Fig. 1

One hundred ninety drugs shared side effect profile similarities with 27 antidepressants in the study. Drugs are represented by dots and similarities between drugs are represented by edges between dots. The thickness of the edges represents the cosine correlation coefficient as determined by formula 1, which represents the degree of side effect similarity between drugs. a Different type of antidepressants formed different clusters according to their side effect profiles. The antidepressants are colored according to their type, while other drugs are colored yellow. b Anti-inflammatory drugs and immunosuppressants with side effect profile similar to antidepressants. The antidepressants are colored blue, while other drugs are colored according to their function and/or targets. Drugs that are out of the scope of this study (i.e. not immune related and have limited evidence of antidepressant-like activities) are colored yellow to simplify the background