Independent variable | Model A | Model B | Model C | |||
---|---|---|---|---|---|---|
OR (95 % CIs) | P value | OR (95 % CIs) | P value | OR (95 % CIs) | P value | |
Metformin duration (years) | 1.03 (0.96 to 1.10) | 0.481 | - | - | - | - |
Cumulative metformin dose (g) | - | - | 1.01 (0.98 to 1.04) | 0.531 | - | - |
T2DM duration (years) | - | - | - | - | 1.03 (0.97 to 1.10) | 0.374 |
Total daily dose of metformin (g) | 1.82 (0.87 to 3.80) | 0.111 | 1.66 (0.71to 3.85) | 0.239 | 1.82 (0.88 to 3.78) | 0.107 |
Age (years) | 1.03 (0.96 to 1.10) | 0.416 | 1.03 (0.96 to 1.10) | 0.423 | 1.03 (0.96 to 1.10) | 0.429 |
HbA1c (mmol/mol) | 0.98 (0.96 to 0.99) | 0.034 | 0.97 (0.95 to 0.99) | 0.036 | 0.98 (0.95 to 0.99) | 0.034 |
Coffee Consumption (if yes) | 1.82 (0.57 to 5.80) | 0.310 | 1.81 (0.57 to 5.74) | 0.315 | 1.86 (0.58 to 5.96) | 0.294 |
Race (if black) | 0.30 (0.10 to 0.88) | 0.029 | 0.29 (0.10 to 0.87) | 0.028 | 0.30 (0.10 to 0.89) | 0.031 |
Acetylsalicylic acid use | 2.64 (0.73 to 9.58) | 0.140 | 2.63 (0.73 to 9.51) | 0.141 | 2.61 (0.72 to 9.47) | 0.144 |
Number of metformin daily doses | 0.84 (0.33 to 2.11) | 0.705 | 0.84 (0.33 to 2.12) | 0.707 | 0.82 (0.32 to 2.06) | 0.669 |
eGFR (mL/min/1.73 m2) | 0.99 (0.98 to 1.01) | 0.703 | 0.99 (0.98 to 1.01) | 0.692 | 0.99 (0.98 to 1.01) | 0.759 |