Parameter | Description (units) | Estimates from final model | Bootstrap results | Shrinkage (%) | |
---|---|---|---|---|---|
Estimate | % RSEa | Median (95% CI) | |||
Fixed effect | |||||
Pharmacokinetic | |||||
CL/F = θ 1 * (weight/71.65)θ4 | |||||
θ 1 | TV of CL/F (L/h) for subject whose weight = 71.65 kg | 0.200 | 2.7 | 0.1998 (0.1995 – 0.2002) | |
θ 4 | Exponent of weight proportional to CL/F | 0.845 | 17.4 | 0.840 (0.830 – 0.850) | |
V d /F = θ 2 * (weight/71.65) | |||||
θ 2 | TV of V d (L) for subject whose weight = 71.65 kg | 8.300 | 2.7 | 8.281 (8.267 – 8.295) | |
k f = θ 3 | TV of k f (h-1) | 0.341 | 15.1 | 0.345 (0.341 – 0.348) | |
Pharmacodynamic | |||||
θ 5 | TV of EC 50 (μg/mL) | 84.9 | 4.0 | 85.19 (84.98 – 85.40) | |
θ 6 | TV of γ | 19.2 | 22.4 | 20.70 (20.32 – 21.08) | |
BSV (%CV) | |||||
Pharmacokinetic | |||||
ω 1 2 | BSV for CL/F | 14.9 | 21.0 | 14.4 (14.3 – 14.5) | 0.6 |
ω 2 2 | BSV for V d | 9.5 | 57.8 | 8.6 (8.4 – 8.8) | 40.2 |
ω 3 2 | BSV for k f | 88.0 | 26.5 | 73.5 (72.8 – 74.1) | 10.5 |
Pharmacodynamic | |||||
ω 4 2 | BSV for EC 50 | 21.8 | 28.4 | 21.4 (21.2 – 21.5) | 8.3 |
ω 5 2 | BSV for γ | 0 (Fixed) | NE | - | - |
Residual error (σ2)b | |||||
Proportional error | 0.098 | 6.5 | 0.0977 (0.0973 – 0.0981) | 11.5 |