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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Vanillic acid alleviates methamphetamine-induced mitochondrial toxicity in cardiac mitochondria via antioxidant activity and inhibition of MPT Pore opening: an in-vitro study

Fig. 1

Enhancement of mitochondrial succinate dehydrogenase in cardiac mitochondria by VA in presence of methamphetamine. Cardiac mitochondria were treated/cotreated with methamphetamine, methamphetamine plus various concentrations (10, 50 and 100 µM) of VA and VA (100 µM) alone for 60 min. Mitochondrial succinate dehydrogenase was evaluated by MTT assay. Results were presented as a percentage of control measured in the absence of the compounds. Each point represents the mean ± SD of five independent experiments. *** p < 0.001 versus untreated control; ## p < 0.01 versus methamphetamine group; ### p < 0.001 versus methamphetamine group (one-way ANOVA followed by Tukey’s multiple comparison tests). SDH, succinate dehydrogenase; METH, methamphetamine; VA, Vanillic acid

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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