Fig. 2

Comparison of pretreatments on nicotine reinstatement. All groups extinguished nicotine-seeking behavior when environmental cues as well as nicotine were removed. Reinstatement consisted of pretreatment followed by a nicotine priming injection 5 min prior to the session as well as reintroduction of the environmental cues associated with nicotine infusions. Nicotine was not available during reinstatement sessions. All drug based pretreatments significantly reduced reinstatement responding from reaching nicotine baseline levels (Nic Baseline). All data is presented as mean + S.E.M. comparisons are made against Nic Baseline within group, two-way ANOVA, n = 6 per group, *p < 0.05, **p < 0.01, ***p < 0.001