From: Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation
Compound | NMDA | GABAA | ||||
---|---|---|---|---|---|---|
% Direct effect | % Agonist effect | Drug response | % Direct effect | % Agonist effect | Drug response | |
Alcohols | Â | Â | Â | Â | Â | Â |
 1-decanol | None | 70 ± 3 | - | None | 386 ± 20 | + |
 1-undecanol | None | 101 ± 2 | 0 | None | 181 ± 13 | + |
 1-dodecanol | None | 98 ± 1 | 0 | None | 177 ± 4 | + |
Alkanes | Â | Â | Â | Â | Â | Â |
 butane | None | 7 ± 2 | - | None | 623 ± 68 | + |
 pentane | None | 94 ± 3 | 0 | None | 321 ± 10 | + |
 hexane | None | 100 ± 1 | 0 | None | 129 ± 5 | + |
Aldehydes | Â | Â | Â | Â | Â | Â |
 octanal | None | 71 ± 3 | - | 6 ± 3 | 357 ± 20 | + |
 nonanal | None | 104 ± 2 | 0 | None | 219 ± 29 | + |
 decanal | None | 97 ± 3 | 0 | None | 159 ± 5 | + |
 undecanal | None | 97 ± 8 | 0 | None | 299 ± 29 | + |
Alkenes | Â | Â | Â | Â | Â | Â |
 1-pentene | None | 69 ± 1 | - | 2 ± 3 | 453 ± 38 | + |
 1-hexene | None | 97 ± 0 | 0 | None | 132 ± 2 | + |
Alkynes | Â | Â | Â | Â | Â | Â |
 1-hexyne | None | 41 ± 6 | - | 5 ± 2 | 418 ± 21 | + |
 1-heptyne | None | 68 ± 10 | - | None | 172 ± 8 | + |
 1-octyne | None | 96 ± 2 | 0 | None | 259 ± 11 | + |
Amines | Â | Â | Â | Â | Â | Â |
 1-octadecanamine | None | 73 ± 4 | - | None | 146 ± 5 | + |
 1-eicosanamine | None | 108 ± 1 | 0 | None | 166 ± 7 | + |
Benzenes | Â | Â | Â | Â | Â | Â |
 1,3-dimethylbenzene | None | 58 ± 3 | - | None | 366 ± 21 | + |
 1,3-diethylbenzene | None | 101 ± 2 | 0 | None | 305 ± 24 | + |
Cycloalkanes | Â | Â | Â | Â | Â | Â |
 cyclopentane | None | 83 ± 2 | - | 3 ± 2 | 196 ± 11 | + |
 cyclohexane | None | 101 ± 2 | 0 | None | 421 ± 17 | + |
Ethers | Â | Â | Â | Â | Â | Â |
 dibutylether | None | 59 ± 4 | - | 14 ± 13 | 347 ± 33 | + |
 dipentylether | None | 97 ± 2 | 0 | None | 211 ± 9 | + |
 dihexylether | None | 112 ± 4 | 0 | None | 113 ± 1 | + |
Esters | Â | Â | Â | Â | Â | Â |
 ethyl heptanoate | None | 78 ± 3 | - | None | 370 ± 34 | + |
 ethyl octanoate | None | 90 ± 1 | - | None | 285 ± 18 | + |
 ethyl decanoate | None | 98 ± 1 | 0 | None | 137 ± 2 | + |
Haloalkanes | Â | Â | Â | Â | Â | Â |
 1-fluoropentane | None | 76 ± 2 | - | None | 539 ± 35 | + |
 1-fluorohexane | None | 101 ± 1 | 0 | 11 ± 4 | 207 ± 13 | + |
 1-fluoroctane | None | 98 ± 1 | 0 | None | 182 ± 18 | + |
Ketones | Â | Â | Â | Â | Â | Â |
 2-decaNone | None | 81 ± 1 | - | None | 476 ± 52 | + |
 2-undecaNone | None | 98 ± 2 | 0 | None | 230 ± 16 | + |
 2-dodecaNone | None | 97 ± 3 | 0 | None | 325 ± 30 | + |
Sulfides | Â | Â | Â | Â | Â | Â |
 1-(ethylthio)-hexane | None | 87 ± 1 | - | None | 350 ± 57 | + |
 1-(ethylthio)-octane | None | 101 ± 1 | 0 | None | 120 ± 3 | + |
Thiols | Â | Â | Â | Â | Â | Â |
 1-pentanethiol | None | 85 ± 4 | - | 22 ± 8 | 466 ± 57 | + |
 1-hexanethiol | None | 102 ± 3 | 0 | 8 ± 2 | 290 ± 41 | + |