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Table 1 Minimal inhibitory concentration (MIC) of the studied samples on the tested microbial species

From: In vitro antibacterial activities of p-toluenesulfonyl-hydrazinothiazoles and hydrazinoselenazoles against multi-drug resistant Gram-negative phenotypes

Samples

E. coli strains and MIC* (mg/L) without PAβN (and with PAβN in parenthesis)

% of PAβN Modulating effect

 

E. coli strains

 

E. aerogenes strains

K. pneumoniae

P. aeruginosa

 

ATCC87 39

AG100

AG100A

AG100A tet

AG102

ATCC 13048

EACM64

EA289

EA294

EA298

EA27

ATCC 11296

KP55

KP63

PA01

PA124

p -Toluenesulfonylhydrazinothiazoles

                 

1

i

i

i

i

i

i

i

i

i (64)

i (256)

i

i

i

i

i

i

2/16 (12.5%)

2

i

i

i

i

i

i

i

i

i (64)

i

i

i

i

i

i

i

1/16 (6.3%)

3

i (256)

i

i

i

i

i

i

i

i (64)

i (256)

i

i 256 (256)

i

i

i

i

3/16 (18.8%)

4

i

i

i

i

i

i

i

i

i (64)

i (32)

i

i

i

i

i

i

2/16 (12.5%)

5

i

i

i

i

i

i

i

i

i (64)

i

i

i

i

i

i

i

1/16 (6.3%)

6

i

i

i

i

i

i

i

i

i (64)

i

i

i 256 (256)

i

i

i

i

1/16 ( 6.3%)

7

i

i

i

i

i

i

i

i

i (64)

i (256)

i

i (256)

i (256)

i

i

i

4/16 (25.0 %)

8

256 (256)

256 (256)

256 (256)

128 (128)

256 (256)

256 (256)

256 (256)

256 (256)

256 (256)

i (256)

256 (256)

256 (256)

256 (256)

256 (256)

i

256 (256)

1/16 (6.25 %)

9

i

i

i

i

i

i

i

i

i (64)

i

i

i

i

i

i

i

1/16 (6.25%)

10

i

i

i

i

i

i

i

i

i

i

i

i

i

i

i

i

0/16 ( 0%)

11

i (256)

i

i

i

i

i

i

i

i

i

i

i (256)

i

i (256)

i

i

3/16 ( 18.75%)

Hydrazinoselenazoles

                 

12

256 (4)

256 (64)

i (4)

i (16)

i (16)

i (256)

i (16)

256 (128)

i (8)

i (8)

i (128)

i (8)

128 (4)

128 (4)

i

i (256)

15/16 (93.8%)

13

256 (16)

128 (8)

128 (4)

128 (64)

i

i

i

i

i (8)

i (8)

i

128 (64)

128 (16)

32 (8)

i

i

9/16 (56.3%)

14

256 (0.5)

i (256)

i (1)

i (2)

i (8)

i (32)

i (8)

i (32)

i (2)

i (2)

i (64)

256 (2)

64 (0.5)

128 (1)

i (256)

i (256)

16/16 ( 100%)

15

i

i

i

i

i

i

i

i

i

i

i

256 (64)

32 (32)

128 (32)

i

i (256)

3/16 (18.75 %)

16

64 (2)

256 (1)

256 (2)

64 (8)

64 (8)

16 (8)

128 (8)

256 (8)

i (2)

i (2)

256 (8)

16 (2)

16 (0.5)

32(1)

128 (8)

128 (8)

16/16 (100 %)

17

i

i

i

i (256)

i

i

i

i

i (32)

i (32)

i

i 256 (16)

i (32)

i

i

i (128)

6/16 (37.5%)

18

i

i

i (128)

i

i

i

i

i

i (16)

i (32)

i

i (32)

256 (32)

i

i

i

5/16 (25.8 %)

19

i 256 (128)

i

256 (128)

256 (128)

256 (256)

i

i

i (128)

256 (32)

256 (32)

i (128)

256 (16)

256 (32)

i (256)

i

i (256)

11/16 ( 68.8%)

Chloramphenicol

4 (1)

4 (0.5)

0.5 (0.25)

32 (4)

32 (2)

4 (1)

256 (8)

i (128)

64 (16)

64 (16)

i (128)

4 (1)

32 (4)

i (128)

128 (8)

256 (8)

16/16 (100 %)

  1. *The MIC of PAßN was 64 mg/L on AG100A and >256 mg/L for other E. coli , K. pneumoniae, P. aeruginosa and E. aerogenes strains
  2. i: sample not active up to 256 mg/L; (): sample tested in presence of PAßN at 20 mg/L final concentration; (-): not tested; In bold: significant activity
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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