Normal rats | |||||
---|---|---|---|---|---|
Product | Nominal dose μg/kg | Cmax ng/ml | Tmax hour | AUC ng · h/ml | t½ hour |
BK0023 | 10 | 51 | 2 | 179 | 1.5 |
30 | 64 | 2 | 377 | 2.6 | |
100 | 377 | 2 | 1582 | 2.6 | |
Neupogen ® | 10 | 14 | 1 | 65 | 1.8 |
30 | 68 | 2 | 369 | 2.4 | |
100 | 272 | 1 | 1121 | 2.2 | |
Neutropenic rats | |||||
BK0023 | 10 | 27 | 2 | 134 | 1.9 |
30 | 84 | 2 | 410 | 1.7 | |
100 | 444 | 2 | 1558 | 1.8 | |
Neupogen ® | 10 | 31 | 2 | 132 | 2.0 |
30 | 87 | 2 | 485 | 2.5 | |
100 | 309 | 2 | 1620 | 2.4 |