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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Metformin alleviates adriamycin resistance of osteosarcoma by declining YY1 to inhibit MDR1 transcriptional activity

Fig. 2

Met increased sensitivity of MG-63/ADM cells to ADM and accelerated cell apoptosis. (A) MG-63/ADM cells were treated with different concentrations of Met ranging from 1mM to 10 mM and cell viability was assessed by MTT assay. (B) IC50 value was calculated MG-63/ADM cells with Met treatment. (C) ADM induced apoptosis of MG-63/ADM cells after Met induction was determined by flow cytometry. (D) The apoptosis rate was calculated. All the results were shown as mean ± SD (n = 3), which were three separate experiments performed in triplicate. *P < 0.05, ***P < 0.001

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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