 million deaths in children under 5 years of age occur in the neonatal period. Severe infections contribute to almost a quarter of these deaths. Mortality due to severe infections in...

    Nitya Wadhwa, Sudha Basnet, Uma Chandra Mouli Natchu, Laxman P. Shrestha, Shinjini Bhatnagar, Halvor Sommerfelt, Tor A. Strand, Siddarth Ramji, K. C. Aggarwal, Harish Chellani, Anuradha Govil, Mamta Jajoo, N. B. Mathur, Meenakshi Bhatt, Anup Mohta, Imran Ansari…

    BMC Pharmacology and Toxicology 2017 18:56

    Published on: 10 July 2017

  2. Research article

    Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

    Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose...

    Shijia Liu, Peidong Chen, Yang Zhao, Guoliang Dai, Bingting Sun, Yao Wang, Anwei Ding and Wenzheng Ju

    BMC Pharmacology and Toxicology 2017 18:54

    Published on: 4 July 2017

  3. Research article

    Actions of sesquiterpene lactones isolated from Moquiniastrum polymorphum subsp. floccosum in MCF7 cell line and their potentiating action on doxorubicin

    In order to obtain better clinical results in anticancer therapies, polychemotherapy or combination therapies are used. For this, the combinations are required to increase the efficacy and reduce the adverse r...

    Mariana de Oliveira Mauro, Renata Matuo, Natan de David, Regiane Lauriano Batista Strapasson, Rodrigo Juliano Oliveira, Maria Élida Alves Stefanello, Cândida Aparecida Leite Kassuya, Maria de Fátima de Cepa Matos, Fábio José Carvalho Faria and Deiler Sampaio Costa

    BMC Pharmacology and Toxicology 2017 18:53

    Published on: 29 June 2017

  4. Research article

    Drug-related problems and medication reviews among old people with dementia

    Drug-related problems, including medication errors and adverse drug events, are common among old people. Due to, for example, greater susceptibility to side effects, people with dementia are even more at risk ...

    Bettina Pfister, Jeanette Jonsson and Maria Gustafsson

    BMC Pharmacology and Toxicology 2017 18:52

    Published on: 27 June 2017

  5. Research article

    Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China

    The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use unde...

    Huan Fang, Xiaowen Lin, Jun Zhang, Zhen Hong, Kenji Sugiyama, Takao Nozaki, Tetsuro Sameshima, Susumu Kobayashi, Hiroki Namba and Tetsuya Asakawa

    BMC Pharmacology and Toxicology 2017 18:49

    Published on: 26 June 2017

  6. Research article

    The albumin-exendin-4 recombinant protein E2HSA improves glycemic control and β-cell function in spontaneous diabetic KKAy mice

    E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2H...

    Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu and Zhufang Shen

    BMC Pharmacology and Toxicology 2017 18:48

    Published on: 19 June 2017

  7. Research article

    Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway

    The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the...

    Mariam A. Ba, Jeffrey Surina, Cherie A. Singer and Maria L. Valencik

    BMC Pharmacology and Toxicology 2017 18:47

    Published on: 17 June 2017

  8. Research article

    Profound perturbation induced by triclosan exposure in mouse gut microbiome: a less resilient microbial community with elevated antibiotic and metal resistomes

    Environmental chemical-induced perturbations of gut microbiome are associated with a series of adverse health outcomes. The effects of triclosan on human health have been controversial in recent years. The pur...

    Bei Gao, Pengcheng Tu, Xiaoming Bian, Liang Chi, Hongyu Ru and Kun Lu

    BMC Pharmacology and Toxicology 2017 18:46

    Published on: 12 June 2017

  9. Research article

    Pain sensitivity and analgesic use among 10,486 adults: the Tromsø study

    Increased pain sensitivity is a putative risk factor for chronic pain and consequently for analgesic use. Conversely, analgesic use may be a cause of increased pain sensitivity, e.g., through opioid-induced hy...

    Per-Jostein Samuelsen, Christopher Sivert Nielsen, Tom Wilsgaard, Audun Stubhaug, Kristian Svendsen and Anne Elise Eggen

    BMC Pharmacology and Toxicology 2017 18:45

    Published on: 9 June 2017

  10. Research article

    Data-driven prediction of adverse drug reactions induced by drug-drug interactions

    The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-de...

    Ruifeng Liu, Mohamed Diwan M. AbdulHameed, Kamal Kumar, Xueping Yu, Anders Wallqvist and Jaques Reifman

    BMC Pharmacology and Toxicology 2017 18:44

    Published on: 8 June 2017

  11. Case report

    Tardive akathisia related to the anti-hypertensive agent Sevikar-a case report

    Tardive akathisia (TA) is a subtype of tardive syndrome, and its etiology is still uncertain. Sevikar is an anti-hypertensive agent containing both amlodipine and olmesartan, and has never been reported to hav...

    Men-Ting Hsieh, Pao-Yen Lin, Chia-Jen Tsai, Chiung-Chih Chang and Yu Lee

    BMC Pharmacology and Toxicology 2017 18:41

    Published on: 5 June 2017

  12. Research article

    Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity

    Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional stud...

    Dina Popova, Jessica Karlsson and Stig O. P. Jacobsson

    BMC Pharmacology and Toxicology 2017 18:42

    Published on: 5 June 2017

  13. Research article

    Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads

    Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum. Ubiquitin is a highly conserved 76 amin...

    Jagrati Jain, Surendra K. Jain, Larry A. Walker and Babu L. Tekwani

    BMC Pharmacology and Toxicology 2017 18:40

    Published on: 2 June 2017

  14. Research article

    Hesperetin-5,7,3’-O-triacetate suppresses airway hyperresponsiveness in ovalbumin-sensitized and challenged mice without reversing xylazine/ketamine-induced anesthesia in normal mice

    We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma ...

    You-Lan Yang, Chi-Li Chen, Chi-Ming Chen and Wun-Chang Ko

    BMC Pharmacology and Toxicology 2017 18:39

    Published on: 30 May 2017

  15. Case report

    A case report of zinc phosphide poisoning: complicated by acute renal failure and tubulo interstitial nephritis

    Run Rat® is a rodenticide widely used against small mammals. It comprises of a minimum of 32% zinc phosphide which is highly toxic in acute exposures to humans. It may be consumed accidentally or intentionally...

    Nilukshana Yogendranathan, H. M. M. T. B. Herath, Thenuka Sivasundaram, R. Constantine and Aruna Kulatunga

    BMC Pharmacology and Toxicology 2017 18:37

    Published on: 25 May 2017

  16. Research article

    Psychotropic drug use and mortality in old people with dementia: investigating sex differences

    Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to...

    Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim and Yngve Gustafson

    BMC Pharmacology and Toxicology 2017 18:36

    Published on: 25 May 2017

  17. Research article

    Antimicrobial resistance profile of Staphylococcus aureus isolates isolated from ear discharges of patients at University of Hawassa comprehensive specialized hospital

    Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a ...

    Serawit Deyno, Alemayehu Toma, Mesfin Worku and Muluken Bekele

    BMC Pharmacology and Toxicology 2017 18:35

    Published on: 15 May 2017

  18. Research article

    The salvage therapy in lung adenocarcinoma initially harbored susceptible EGFR mutation and acquired resistance occurred to the first-line gefitinib and second-line cytotoxic chemotherapy

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung ...

    Chih-Jen Yang, Jen-Yu Hung, Ming-Ju Tsai, Kuan-Li Wu, Ta-Chih Liu, Shah-Hwa Chou, Jui-Ying Lee, Jui-Sheng Hsu, Ming-Shyan Huang and Inn-Wen Chong

    BMC Pharmacology and Toxicology 2017 18:21

    Published on: 10 May 2017

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Reviewer acknowledgments