Fig. 5

The effect of LBH589 combined with AM1241 on apoptosis and oxidative stress. A-D Apoptosis detection (n = 3). ^*P < 0.05, ^**P < 0.005, ^***P < 0.001. E and F The effect of LBH589 combined with AM1241 monotherapy on ROS (n = 3), ^***P < 0.001. G and H To detect the effect on apoptosis after adding ROS scavenger NAC or autophagy inhibitor 3-MA (n = 3), ^**P < 0.01, ^***P < 0.001