Population mean |
|---|
Parameter | Estimate | s.e%b
|
|---|
CL (L h−1) | 7.14d
| -- |
V (L) | 16.6 | 35 |
Ka (h-1)
| 0.0603 | 19 |
F (if cast 10 g) | 0.63 | 19 |
F (if cast 20 g) | 0.32 | 19 |
Interpatient variability
|
Parameter
|
CV%
a
|
s.e%
c
|
CL | -- | -- |
V | 89 | 74 |
ka
| -- | -- |
F | 74 | 72 |
Residual variability
|
Error type
| |
s.e%
|
σprop (CV%)e
| 29 | 50c
|
σadd (SD in mg/L)f
| 0.062 | 22b
|
- CL, mean apparent clearance; V, mean apparent volume of distribution; ka, mean absorption rate constant; F, mean bioavailability.
-
aestimates of variability expressed as coefficient of variation (CV%).
-
bs.e = standard error of the estimates (S.E), defined as S.E/estimate and expressed as percentage.
-
cs.e = standard error of the coefficient of variations, taken as , expressed as a percentage.
-
dequated to creatinine clearance (CLcr).
-
eresidual variability in the plasma concentrations associated with the proportional error term, expressed as a coefficient of variation (CV%).
-
fresidual variability in the plasma concentrations associated with the additive error term, expressed as a standard deviation (SD).
