Figure 1

Representative amperograms showing endothelial NO and ONOO ^- release stimulated with nebivolol, L-755,507, 2-MeSATP, and ATP. NO (A) and ONOO^- (B) release from HUVECs were stimulated with nebivolol, ATP, 2-MeSATP, or L-755,507 (each at 1 μM). The amperograms of the 2-MeSATP partially overlaps that of L-755,507 and are omitted. NO and ONOO^- release were measured with electrochemical nanosensors positioned 5 ± 2 μm from the surface of a single cell. Arrows indicate compound administration.