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Table 2 Pharmacokinetic parameters of Voriconazole test and reference formulations in the 4 mg/kg group (n = 24)

From: Pharmacokinetics and safety of two Voriconazole formulations after intravenous infusion in two doses in healthy Chinese subjects

Parameter

Arithmetic mean ± SD (%CV)a

T

R

Cmaxb(μg/mL)

2.552 ± 0.448 (0.018)

2.615 ± 0.464 (0.018)

AUC0–tc(h*μg/mL)

11.875 ± 7.157 (0.060)

12.500 ± 7.257 (0.058)

AUC0–∞d(h*μg/mL)

12.835 ± 9.813 (0.076)

13.416 ± 9.485 (0.071)

T1/2e(h)

7.96 ± 4.89 (61.41)

7.91 ± 4.45 (56.24)

tmaxf(h)

1.33 (1.00, 1.50)

1.33 (1.00, 1.45)

  1. aAll values are represented as arithmetic mean ± standard deviation (CV, %) with [geometric mean] unless otherwise specified. *tmax is shown as median (minimum–maximum)
  2. bCmax: maximum plasma concentration
  3. cAUC0-t: area under the plasma concentration–time curve from 0 to the last measured time point
  4. dAUC0-∞: area under the plasma concentration–time curve from 0 to infinity
  5. eT1/2: terminal half-life
  6. fTmax: time to Cmax