Volume 13 Supplement 1

18th Scientific Symposium of the Austrian Pharmacological Society (APHAR)

Open Access

The differential effect of resveratrol on the renal artery of normal and diabetic rats

  • Ljiljana C Gojković-Bukarica1Email author,
  • Vladimir I Kanjuh2,
  • Radmila B Novaković1,
  • Dragana D Protić1,
  • Jelena M Cvejić3 and
  • Milica T Atanacković3
BMC Pharmacology and Toxicology201213(Suppl 1):A48

DOI: 10.1186/2050-6511-13-S1-A48

Published: 17 September 2012


Resveratrol, a polyphenol present in red wine, is thought to be responsible for cardiovascular benefits associated with moderate wine consumption. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanisms of resveratrol-induced vasorelaxation of rat renal artery (RA) with endothelium in normal and diabetic rats.


Alloxan was used for the induction of diabetes in rats. Samples of RA were obtained from male Wistar rats and were mounted in an organ bath for recording isometric tension. The experiments followed a multiple curve design.


Resveratrol relaxed RA of normal rats more potently than RA of rats with diabetes (EC50 8 and 50 µM, respectively). L-NAME and methylene blue partly antagonized the relaxation of RA of normal animals only. A nonselective blocker of voltage-gated K+ (KV) channels, 4-aminopyridine (4-AP) partly inhibited the relaxation of RA of normal as well as of diabetic rats. However, margatoxin, a selective antagonist of KV1.x channels, completely antagonized the relaxation of RA of diabetic rats only. Glibenclamide, a highly selective blocker of ATP-sensitive K+ channels, did not block resveratrol-induced relaxation in both experimental models.


In conclusion, we have shown that resveratrol induces a strong endothelium-dependent relaxation of RA of normal rats, and that 4-AP-sensitive K+ channels are involved in this relaxation. In diabetic rats, resveratrol induced NO-independent relaxation and maragtoxin-sensitive K+ channels are involved.



This work has been supported by scientific research grants no. TP31020 from the Ministry of Science, Republic of Serbia.

Authors’ Affiliations

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade
Serbian Academy of Sciences and Arts
Department of Pharmacy, Faculty of Medicine


© Gojković-Bukarica et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.