BMC Pharmacology and Toxicology

Table 5 Proposed optimal doses given CYP2B6 genotypes, weight and gender

From: CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe

Variable		Females		Males
		<58 kg	>58 kg	<58 kg	>58 kg
CYP2B6*18	CYP2B6*6	1 -4 μg/ml	1 -4 μg/ml	1 -4 μg/ml	1 -4 μg/ml
TT	GG	400	400	400	400
TT	GT	200	200	200	200
TT	TT	200	200	200	200
TC	GG	400	400	400	400
TC	GT	400	200	200	200
TC	TT	200	200	200	200
CC	GG	400	600	600	600
CC	GT	200	300	300	300
CC	TT	200	200	200	200

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ISSN: 2050-6511

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