Fig. 3From: Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signalingLentinan antagonized oxidative stress and inflammatory signals in liver. A. Histogram of oxidative stress indicators MDA, GSH after SA treatment or Lentinan intervention. An increased MDA and a reduced GSH in liver were found in SA treatment group, which were antagonized consistently by Lentinan intervention; B Characteristics of inflammatory signals OX40, IL-17A after SA treatment or Lentinan intervention. SA induced the upregulations of proinflammatory signals OX40, IL-17A, while was downregulated significantly after Lentinan intervention. Data were expressed as mean ± SD; n = 5. The levels of MDA, GSH, OX40, and IL-17A in liver tissues were quantified by the convertion of OD values to nanomole or picogram values of per gram liver tissue (nmol or pg/g tissue) according to the standard curve and dilution ratio. Significant difference was obtained by independent sample’s t-test followed ANOVA. *P < 0.05 indicates a significant difference compared with control; #P < 0.05 indicates a significant difference compared with SA treatment. Abbreviations: IL, Interleukin; MDA, malondialdehyde; GSH, glutathione; OX40 (CD134), Tumor necrosis factor receptor superfamily member 4Back to article page