Table 3 Consumer adverse drug reactions (N) for nervous system medications in Europe by therapeutic group and seriousness (in parentheses), 2007 to 2011
From: Adverse drug reactions reported by consumers for nervous system medications in Europe 2007 to 2011
Therapeutic group (ATC level 2) | Substance | Total (serious) |
|---|---|---|
Anaesthetics (N01) | Articaine | 1(1) |
Bupivacaine | 4(4) | |
Fentanyl | 24(24) | |
Propofol | 2(2) | |
Sevoflurane | 2(2) | |
Sufentanil | 4(4) | |
Total N01 | 37(37) | |
Analgesics (N02) | Buprenorphine | 24(24) |
Codeine | 14(14) | |
Diamorphine | 3(3) | |
Dihydroergotamine | 27(27) | |
Ergotamine | 2(2) | |
Flupirtine | 6(6) | |
Frovatriptan | 2(2) | |
Hydromorphone | 22(22) | |
Metamizole | 20(20) | |
Methylergometrine | 2(2) | |
Methysergide | 25(25) | |
Morphine | 6(6) | |
Oxycodone | 56(56) | |
Paracetamol | 42(42) | |
Phenazone | 8(8) | |
Pizotifen | 2(2) | |
Propyphenazone | 7(7) | |
Sumatriptan | 3(3) | |
Tilidine | 11(10) | |
Tramadol | 62(57) | |
Total N02 | 344(338) | |
Antiepileptic drugs (N03) | Carbamazepine | 142(142) |
Clonazepam | 13(13) | |
Gabapentin | 53(53) | |
Lamotrigine | 78(78) | |
Levetiracetam | 2(2) | |
Oxcarbazepine | 36(36) | |
Phenytoin | 6(6) | |
Phenobarbital | 4(4) | |
Pregabalin | 1510(1510) | |
Topiramate | 6(6) | |
Valproate | 17(17) | |
Zonisamide | 3(3) | |
Total N03 | 1870(1870) | |
Antiparkinson drugs (N04) | Amantadine | 9(9) |
Apomorphine | 45(45) | |
Benserazide | 1(1) | |
Bromocriptine | 26(26) | |
Cabergoline | 1(1) | |
Carbidopa | 43(43) | |
Entacapone | 39(39) | |
Levodopa | 44(44) | |
Piribedil | 1(1) | |
Pramipexole | 17(17) | |
Procyclidine | 7(7) | |
Rasagiline | 15(15) | |
Rotigotine | 1(1) | |
Ropinirole | 15(15) | |
Total N04 | 264(264) | |
Antipsychotics (N05A) | Amisulpride | 1(1) |
Aripiprazole | 19(19) | |
Bromperidol | 8(8) | |
Chlorpromazine | 7(7) | |
Chlorprothixene | 23(23) | |
Clozapine | 71(71) | |
Flupentixol | 1(1) | |
Fluspirilene | 2(2) | |
Haloperidol | 12(12) | |
Levomepromazine | 9(9) | |
Lithium | 18(18) | |
Melperone | 7(7) | |
Olanzapine | 23(23) | |
Perphenazine | 12(12) | |
Pipamperone | 3(3) | |
Quetiapine | 46(46) | |
Risperidone | 37(37) | |
Sulpiride | 7(7) | |
Thioridazine | 6(6) | |
Tiapride | 6(6) | |
Zuclopenthixol | 21(21) | |
Total N05A | 339(339) | |
Anxiolytics (N05B) | Alprazolam | 17(17) |
Bromazepam | 14(14) | |
Chlordiazepoxide | 2(2) | |
Clorazepate | 9(9) | |
Diazepam | 19(19) | |
Lorazepam | 74(74) | |
Oxazepam | 8(8) | |
Total N05B | 143(143) | |
Hypnotics and sedatives (N05C) | Butalbital | 5(5) |
Clomethiazole | 5(5) | |
Flunitrazepam | 1(1) | |
Melatonin | 4(4) | |
Zaleplon | 3(3) | |
Zolpidem | 14(14) | |
Zopiclone | 12(12) | |
Total N05C | 44(44) | |
Antidepressants (N06A) | Agomelatine | 29(29) |
Amitriptyline | 11(11) | |
Bupropion | 7(7) | |
Citalopram | 38(38) | |
Clomipramine | 5(5) | |
Duloxetine | 27(27) | |
Doxepin | 1(1) | |
Escitalopram | 25(25) | |
Fluoxetine | 14(14) | |
Imipramine | 1(1) | |
Mirtazapine | 18(18) | |
Nortriptyline | 6(6) | |
Opipramol | 28(28) | |
Paroxetine | 21(21) | |
Sertraline | 22(22) | |
Trimipramine | 7(7) | |
Venlafaxine | 217(177) | |
Total N06A | 477(437) | |
Psychostimulants (N06B) | Caffeine | 16(16) |
Methylphenidate | 61(61) | |
Total N06B | 77(77) | |
Anti-dementia drugs (N06D) | Memantine | 2(2) |
Rivastigmine | 50(50) | |
Total N06D | 52(52) | |
Parasympathomimetics (N07) | Disulfiram | 11(11) |
Methylnaltrexone | 2(2) | |
Nicotine | 91(91) | |
Varenicline | 1017(135) | |
Total N07 | 1121(239) | |
Total ATC group N | 4766(2433) |