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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm

Fig. 4

DEX protects VSMCs against H2O2-induced oxidative damage and inflammation response. A-C Western blotting was conducted to measure the protein levels of SM22α and αSMA. D-F Measurement of NQO-1, GCLC and SOD1 levels. G-I Quantification of TNF-α, IL-6 and MCP-1 levels. *p < 0.05, **p < 0.01. DEX, dexmedetomidine; BRL, BRL44408, α2AR inhibitor; SB, SB216763, GSK-3β inhibitor

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