Table 4 Effect of SAA on micronucleus formation
Group | Time of post-administration | Dose (mg/kg) | Micronucleus | MNPCE (‰) | PCE/(NCE + PCE) |
|---|---|---|---|---|---|
Control | 24 h | / | 30 | 2.50 | 0.614 ± 0.026 |
CP | 50 | 303 | 25.25** | 0.386 ± 0.014** | |
SAA | 200 | 26 | 2.17 | 0.614 ± 0.021 | |
400 | 20 | 1.67 | 0.598 ± 0.035 | ||
800 | 20 | 1.67 | 0.596 ± 0.037 | ||
Control | 48 h | / | 25 | 2.08 | 0.608 ± 0.034 |
CP | 50 | 282 | 23.50** | 0.385 ± 0.015** | |
SAA | 200 | 19 | 1.58 | 0.595 ± 0.031 | |
400 | 19 | 1.58 | 0.594 ± 0.022 | ||
800 | 21 | 1.75 | 0.605 ± 0.032 | ||
**P < 0.01 vs. Control. Abbreviations: CP, Cyclophosphamide. | |||||