Table 1 Mean pharmacokinetic parameters of lidocaine and prilocaine in T (n = 38) and R formulations (n = 40)

C_max (ng/mL)

22.0 ± 10.9

22.9 ± 15.8

12.3 ± 7.0

12.2 ± 9.7

AUC_0 - t(ng.h/mL)

206.5 ± 77.1

206.9 ± 95.7

97.3 ± 43.8

95.3 ± 55.8

AUC_0-∞(ng.h/mL)

208.3 ± 77.1

208.6 ± 95.6

98.3 ± 43.6

96.2 ± 55.7

t_1/2 (h)

5.6 ± 1.2

5.5 ± 1.2

6.5 ± 2.0

6.3 ± 1.7

T_max^* (h)

8.0(3.5,12.0)

8.0(3.5,10.0)

7.5(3.0,10.0)

8.0(3.5,10.0)