Skip to main content

Table 1 Permeation parameters

From: Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points

 

Substance

 

Diclofenac

Ibuprofen

Ketoprofen

Paracetamol

Parameter

Control

200 μm

300 μm

Control

200 μm

300 μm

Control

200 μm

300 μm

Control

200 μm

300 μm

Jmax (μg/cm²/h)

1.72

8.75

11.55

167.78

368.69

431.52

1.03

2.36

2.99

2.58

9.97

19.42

10-6 Papp (cm/s)

0.18

0.93

1.24*

1.92

4.21

5.27*

0.12

0.28

0.35*

0.04

0.16

0.31*

Recovery (%)

0.49

3.17

3.54

6.76

11.15

17.75

0.30

0.76

0.96

0.14

0.55

1.06

  1. Mean permeation parameters following substance application to bovine skin; * = p<0.05 (microneedle versus control), n = 5–6.
Back to article page

BMC Pharmacology and Toxicology

ISSN: 2050-6511

Contact us