Table 2 Comparison of selected riociguat and M1 pharmacokinetic parameters between different participant groups (ratios and 90% confidence limits)

1.40 (1.06–1.86)

1.09 (0.82–1.44)

1.16 (0.98–1.36)

1.35 (1.14–1.59)*

1.28 (0.95–1.71)

0.97 (0.72–1.30)

1.05 (0.91–1.22)

1.20 (1.03–1.38)*

1.41 (1.08–1.84)*

1.04 (0.79–1.35)

1.21 (1.00–1.46)

1.13 (0.94–1.36)

1.00 (0.73–1.38)

1.50 (1.09–2.05)*

1.10 (0.93–1.30)

1.00 (0.85–1.19)

0.91 (0.68–1.23)

1.33 (0.99–1.79)

1.22 (1.04–1.44)*

0.92 (0.78–1.08)