Table 1 Pharmacokinetic parameters of riociguat in plasma following a single oral dose of riociguat 1 mg
Parameter | Child–Pugh A (n = 16) | Child–Pugh B (n = 16) | Control A (n = 16) | Control B (n = 16) |
|---|---|---|---|---|
AUC, μg·h/L | 371.0 (74) | 458.9 (62) | 349.9 (67) | 300.9 (92) |
Cmax, μg/L | 42.67 (37) | 43.27 (39) | 42.67 (23) | 38.68 (30) |
AUCnorm, kg·h/L | 30.9 (75) | 36.6 (65) | 29.1 (67) | 23.9 (94) |
Cmax,norm, kg/L | 3.56 (33) | 3.45 (26) | 3.55 (20) | 3.07 (23) |
t½, h | 9.19 (53) | 13.7 (50) | 9.02 (63) | 7.54 (86) |