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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Actions of sesquiterpene lactones isolated from Moquiniastrum polymorphum subsp. floccosum in MCF7 cell line and their potentiating action on doxorubicin

Fig. 5

Effects of 1 on the Combination Index (CI) of drugs in MCF7 cell line. Compound 1 concentrations (40; 100; 200; 300 and 400 μM) were combined with the IC50 of the chemotherapeutic agents irinotecan a, tamoxifen b, cisplatin c, 5-Fluouracyl d and doxorubicin e. CI and the normalized isobolograms was calculated using the CompuSyn software, where: CI <1 synergism; CI = 1 additive effect; CI > 1 antagonistic effect

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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