From: Evaluation of lung recovery after static administration of three different perfluorocarbons in pigs
Baseline (Anesthetized) | Time after perfluorocarbon administration (h) | ||||
---|---|---|---|---|---|
1 (Anesthetized) | 12 (Anesthetized) | 48 (Awake) | 96 (Awake) | ||
Number of animals (n) | |||||
Control | 4 | 4 | 4 | 4 | 4 |
PFD | 4 | 4 | 4 | 3* | 3* |
PFOC | 4 | 4 | 4 | 4 | 4 |
PFOB | 4 | 4 | 4 | 4 | 4 |
Blood pH | |||||
Control | 7.45 ± 0.04 | 7.43 ± 0.03 | 7.42 ± 0.02 | 7.37 ± 0.05 | 7.36 ± 0.02 |
PFD | 7.47 ± 0.02 | 7.45 ± 0.04 | 7.43 ± 0.03 | 7.29 ± 0.11 | 7.23 ± 0.09 |
PFOC | 7.47 ± 0.01 | 7.57 ± 0.02 | 7.45 ± 0.03 | 7.31 ± 0.07 | 7.36 ± 0.03 |
PFOB | 7.45 ± 0.01 | 7.53 ± 0.02 | 7.40 ± 0.03 | 7.32 ± 0.05 | 7.38 ± 0.04 |
pO 2 (mmHg) | |||||
Control | 126 ± 6 | 118 ± 8 | 115 ± 4 | 103 ± 2 | 103 ± 2 |
PFD | 146 ± 4 | 98 ± 7 | 90 ± 13† | 84 ± 11 | 79 ± 9 |
PFOC | 137 ± 4 | 100 ± 4 | 113 ± 8‡ | 95 ± 3 | 93 ± 5 |
PFOB | 125 ± 3 | 82 ± 5† | 95 ± 12 | 92 ± 9 | 95 ± 6 |
pCO 2 (mmHg) | |||||
Control | 43 ± 4 | 45 ± 2 | 47 ± 4 | 40 ± 3 | 38 ± 2 |
PFD | 40 ± 3 | 43 ± 7 | 43 ± 4 | 44 ± 2 | 57 ± 11† |
PFOC | 37 ± 2 | 30 ± 2† ‡ | 43 ± 4 | 43 ± 2 | 43 ± 2 |
PFOB | 40 ± 1 | 35 ± 1 | 46 ± 5 | 40 ± 2 | 43 ± 5 |