Fig. 1

Three cycles of cisplatin treatment caused ototoxicity in C57BL/6 mice. A Hearing threshold shifts were observed in C57BL/6 mice at 8, 16 and 32 kHz. N = 10 per group. B Immunofluorescent staining (myosin VIIa) of the basilar membrane from a representative cochlear section.C. Outer hair cell counting obtained from five independent cochlear dissections at the apical, middle and basal turns. Scale bar = 20 µM. n = 5, ****P < 0.0001